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Biomedical subjects

T George

Publications and source records attributed to T George.

At least 73 records · Page 4Linked to original sources
PubMed1991

Non-Q- and Q-wave infarction after thrombolytic therapy with intravenous streptokinase for chest pain and anterior ST-segment elevation.

The clinical features of patients treated with streptokinase for chest pain and anterior ST-segment elevation who subsequently develop non-Q-wave infarction are unknown. Of the 75 consecutive patients who initially presented with chest pain and ST-segment elevation in the anterior leads (V1-V6, I, aVL) and were treated with intravenous streptokinase (time from symptoms to treatment averaged less than 3 hours), 32 (43%) developed a non-Q-wave and 43 (57%) a Q-wave myocardial infarction. Twenty seven of 32 patients (84%) from the non-Q-wave group and 39 of 43 (91%) from the Q-wave group were studied by angiography at 5.16 +/- 2.88 days after the onset of myocardial infarction. Left ventricular end-diastolic pressure was 13 +/- 6 vs 20 +/- 7 mm Hg (p less than 0.001), left ventricular ejection fraction was 60 +/- 8 vs 49 +/- 14% (p less than 0.001) and the infarct vessel patency rate was 85 vs 72% (p = 0.44) in patients with a non-Q versus a Q-wave infarction, respectively. In summary, when patients presenting with chest pain and ST-segment elevation are treated with streptokinase, a significant portion of these symptoms will evolve into a non-Q-wave infarction. Patients with a non-Q-wave infarction will have a better preserved left ventricular function than patients who develop a Q-wave infarction. This suggests the need for equal distribution of such patients in randomized trials of thrombolytic therapy for acute myocardial infarction to avoid misinterpreting data between groups.

Adult↗
PubMed1991

Determination of the absolute configuration of a novel dipeptide isostere.

(1R-[1 alpha(1R*,2R*,3S*),2 beta,5 alpha])-2-(4-Morpholinocarbonyl)- 3-phenylcyclopropane 2-(1-methyl-ethyl)-5-methylcyclohexyl ester, C25H35NO4, Mr = 413 x 56, orthorhombic, P2(1)2(1)2(1), a = 9 x 359 (2), b = 10 x 1172 (14), c = 24 x 710 (4) A, V = 2339 x 8 (6) A3, Z = 4, Dx = 1 x 17 g cm-3, mu = 0 x 7332 cm-1, Mo K alpha radiation, lambda = 0 x 7107 A, F(000) = 896, T = 198 K, R = 0 x 0475 for 2460 reflections [Fo greater than or equal to 4 sigma(Fo)]. The assignment of the absolute configuration was based on internal comparison to the (-)-menthol moiety. The morpholenyl and cyclohexyl rings are in the chair conformation. The amide group is essentially planar [max. deviation 0.025 (2) A for N19] resulting in a close non-bonded contact between the amide oxygen, O18, and H24a of 2 x 24 (4) A.

Dipeptides↗
PubMed1991

Mental disorders among alcoholics. Relationship to age of onset and cerebrospinal fluid neuropeptides.

Eighty-one percent of 339 alcoholics participating in a research program were found to have associated mental disorders. Alcoholics with onset of heavy drinking before 20 years of age had significantly more antisocial personality traits, drug abuse, bipolar disorder, panic disorder, suicide attempts, and paternal alcoholism than alcoholics with onset after age 20 years. Alcoholics with onset before and after 20 years of age also differed significantly from each other for cerebrospinal fluid concentrations of diazepam-binding inhibitor and somatostatin. These results support the notion that age of onset may delineate subgroups of alcoholics with significant clinical and neurochemical differences.

Adult↗
PubMed1991

Depression among alcoholics. Relationship to clinical and cerebrospinal fluid variables.

