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Biomedical subjects

T G Olsen

Publications and source records attributed to T G Olsen.

28 records · Page 2Linked to original sources
PubMed1979

Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid.

Fourteen patients with treatment-resistant cystic and conglobate acne were treated for four months with oral 13-cis-retinoic acid, a synthetic isomer of naturally occurring all-trans-retinoic acid. The average dose was 2.0 mg per kilogram per day. Thirteen patients experienced complete clearing of their disease; the other had 75 per cent improvement, as determined by the number of acne nodules and cysts present before and after therapy. Prolonged remissions, currently lasting as long as 20 months after discontinuation of therapy, have been observed in all 14 patients. Clinical toxicity was limited to the skin and mucous membranes in most patients and was dose dependent and rapidly reversible upon discontinuation of therapy. The mechanism of action of 13-cis-retinoic acid in the therapy of acne probably involves a direct inhibitory effect of the drug on the sebaceous gland.

Acne Vulgaris↗
PubMed1979

Blepharoconjunctivitis: a side effect of 13-cis-retinoic acid therapy for dermatologic diseases.

Blepharoconjunctivitis developed as a side-effect of treatment of patients with basal cell carcinomas, keratinizing dermatoses, and cystic acne with oral 13-cis-retinoic acid. Forty-two of the 97 dermatologic patients had signs and symptoms of blepharoconjunctivitis that were dose related and abated one week after discontinuation of the medication. About half of the patients had a history of similar symptoms prior to treatment. Staphylococcus aureus was present in eye cultures of 73% to 79% of the patients, whether symptomatic or not. Patients whose clinical appearance was that of staphylococcal blepharoconjunctivitis and whose cultures grew S aureus were successfully treated with topical erythromycin ointment to the lids even while being treated with the 13-cis-retinoic acid.

Acne Vulgaris↗
PubMed1979

Subcorneal pustular dermatosis and crippling arthritis.

A 25-year-old woman has suffered with subcorneal pustular dermatosis and a rheumatoid-like arthritis for the past 11 years. Both her skin lesions and arthralgia have abated with institution of dapsone administration and have worsened with interruption or reduction of the dose. The coexistence of arthritis and subcorneal pustular dermatosis and the response of both to therapy suggest a probable association.

Adult↗
PubMed1979

Laser surgery for blue rubber bleb nevus.

A 21-year-old man has had extensive cutaneous and visceral manifestations of the blue rubber bleb nevus syndrome since birth. Surgical therapy with the carbon dioxide laser was successful in removing 225 skin hemangiomas without recurrences or complications such as hemorrhage and infection. The cosmetic and follow-up results have been excellent.

Adult↗
PubMed1978

Lupus band test.

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Antibodies, Antinuclear↗