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Biomedical subjects

T G Stinchcomb

Publications and source records attributed to T G Stinchcomb.

4 recordsLinked to original sources
PubMed1979

Calculations of charged-particle recoils, slowing-down spectra, LET and event-size distributions for fast neutrons and comparisons with measurements.

A rapid system has been developed for computing charged-particle distributions generated in tissue by any neutron spectra less than 4 MeV. Oxygen and carbon recoils are derived form R-matrix theory, and hydrogen recoils are obtained from cross-section evaluation. Application to two quite different fission-neutron spectra demonstrates the flexibility of this method for providing spectral details of the different types of charged-particle recoils. Comparisons are made between calculations and measurements of event-size distributions for a sphere of tissue 1 micrometer in diameter irradiated by these two neutron spectra. LET distributions have been calculated from computed charged-particle recoils and also derived from measurements using the conventional approximation that all charged particles traverse the chamber. The limitations of the approximation for these neutron spectra are discussed.

Carbon↗
PubMedDate not supplied

Obtaining S values for rectangular-solid tumors inside rectangular-solid host organs.

A method is described for obtaining S values between a tumor and its host organ for use with the MIRD formalism. It applies the point-source specific absorbed fractions for an infinite water medium, tabulated by Berger, to a rectangular solid of arbitrary dimensions which contains a rectangular tumor of arbitrary dimensions. Contributions from pairs of source and target volume elements are summed for the S values between the tumor and itself, between the remaining healthy host organ and itself, and between the tumor and the remaining healthy host organ, with the reciprocity theorem assumed for the last. This method labeled MTUMOR, is interfaced with the widely used MIRDOSE program which incorporates the MIRD formalism. An example is calculated.

Humans↗
PubMedDate not supplied

Analytic microdosimetry for radioimmunotherapeutic alpha emitters.

Analytic microdosimetry using Fourier transform techniques has been applied to internal alpha emitters. These techniques need revision and simplification for use with short-lived radionuclides such as those which may be useful for radioimmunotherapy. Analytic methods may have advantages over Monte Carlo methods in some cases (e.g., where time is important). Applications to eight different source geometries show the usefulness of these techniques. Comparisons of some of the results of Monte Carlo calculations prove its accuracy. For a uniform source of 5.867-MeV alphas spread throughout the volume outside a cell surface, the two methods agree well. Results are within 1% both for the average specific energy and for the number of hits. Analytic microdosimetry provides an alternate method to use for the critical evaluation of models that seek to predict the relation between alpha energy deposition and cell survival data. Similarly, it may be helpful to point the way toward the rational interpretation of general biological results for antibodies labeled with alpha emitters.

Alpha Particles↗