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Biomedical subjects

T G Bauer

Publications and source records attributed to T G Bauer.

5 recordsLinked to original sources
PubMed2000

Lung biopsy.

There are many techniques that can be used to arrive at a diagnosis in dogs and cats with signs referable to the pulmonary system. Biopsy of the pulmonary parenchyma remains the technique of choice when a diagnosis is absolutely required; it is also the technique with the greatest potential for serious complications during and after the procedure. This potential caused most veterinarians to refrain from performing biopsy in the majority of their respiratory cases. Nevertheless, newer, sophisticated biopsy equipment and techniques are now available, with lower complication rates. As more veterinarians become comfortable with this technology, pulmonary biopsy will become more commonplace, and more definitive diagnosis will be obtained. This will benefit the client, the patient, the practitioner, and the profession.

Animals↗
PubMed1995

[Food intake of dairy cows and heifers in late pregnancy during feeding of maize silage].

The influence of restricted (covering requirements) or ad libitum supply of maize silage in late pregnancy on feed intake was tested in two experiments with totally 51 dairy cows with several calvings (V1, V2 and in one experiment with 14 heifers (V3). Experimental time were the last 8 weeks before the expected calving date and was equivalent to the dry period of the cows. With adjusted feeding for energy requirement as a restricted supply the cows in V1 and V2 consumed 5.73 vs. 5.64 kg DM maize silage/animal and day, with ad libitum supply the intake of maize silage was substantial higher with an average of 9.65 vs. 9.85 kg DM/animal and day. With adjusted feeding for energy requirement as a restricted supply the heifers in V3 consumed 4.77 kg DM maize silage/animal and day. With ad libitum supply, however, the daily maize silage intake of heifers was substantial more with 7.00 kg DM/animal. With ad libitum feeding the mean daily intake of maize silage was unchanged in the weeks 8 to 3 before calving and decreased very strong in the cow experiments (V1, V2) in the last two weeks before calving and in the heifers experiment (V3) in the last week before calving. With restricted feeding the intake of maize silage was nearly unchanged until calving, only the cows in V1 showed a slight decrease in the last week before calving. With ad libitum feeding of maize silage in late pregnancy until 2 weeks before calving the cows and heifers reached a net energy intake of about 80 vs. 62 MJ NEL/day, which corresponded to 160% (V1, V2) vs. 135% (V3) of the energy requirement. The overconsumption for the crude protein was slighter with 120 to 140% of requirement.

Animals↗
PubMed1984

Constrictive pericardial disease in the dog.

The clinicopathologic features of constrictive pericardial disease in 13 dogs were reviewed. The causes were infection (3 dogs), metallic foreign body (1 dog), and idiopathic (9 dogs). Owner complaints included abdominal enlargement, tachypnea, weakness or syncope, exertional fatigue, and weight loss. Ascites and jugular venous distention were consistently observed, whereas abnormalities of arterial pulses and heart sounds were variable and inconsistent. Diminished QRS voltages were common. Mild to moderate cardiomegaly, rounding of the cardiac silhouette, and variable and nonspecific angiographic findings were frequently observed. Cardiac catheterization consistently showed elevation and equilibration of atrial and ventricular diastolic pressures, but a prominent early diastolic (y) descent was uncommon. Fibrosis was confined to the parietal pericardium in 8 dogs, and included the epicardium in 5 dogs. Parietal pericardectomy was successful in relieving the syndrome in 6 of 10 dogs. Pulmonary thrombosis was the most common cause of early postoperative mortality.

Animals↗
PubMed1975

Pharmacokinetic properties of ethosuximide in monkeys. I. Single-dose intravenous and oral administration.

The pharmacokinetic profile of ethosuximide was studied in 6 chronically catheterized male rhesus monkeys at three dose levels (30, 60, and 90 mg/kg), intravenously and orally. Plasma and urine levels were assayed by GLC. The intravenous and oral kinetics of ethosuximide were described in terms of a one-compartment open model with first-order elimination (and first-order absorption for oral kinetics). Volume of distribution (overall mean +/- SD=0.80 +/- 0.09 liters/kg), total body clearance (overall mean +/- SD= 19.2 +/- 2.70 ml/hr/kg) and elimination half-life (overall mean +/- SD=28.98+/-3.35 hr and 28.10+/-3.17 hr following intravenous and oral administration, respectively) remained constant over the dosage range Appendix) was selected to describe the disposition of ethosuximide in monkeys. Accordingly, plasma concentrations of individual animals and the average concentrations of Fig. 1 were fitted to a monoexponential equation [Eq. (A1)]. A close agreement between experimental datum points and least-squares fit lines was observed at all three dose levels. Plots of C0 and area under the plasma concentration-time curve [AUC, measured by trapezoidal rule, Eq. (A3)] vs dose (Fig. 4) were linear as predicted by Model I. It may be concluded, therefore, that a one-compartment open model with first-order elimination is appropriate to describe the intravenous kinetic behavior of ethosuximide in monkeys. The volume of distribution (overall mean +/- SD = 0.80 +/- 0.09 liters/kg) observed in the present study is higher than total body water and therefore suggests accumulation of ethosuximide in body tissues. Tissue distribution studies have not been performed in monkeys. However, data on tissue/plasma ratios in rats (Dill et al., 1965; Chang et al., 1972) indicate that ethosuximide can partition outside the total body water compartment. This behavior is compatible with the high pKa value and negligible protein-binding characteristics of ethosuximide (Chang et al., 1972). As discussed by several workers (Levy, 1968; DiSanto and Wagner, 1972; Lockard et al., 1974), the establishment of dose independency in elimination processes (kinetic linearity) requires that single-dose studies be performed at several dose levels. In the dose range examined in the present study (30 to 90 mg/kg), there was no evidence of dose-dependent elimination kinetics after intravenous or oral administration. The overall mean (+/- SD) elimination half-life (28.5 +/- 3.24 hr) obtained in the present study is somewhat longer than the value (22.0 hr) observed by Chang et al. (1972) following a single-dose (100 mg/kg) oral administration of ethosuximide in 4 rhesus monkeys. In view of the agreement between the predictions of Model I and experimental intravenous data, a one-compartment open model with first-order absorption and elimination processes (Model II, Appendix) was studied. The bioavailability of the syrup formulation used in the oral studies was essentially complete (overall mean +/- SD=96% +/- 12.0) and dose-independent...

Administration, Oral↗