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Biomedical subjects

T Furuyama

Publications and source records attributed to T Furuyama.

At least 91 records · Page 5Linked to original sources
PubMed1980

Morphological changes in an early phase of norepinephrine-induced acute renal failure in unilaterally nephrectomized dogs.

The morphological factors contributing to the reduction GFR in an early phase of NE-induced ARF (0.75 microgram/kg/min) were evaluated by comparing renal morphology at the end of NE infusion with that 2 hr later in unilaterally nephrectomized dogs. GFR 2 hr after NE infusion was reduced to 50% of the preinfusion level in a 30 min infusion group (N = 6), to 13% in a 60 min infusion group (N = 7), and to 2% in a 120 min infusin group (N = 5). On the other hand, simultaneous RBF was not significantly reduced in any group. Dilated PT lumina filled with eosinophilic granular materials in paraffin sections fixed in Zenker-Formol or with impacted swollen blebs in Epon sections fixed in diluted Karnovsky's solution and osmium were found diffusely immediately following 60 and 120 min NE infusion, but patchily after 30 min infusion. Similar changes were found 2 hr after the infusion, except that some PTs came to have dilated but transparent lumina in the 60 and 120 min NE infusion groups. Electron microscopic studies revealed that a part of the membrane-bounded cytoplasm of PT cells extruded into the tubular lumen and became impacted swollen blebs during NE-induced ischemia. There was no prominent foot process fusion in any group. It is concluded that the tubular obstruction by impacted swollen blebs generated in PT during ischemia is a major factor responsible for the reduction in GFR in the early phase of NE-induced ARF.

Acute Kidney Injury↗
PubMed1978

Passive hemagglutination and hemolysis tests for the detection of anti-DNA antibody.

Passive hemagglutination (PHA) and hemolysis (PHL) tests using chromium chloride-treated sheep red blood cells were developed to detect and measure the anti-DNA antibodies. Sonication of native DNA was found to prevent the incidence of non-specific agglutination. Sheep red cells were coated with double-stranded DNA (dsDNA) which had been sonicated and treated with nuclease S1 to digest the single-stranded regions in the DNA. The specificities for dsDNA-coated cells were checked by inhibition studies in PHA test and plaque assay. In clinical studies fairly close correlations were found between the antibodies to DNA and the activity of the disease in patients with systemic lupus erythematosus (SLE). Complement-fixing antibodies were detected in most of SLE patients with active lupus nephritis, but rarely in those in remission. Anticomplementary activity seemed to be negligible in PHL test. These tests are simple and may be useful to the diagnosis and the management of SLE.

Animals↗
PubMed1978

Plasma renin activity in acute renal failure induced by norepinephrine infusion in unilaterally nephrectomized dogs.

Plasma renin activity was determined by bioassay prior to, during and following a 2-hour infusion of norepinephrine into the renal artery in unilaterally nephrectomized dogs in order to examine the role of renin-angiotensin system in norepinephrine-induced ARF. ARF was induced in 5 of 8 dogs receiving 0.75 microgram/kg/min of norepinephrine, but not in the remaining 3 dogs and 2 dogs infused with 0.6 and 0.4 microgram/kg/min of norepinephrine. There proved no difference in plasma renin activity in renal venous blood between the dogs with and without ARF when followed up to 2 h after the discontinuation of the infusion. The same results were obtained when the plasma renin activity in the foreleg vein was followed at 24, 48 and 72 h after the infusion. The renin-angiotensin system does not seem to contribute to the reduction of renal function in norepinephrine-induced ARF in dogs.

Acute Kidney Injury↗
PubMed1975

Circulating plasma volume and renal function.

The relationships of circulating plasma volume (PV) to effective renal plasma flow and glomerular filtration rate (GFR) were investigated in reference to their interrelated changes induced by upright posture in normal subjects and patients with chronic glomerulonephritis. The following relation was obtained: (percentage change in GFR) = k(percentage change in PV). The values of k were 3.4 for the normal and 3.1 for the patients. There was no statistically significant difference between the two. On account of the above relation the recumbent level of glomerular filtration rate (GFR)r was derived from the recumbent level of circulating plasma volume (PV)r as follows: (GFR)r = Kp [(PV)r]k, where Kp is a constant. On the other hand, the decreases (percentage) in effective renal plasma flow were biphasically related to those in PV. Mean arterial pressure rose in upright posture in many cases, but its changes (percentage) showed no correlation with the changes (percentage) in GFR. These results suggest that in a small decrease in PV, GFR does not decrease with the fall in mean arterial pressure, but with the power function of PV. The possible mechanisms of these changes in renal function are examined with special reference to the structure of renal arterial system.

Adolescent↗
PubMed1975

Relationship between insulin response to oral glucose load and creatinine clearance.

In order to investigate the relationship between insulin response to oral glucose load and renal function, a 100-gm. oral glucose tolerance test was performed in twenty-two patients with chronic glomerulonephritis, whose creatinine clearances ranged form 5 to 96 ml. per minute. Glucose areas during oral glucose load were little affected by the creatinine clearance in this study. Insulin area during oral glucose load increased in proportion to the decrease in creatinine clearance. The ratio of insulin area to glucose area correlated closely with creatinine clearance and a linear relationship was obtained (y = 1.46 - 0.01x, r = -0.82, p less than 0.001). There were also significant correlations with serum creatinine, blood urea nitrogen, and PSP (r = 0.6, 0.63, and -0.62, respectively). These results show that the impaired renal function has a significant influence on the plasma insulin levels, and it seems likely that such influence becomes manifest below approximately 60 ml. per minute of creatinine clearance.

Adolescent↗