Although depression is common among alcoholics, its determinants are poorly understood. Among 339 alcoholics, 111 (33%) had a history of major depression. Depressed, compared with never-depressed alcoholics, had a higher daily alcohol intake, more lifetime diagnoses of other anxiety and affective disorders and drug abuse, more had attempted suicide, and more reported alcoholism in both parents. Depressed alcoholics also had significantly lower cerebrospinal fluid levels of the dopamine metabolite homovanillic acid and of gamma-aminobutyric acid. Among subgroups of depressed alcoholics, secondary compared with primary depressives were more often divorced, of lower social status, with an earlier onset of alcoholism, and higher Michigan Alcohol Screening Test scores. Secondary depressives also had significantly lower cerebrospinal fluid concentrations of homovanillic acid than never depressed alcoholics. These results suggest that certain psychosocial variables, alcohol consumption, and neurochemical variables may be specifically associated with depression in alcoholics.

Adult↗
PubMed1990

Legal issues, AIDS, and the practicing physician.

This article highlights for the practicing physician some of the more important laws and regulations related to and arising from the AIDS epidemic. Medical-legal issues regarding the availability of health care as defined by federal and state law regarding employment and level of medical care given based on HIV status is discussed. Texas law regarding testing, disclosure of test results, and possible claims that could arise due to issues such as the invasion of privacy are examined along with criminal penalties for transmitting the virus to others, insurance, and insurability. Finally, the June 1989 Human Immunodeficiency Virus Services Act and Senate Omnibus Bill 959, which was passed into law, is briefly outlined.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Hypertension in sickle cell disease.

We report a young male with sickle cell trait who developed severe hypertension and splenic infarction soon after travel to a high altitude. Hypertension persisted for three days after a diagnostic laparotomy. His blood pressure then continued to be normal over the next one and a half years. Red cell sludging in the small vessels of the kidney possibly activated the renin angiotensin system.

Adult↗
PubMed1988

Menopause: some interpretations of the results of a study among a non-western group.

This paper presents an analysis and interpretation of the reasons that older immigrant Sikh women in a Canadian city perceive menopause as a positive event in their lives. Traditional psychological and psychosomatic symptoms ascribed to menopause in the literature were notably absent in this group of women. The positive attitude that the women displayed toward the menopausal experience was investigated within the ecology of their particular lives. Prior to and after immigration to Canada, participants lived in a traditional Indian/Sikh ideological setting. Only within this ideological system and world view could the cultural symbolism and the meaning ascribed to menopause be understood. The physical/biological symptoms and the meaning ascribed to them was not addressed (George T. There is a time for everything: A study of the menopausal/climacteric experience of Sikh women in Canada. Doctoral dissertation, University of Utah, 1985).

Adult↗
PubMed1987

Effectiveness of amiodarone on ventricular arrhythmias during and after acute myocardial infarction.

A randomized, placebo-controlled study examined the effect of amiodarone on the incidence of ventricular arrhythmias after acute myocardial infarction (AMI). Two hundred patients with AMI were randomized to receive amiodarone, 200 mg every 8 hours for 1 month, followed by 200 mg/day, or placebo, starting 48 hours after the onset of chest pain. Twenty-four-hour Holter monitoring was performed on day 1, repeated after 8 days and subsequently at 3-month intervals. One hundred seventy-two patients were followed for 6 to 42 months and monitor data were available at 6 to 9 months in 129 patients. Amiodarone was well tolerated, with no serious side effects; 12 patients were withdrawn from therapy. At 6 to 9 months more than 1 ventricular premature complex per hour was present in 3 of the 59 amiodarone-treated patients (5%) and 24 of the 70 placebo-treated patients (34%) (p less than 0.02). Complex arrhythmias (multifocal, early cycle, repetitive, bigeminy, trigeminy or ventricular tachycardia) were present in 5 of 59 of the amiodarone-treated patients (8%) and 20 of 70 placebo-treated patients (28%) (p less than 0.005). Sixteen patients in the amiodarone group and 11 in the placebo group died (difference not significant). Thus, amiodarone can reduce the frequency and complexity of ventricular arrhythmias after AMI, but it is unlikely that this will result in a substantial beneficial effect on post-AMI mortality risk.

Amiodarone↗
PubMed1987

Bradyrhizobium japonicum-Environment Interactions: Nodulation and Interstrain Competition in Soils along an Elevational Transect.

