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Biomedical subjects

T G Brien

Publications and source records attributed to T G Brien.

34 records · Page 2Linked to original sources
PubMed1971

Potassium-sparing agents during diuretic therapy in hypertension.

Three pharmacological agents in use as "potassium-sparing" drugs have been tested by serial measurements of total exchangeable potassium (K(E)) during 4 to 12 weeks of oral diuretic therapy in hypertensive subjects. Triamterene seemed ineffective in the dosage used (50 mg twice daily). Spironolactone (25 mg twice daily) reduced K loss to a considerable extent, while Slow-K (32 mEq daily) completely reversed previous K(E) deficits. Plasma K levels were a poor indication of degree of K(E) restoration.

Adult↗
PubMed1970

Body composition changes in hypertensive subjects on long-term oral diuretic therapy.

Hypertensive patients were treated with either chlorthalidone or frusemide for periods of two to four months. Reduction in blood pressure was seen with chlorthalidone but not with frusemide. This hypotensive effect appeared to be independent of the natriuretic effect.A significant reduction in total exchangeable potassium (K(E)) was seen with both agents, but no patient showed adverse symptoms or signs. There was no alteration in maximal urinary concentration or acidification, or in intravenous glucose tolerance or plasma insulin. It is concluded that potassium depletion of this degree does not require replacement therapy on a routine basis in hypertensive patients.

Adult↗
PubMedDate not supplied

Testicular activity in mice selected for increased body weight.

Parameters of testicular function were studied in mice selected for increased body weight and in contemporaneous unselected controls. Spermatogenesis occurred at the same time in the two lines. Body weight, testis weight, mean seminiferous tubular diameter and serum testosterone were increased significantly in the high growth mice. It is suggested that some genetically determined differences in body size are brought about by the differential secretion of testosterone.

Age Factors↗
PubMedDate not supplied

The effects of orchidectomy and the role of testosterone in determining the growth of male mice selected for increased body weight.

Male mice selected for increased body weight and unselected controls were compared with intact littermates at 10 weeks of age following bilateral orchidectomy at 21 days post partum. Castrated mice were lighter in both lines and orchidectomy abolished approximately half the increase in body weight brought about by selection. The lungs were unaffected but there were decreases in the weights of the heart, liver and kidney and of the biceps brachii and tibialis anterior muscles in both lines. The decreases in body weight, organ weight and muscle weight, both absolute and relative, were greater in high growth than in unselected mice. Orchidectomy affected the size but not the number of cells in the liver and kidney. These results support the hypothesis that the increased level of circulating testosterone reported previously in male mice selected for increased body weight is responsible for that proportion of their greater body weight which is attributable to increased cell size.

Animals↗