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Biomedical subjects

T G Matthews

Publications and source records attributed to T G Matthews.

At least 55 records · Page 3Linked to original sources
PubMed1986

'Near miss' sudden infant death and obstructive apnoea.

A 4 month old girl presented with a 'near miss' sudden infant death episode for which no cause was found. Obstructive sleep apnoea syndrome subsequently developed. All symptoms ceased after adenoidectomy at age 9 months.

Adenoidectomy↗
PubMed1985

Hypolipidemic activity of the surfactants aminimides, and their effects on lipid metabolism of rodents.

A series of short chain fatty acid derivatives of aminimides were shown to possess hypolipidemic activity in rats and mice. Most of the agents tested lowered both serum cholesterol and triglyceride levels by at least 30% in mice and were effective in hyperlipidemic induced mice. 1,1-Dimethyl-1-(2-hydroxypropyl)-amine mersitimide lowered serum cholesterol levels 41% and serum triglyceride levels 56% at 20 mg/kg/day I.P. after 16 days. The same agent was active orally when administered to rats with a 38% reduction in serum cholesterol and a 52% reduction in serum triglycerides after 14 days. The agents inhibited liver acetyl CoA synthetase, ATP dependent citrate lyase and phosphatidate phosphohydrolase activities in vitro and in vivo. Reduction of cholesterol, triglycerides, neutral lipids and phospholipid levels were noted in the livers of mice treated for 16 days. In rat studies, cholesterol, triglyceride and phospholipid levels were reduced in liver, small intestine and the feces after two weeks' dosing. The cholesterol content was reduced in the very low density lipoprotein (VLDL) and low density lipoprotein (LDL) fractions but elevated in the high density lipoproteins (HDL). Triglyceride levels were lowered in the VLDL, and neutral lipid levels were reduced in the chylomicron and VLDL fractions.

ATP Citrate (pro-S)-Lyase↗
PubMed1985

Early seizures indicate quality of perinatal care.

An analysis of antepartum, intrapartum, and postpartum variables was performed in a retrospective controlled study of 34 normally formed term infants who had perinatal asphyxia and subsequently displayed generalised seizures within 48 hours of birth. The aim was to identify any association, firstly between these variables and seizures, and secondly between these variables and subsequent morbidity and mortality among the seizure group. Maternal age greater than 35 years, duration of labour, meconium stained liquor, abnormal intrapartum fetal heart rate trace, and operative delivery were associated with seizures. A low Apgar score at five minutes, and intermittent positive pressure ventilation at birth of longer than 10 minutes were associated with subsequent morbidity and mortality. A striking relation between poor intrauterine growth and either death or handicap in the asphyxia group emphasised the value of growth measurements as a predictor of outcome. The overall incidence of seizures was 1.6 per 1000 term deliveries. There was a significant correlation between the seizure incidence and the intrapartum mortality rate. The incidence of seizures secondary to asphyxia in term infants, occurring less than 48 hours after delivery, may be a valuable index of the quality of perinatal care.

Adolescent↗