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T Garcia

Publications and source records attributed to T Garcia.

45 records · Page 3Linked to original sources
PubMed1983

Protein kinase activity of purified components of the chicken oviduct progesterone receptor.

Preparations of the 90K and 110K components of the chick oviduct progesterone receptor (PR) purified to near homogeneity were tested for protein kinase activity. The 90K component was shown to incorporate radioactive phosphate from [gamma-32P]-ATP in the presence of Ca2+ but not of Mg2+ ions, while the 110K component was phosphorylated in the presence of Mg2+, but not of Ca2+. The enzymatic activity of the 90K polypeptide appeared selective, since added proteins (histones) did not become phosphorylated. However, all proteins present in the 110K preparations were phosphorylated in the presence of Mg2+. These data suggest that components of the chick oviduct PR display protein kinase activity.

Animals↗
PubMedDate not supplied

Chromosome abnormalities and sister chromatid exchanges in children with acute intoxication due to inhalation of volatile substances.

Deliberate inhalation of volatile substances is a common and harmful practice among young persons worldwide. Recently, we described chromosome damage in children who chronically inhale volatile agents. Clinical and cytogenetic studies were performed for 15 "sniffing" children (13 boys and 2 girls), the purpose of which was to define the chromosomal effect of the acute intoxication. A significant increase in the rate of chromosome abnormalities and in the frequency of sister chromatid exchanges (SCEs) was found in sniffers vs. controls. The values were also higher in children who were acutely intoxicated than in those who chronically inhaled volatile agents. Clinical, socioeconomic, and cytogenetic findings are also discussed.

Adolescent↗
PubMedDate not supplied

[The diversity of Staphylococcus aureus strains isolated in a Lisbon hospital over a 4-year period].

Over a 4-year period, 2020 Staphylococcus aureus strains isolated in Santa Maria Hospital were studied, 26.3% of which were methicillin-resistant (MRSA). The main specimens from which the strains were isolated included pus, blood and sputum/bronchial secretions. Isolation in blood cultures was the most common source among patients from medical units. Antimicrobial susceptibility studies showed that while in methicillin susceptible strains sensitivity to other antimicrobial agents (apart from penicillin resistance) was the rule, in MRSA strains there was resistance to most antibiotics. Only vancomycin was active against all strains. Phage typing showed that 75.5% of the strains were typable with phages at 100 x R.T.D. Among methicillin sensitive strains, a big diversity of phage patterns was observed, including phage groups I, II, III and V, as well as with phage association D11/95. The large majority of MRSA strains were lysed by group III phages, although several distinct patterns were observed. Within these strains, lysis by groups II and V phages was not observed. Plasmid profiling was the least discriminant issue in the characterization of these micro-organisms because most of the strains harboured only one plasmid (or none). These results showed that a dominant MRSA strain did not exist in this hospital, but rather several distinct strains. The importance, as well as the difficulties in controlling the spread of MRSA strains in the present conditions of high prevalence, are highlighted.

Bacteriophage Typing↗
PubMedDate not supplied

[Medullary and intracranial metastases of myxopapillary ependymoma].

After a brief introduction about the clinical, histological and therapeutic characteristics of myxopapillar spinal ependymoma of cone medullar and filum terminale, three cases with medullar and intracranial seeding of myxopapillar spinal ependymoma are retrospectively reviewed. Surgical resection was total in the child and partial in the adult cases and the histological results were myxopapillar. The diagnosis was made by CT and MRI between 1-2 months before surgical treatment. No extra-neural tumour was found. The mechanisms and factors that influence the seeding of this type of tumour are discussed. The most important literature is reviewed and the cases discussed. The authors stress the importance of surgery on prognosis and the need of an MRI of the whole neural-axis, particularly in children, and subtotal exeresis in adults.

Adult↗
PubMedDate not supplied

[Caudal regression syndrome. Lumbo-sacral agenesis].

Retrospective analysis of six cases of caudal regression syndrome, classified in accordance with vertebral envolvement. The degree of vertebral agenesis, morphology and topography of the conus medularis, neurologic implications (motor, sensitive and autonomous) and associated malformations, of particular importance in some situations of little significant vertebral agenesis are analyzed. Associations with eventual predisponent factors are sought.

Adolescent↗