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Biomedical subjects

T G Wilson

Publications and source records attributed to T G Wilson.

135 records · Page 8Linked to original sources
PubMedDate not supplied

Intracellular localization and tissue specificity of the Methoprene-tolerant (Met) gene product in Drosophila melanogaster.

The Methoprene-tolerant (Met) gene product in Drosophila melanogaster facilitates the action of juvenile hormone (JH) and JH analog insecticides. Previous work resulted in the cloning and identification of the gene as a member of the bHLH-PAS family of transcriptional regulators. A Met(+) cDNA was expressed in Escherichia coli, and polyclonal antibody was prepared against the purified protein. A single band on a Western blot at the expected size of 79kD was detected in extracts from Met(+) larvae but not from Met(27) null mutant larvae, demonstrating the antibody specificity. Antibody detected MET in all stages of D. melanogaster development and showed tissue specificity of its expression. MET is present in all cells of early embryos but dissipates during gastrulation. In larvae it is present in larval fat body, certain imaginal cells, and immature salivary glands. In pupae it persists in fat body cells and imaginal cells, including abdominal histoblast cells. In adult females MET is present in ovarian follicle cells and spermathecae; in adult males it is present in male accessory gland and ejaculatory duct cells. In all of these tissues MET is found exclusively in the nucleus. Some of these tissues are known JH target tissues but others are not, suggesting either the presence of novel JH target tissues or another function for MET.

Animals↗
PubMedDate not supplied

Periodontal diseases and diabetes.

Inflammatory periodontal diseases are common in the United States. The incidence of gingivitis and periodontitis appears to be the same for persons with controlled diabetes as for those in the nondiabetic population. For patients with uncontrolled diabetes, however, periodontal diseases progress more rapidly than in their controlled counterparts. In addition, once a person with diabetes has periodontitis, the disease is usually more aggressive than in nondiabetic controls. These differences may be due to microangiopathy, altered polymorphonuclear leukocyte chemotaxis, increased dental plaque formation, or other causes. Patients with diabetes should be counseled to have a periodontal screening, which must include the use of a probe to measure the depth of the periodontal pockets. When problems are found, they should be treated and the patient should be placed in maintenance therapy.

Diabetes Complications↗
PubMedDate not supplied

Multicenter retrospective analysis of the ITI implant system used for single-tooth replacements: results of loading for 2 or more years.

This report involves the retrospective evaluation of ITI implants placed by a group of 12 clinicians located throughout the United States. Of the original 174 single implants placed in 129 patients reported previously, 157 were examined in 110 patients after 2 or more years (average 40.1 months). Twenty-two implants remained in the anterior and 135 implants (86%) remained in the posterior areas of the mouth, with 81 being restored with an octabutment screw-retained crown and 76 restored with a conical-abutment cemented crown (in function 2 years or longer). Occlusal screw loosening was observed in 22.2% of implants over both periods, with only 1 tooth loosening in both study periods (6 months to 2 years and > or = 2 years). Loosening of a solid conical abutment occurred in 1 additional patient, for cumulative conical abutment loosening of 5.3%. Significant radiographic bone loss was observed around 4 implants, with implant fracture noted with 3 additional implants (all mandibular first molars with hollow-screw or hollow-cylinder implant design). The survival rate at > or = 2 years was 95.5%. The data suggest that ITI implants can be a satisfactory choice for posterior single-tooth restorations.

Alveolar Bone Loss↗
PubMedDate not supplied

Not all patients are the same: systemic risk factors for adult periodontitis.

Periodontal diseases are viewed today as multifactoral problems that are initiated and sustained by bacteria but significantly modified by the body's response to bacterial plaque. Local and systemic risk factors are involved in the disease process and both should be included when prognosis and treatment plans are developed. The most significant systemic modifying factors appear to be smoking, diabetes, and a recently discovered genetic marker. Slight changes in genes that produce an important inflammatory mediator, found in one-third of those studied, can lead to major negative outcomes in the way the body responds to bacteria.

Adult↗
PubMedDate not supplied

Clinical effectiveness of 1 and 2% lidocaine in young pediatric dental patients.

Clinical effectiveness of the double-blind administration of 1 and 2% lidocaine solutions was evaluated for restorative and surgical procedures on primary molars of children 4.5 to 10.5 years old. This effectiveness was measured by changes in the child's heart rate, the child's self report of pain, and the operator's assessment of the anesthesia's effectiveness. Although the incidence of anesthetic failure was higher for the 1% solution (31.3%) than for the 2% solution (11.1%), no statistically significant difference between the solutions was found. During the performance of pulpotomies and extractions, a higher failure rate was recorded for the 1% solution (62.5%) than for the 2% solution (28.6%), but these differences were not statistically significant. For minor restorative procedures, the 1% solution was equally successful in achieving anesthesia. The results suggested that 1% lidocaine should be used when multiple minor procedures are performed and potential toxicity in the young dental patient is a concern.

Anesthesia, Dental↗
PubMedDate not supplied

Three-dimensional templates for placement of root-form dental implants: a technical note.

This report describes a method for gathering information to assist in properly placing dental implants. A diagnostic template is first fabricated, incorporating radiographic markers. Radiographs of the template are obtained, and data from their study are transferred to the laboratory to facilitate the fabrication of a surgical template. This procedure has the potential to map implant sites three dimensionally. Template use can result in a greater number of implants placed in optimal positions.

Contrast Media↗
PubMedDate not supplied

A multicenter retrospective analysis of the ITI implant system used for single-tooth replacements: preliminary results at 6 or more months of loading.

This report involves the retrospective evaluation of ITI implants placed by a group of 12 clinicians located throughout the United States. Of the 174 single implants placed in 129 patients, 151 implants (86.8%) were placed in posterior regions, and 23 were placed in anterior regions; 54.6% of the implants had a length of 10 mm or less. Ninety-two implants were restored with a screw-retained crown, and 82 were restored with a cemented crown (in function 6 months or longer). The survival rate at 6 months was 97.7%. Occlusal screw loosening had an 8.7% occurrence rate (no repeated loosening), and solid conical abutment loosening had a 3.6% occurrence rate (all in one patient). Significant radiographic bone loss was observed on 2.3% of the implants. Data suggest that ITI implants can be a satisfactory choice for posterior single tooth restorations.

Adolescent↗
PubMedDate not supplied

Implants placed in immediate extraction sites: a report of histologic and histometric analyses of human biopsies.

Five titanium plasma-sprayed implants were biopsied from a human volunteer 6 months after placement. Four test implants had been placed in immediate extraction sockets, while one implant was placed in a mature site and served as a control. The histologic analysis demonstrated that all five implants achieved osseointegration as demonstrated by light microscopy, whereas a varying degree of bone-implant contact was observed. The non-loaded control implant had the highest percentage of bone-implant contact, 72%, followed by the two implants placed in the canine sites presenting with a horizontal defect dimension of 1.5 nm or less. These implants were placed without a barrier membrane, but in a submerged fashion. The histometric analysis showed a mean bone-implant contact of 50% for these two implants. The lowest mean bone-implant contact (17%) was observed for the two molar implants, which had horizontal defect dimensions of 4 mm; these implants were placed in a non-submerged fashion with the implants perforating an expanded polytetrafluoroethylene membrane. The authors concluded that osseointegration may occur in immediate extraction sites in humans using titanium implants with a plasma-sprayed surface. The horizontal component of the peri-implant defect was apparently the most critical factor relating to the final amount of bone-implant contact.

Alveolar Process↗