Biomedical subjects

T G Wilson

Publications and source records attributed to T G Wilson.

At least 91 records · Page 5Linked to original sources

PubMed1991

Radiographic assessment of blunt renal trauma.

Recent reports in the urologic literature suggest that radiographic evaluation of normotensive blunt trauma patients with microscopic hematuria is no longer necessary. Several facilities, however, including the Los Angeles County-University of Southern California Medical Center continue to routinely perform intravenous pyelography in this setting. To further evaluate whether this practice is indicated, we retrospectively reviewed the records of 337 patients seen at our facility between May, 1986 and December, 1989 following blunt trauma with resultant microscopic hematuria but no shock. All patients were radiographically assessed with an intravenous pyelogram. Of the 337 studies, 30 (9%) had an abnormal result, including 28 renal contusions, 1 ureteropelvic junction (UPJ) disruption, and 1 non-functioning kidney (which on further evaluation revealed a congenitally absent kidney). A total of 1 significant urologic injury was identified. Thus, only one injury (0.3%) would have been missed if a policy of observation was followed in this group of patients. Our data support other reports in the urologic literature that radiographic staging is not necessary in managing blunt trauma patients with microscopic hematuria but no shock.

Adolescent↗

PubMed1991

Percutaneous biopsy of bladder-drained pancreas transplants.

Percutaneous biopsy is a valuable investigation in the management of allograft rejection for all solid organs. Pancreas transplants have not been biopsed percutaneously, though open and percystoscopic biopsies have proved useful. We have compared percutaneous needle core biopsy with fine-needle aspiration cytology for the diagnosis of rejection in 18 patients receiving combined kidney and pancreas transplants and in one who was transplanted with the pancreas alone. Percutaneous needle core biopsy was successful in 37 of 40 attempts (93%), while fine-needle aspiration yielded diagnostic material on 33 of 47 attempts (70%). Transient hyperamylasemia occurred in 29%, returning to baseline in three days. One patient twice developed transient macroscopic hematuria. There was agreement between needle core biopsy and fine-needle aspiration on the diagnosis of rejection on six occasions and for the absence of rejection on 16. There was an 8% false-positive rate for fine-needle aspiration. In 13 instances of histologically proved renal rejection, concurrent pancreas biopsy revealed rejection in 69%. Pancreas rejection was not, however, seen in the absence of renal rejection. In this pilot study, percutaneous biopsy of the bladder-drained pancreas allograft was shown to be a practicable and valuable investigation without major complications.

Adult↗

PubMed1991

Supportive periodontal treatment: maintenance.

An increasing emphasis is being placed on the phase following active therapy for inflammatory periodontal diseases. This phase of therapy, once termed maintenance, is now called supportive periodontal therapy (SPT) (American Academy of Periodontology, Current Procedural Terminology for Periodontics. 5th American Academy of Periodontology, 1986). Supportive periodontal therapy has been shown to have an important role in controlling periodontal problems. However, most patients do not comply with suggested SPT intervals.

Continuity of Patient Care↗

PubMed1990

Evidence for a juvenile hormone receptor involved in protein synthesis in Drosophila melanogaster.

The larval fat body of newly eclosed adults of Drosophila melanogaster was found to contain a single major binding protein specific for juvenile hormone (JH). Binding to this protein was saturable, of high affinity, and specific for JH III. The protein has a subunit molecular weight (Mr) of 85,000, as determined by photoaffinity labeling. The same or similar JH-binding protein was found in larval fat body and cuticle of third instar larvae and in male accessory glands and heads of newly eclosed adults. It was not found in several other tissues in adults. Male accessory gland cytosol from wild-type flies was found to contain a single binder with a dissociation constant (KD) of 6.7 nM for JH III; a binder in similar preparations from the methoprene-tolerant (Met) mutant had a KD value 6-fold higher. JH III stimulated protein synthesis in glands cultured in vitro, but this effect was reduced in Met flies as compared to wild-type flies, establishing a correlation between JH binding and biological activity of the hormone. In addition, glandular protein accumulation during the first 2 days of adult development was less in Met flies than in wild-type flies. These results strongly suggest that the binding protein we have identified mediates this JH effect in male accessory glands and thus is acting as a JH receptor.

Adipose Tissue↗

PubMed1990

Resistance to juvenile hormone and an insect growth regulator in Drosophila is associated with an altered cytosolic juvenile hormone-binding protein.

The Met mutant of Drosophila melanogaster is highly resistant to juvenile hormone III (JH III) or its chemical analog, methoprene, an insect growth regulator. Five major mechanisms of insecticide resistance were examined in Met and susceptible Met+ flies. These two strains showed only minor differences when penetration, excretion, tissue sequestration, or metabolism of [3H]JH III was measured. In contrast, when we examined JH III binding by a cytosolic binding protein from a JH target tissue, Met strains had a 10-fold lower binding affinity than did Met+ strains. Studies using deficiency-bearing chromosomes provide strong evidence that the Met locus controls the binding protein characteristics and may encode the protein. These studies indicate that resistance in Met flies results from reduced binding affinity of a cytosolic binding protein for JH III.

Adipose Tissue↗

PubMed1990

Maintaining periodontal treatment.

Dental maintenance, or supportive periodontal treatment (SPT), can keep the periodontium and peri-implant tissues healthy after active therapy. Patients who comply to suggested SPT fare better periodontally and keep their teeth longer. Data should be gathered by examinations, talking with patients, and reviewing personal oral hygiene. Then sub- and supra-gingival deposits should be removed. The average SPT visit should last 1 hour and should be scheduled every 3 months. Supportive periodontal treatment for patients with more advanced periodontal or peri-implant destruction should be the responsibility of the periodontist.

Aftercare↗

PubMed1990