The effects of temperature and soil type on interstrain competition of Bradyrhizobium japonicum and on nodulation and nitrogen accumulation in five soybean varieties belonging to four maturity groups were investigated at three sites devoid of soybean rhizobia along an elevational transect in Hawaii. Competition patterns of the three B. japonicum strains were unaffected by soil type or soil temperature. Strain USDA 110 was the best competitor, occupying on the average 81 and 64% of the nodules in the field and greenhouse experiments, respectively. Strain USDA 138 was the least successful in the field (4%), although it formed 34% of the nodules in the greenhouse. Nodule occupancy by B. japonicum strains was found to be related to soybean maturity group. Strain USDA 110 formed 61, 71, 88, 88, and 98% of the nodules in the field on Clay (00), Clark (IV), D68-0099 (VI), N77-4262 (VI), and Hardee (VIII), respectively. Strain USDA 136b formed few nodules on Hardee, an Rj2 soybean variety incompatible with that strain, in both experiments. Nodule number and weight at the 1,050-m site were reduced to 41 and 27%, respectively, of those at the 320-m site because of the decrease in temperature. Nodule number increased with increasing maturity group number at each site; however, there was not a corresponding increase in nodule weight. Nitrogen accumulation decreased from 246 mg of N per plant at the lowest elevation site to 26 mg of N per plant at the highest elevation. While soil type and temperature had no effect on strain competition, temperature had a profound influence on nodule parameters and plant growth.

Journal Article↗
PubMed1986

Caloric intake necessary for weight maintenance in anorexia nervosa: nonbulimics require greater caloric intake than bulimics.

In the past decade, patients with anorexia nervosa have been subdivided by the presence or absence of binging-and-purging behavior. Psychologic, physiologic, and premorbid weight differences have also been discovered between these subgroups. We now report that nonbulimic anorectics required 30-50% more caloric intake than bulimic anorectics to maintain a stable weight. This difference in caloric intake was independent of phase of illness; it was present at low weight and at intervals after weight restoration. Subjects were closely supervised on an inpatient hospital ward so that they could not binge or purge. Motor activity did not appear to explain these alterations in caloric requirements. Such differences in caloric intake could be trait related or a consequence of many years of starving or binging behavior. These findings are clinically relevant for advising eating disorder patients of caloric requirements necessary to maintain a normal weight.

Adult↗
PubMed1985

Fluorescein angiographic studies of mebendazole treatment for onchocerciasis.

Mebendazole was compared to placebo treatment in a prospective double-masked study of the treatment of onchocerciasis. Twenty Ghanaian men were randomly assigned to one of two groups and received either mebendazole 2 G per day for 14 days preceded by 300 mg of levamisole in 2 doses or placebo vitamin tablets for 14 days. They were then followed for 12 months. Systemic side effects during the first 2 weeks of treatment were uncommon in each group. Similarly, ocular changes associated with a microfilaricidal action were infrequent. No fluorescein angiographic changes attributable to treatment appeared during the one-year follow up although there was progression of ocular disease in some men in each group. Skin microfilarial (mf) counts fell significantly in both groups at 1 week but returned toward pretreatment levels at 3 months and fell again by 12 months. At no time was there a difference between the placebo-treated control group and the mebendazole/levamisole group in terms of mf counts, ocular changes, clinical changes, biochemical parameters, nor was there a difference in the status of adult worms or embryogenesis assessed in nodules excised at 5 months. These results suggest that, in this study at least, mebendazole/levamisole was no more effective than placebo in treating onchocerciasis. Why mebendazole, which has been previously reported to both suppress embryogenesis and lower skin mf counts, had no effect in this study is unknown.

Adult↗
PubMed1983

High-resolution photography of the retinal nerve fiber layer.

Abnormalities in the appearance of the retinal nerve fiber layer can indicate the presence of optic nerve atrophy, but a major problem has been the difficulty of visualizing the nerve fiber layer in some individuals. By selectively illuminating the white nerve fiber layer in comparison with the red retinal pigment epithelium and choroidal background, red-free light increases the visibility of the nerve fiber layer. Compared with the standard red-free photographic technique, a 560-nm short-pass cut-off filter, used with extended-range, high-resolution, extremely fine-grain film (Kodak No. 2415 Technical Pan film), considerably enhanced the ability to resolve nerve fiber bundles.

Adolescent↗