Metabolic studies of aminopyrine in rat and man by using stable isotope tracer techniques.
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Biomedical subjects
Publications and source records attributed to T Furuta.
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A close resemblance in fine structure was observed between the aganglionic colon, produced in rats by serosal application of 0.1% benzalkonium chloride solution, and the aganglionic descending colon, or more proximal segments, of Hirschsprung's disease. The pathogenesis of the disease is discussed.
Intestinal aganglionosis produced by serosal application of 0.1% benzalkonium solution to the colon of the rat was studied electronmicroscopically, and it was concluded that a higher susceptibility to the agent and a lower recovering ability of the nerve elements might be responsible for the phenomenon.
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Electrophysiological studies were performed in five patients, two with the three without Wolff-Parkinson-White (WPW) syndrome. In the former patients group, the paroxysmal supraventricular tachycardia (PSVT) was concluded to reflect the circus movement utilizing the normal atrioventricular (A-V) conduction system for antegrade conduction and the Kent bundle for the retrograde conduction. Ventriculoatrial conduction time (VACT) was measured during ventricular pacing before and after the administration of atropine sulfate. In patients without WPW syndrome, the VACT prolonged and subsequently second degree ventriculoatrial block developed when the pacing rate was increased progressively and atropine facilitated the retrograde conduction, suggesting the ventriculoatrial conduction took place via the normal A-V pathway. In contrast, the VACT in patients with WPW syndrome remained unchanged during ventricular pacing at rates of 145/min and more before and after atropine, indicating the retrograde conduction was taking place through the Kent bundle. It is discussed that the analysis of the VACT before and after atropine serves as an aid to differentiate the underlying mechanisms of PSVT in patients with WPW syndrome.
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The possibility of radioisotope X-ray absorptiometry to determine the particle size of powder in conjunction with sedimentation was investigated. The experimental accuracy was primarily determined by Cow and X-ray intensity. where Co'=weight concentration of the particle in the suspension w'=(micron/rho)l/(mu/rho)s-rhol/rhos rho; density micron/rho; mass absorption coefficient, suffix l and s indicate dispersion and particle, respectively. The radiosiotopes, Fe-55, Pu-238 and Cd-109 have high w-values over the wide range of the atomic number. However, a source of high micron value such as Fe-55 is not suitable because the optimal X-ray transmission length, Lopt is decided by the expression, micronlLopt approximately 2/(1+C'ow') by using Cd-109 AgKX-ray source, the weight size distribution of particles from the heavy elements such as PbO2 to light elements such as Al2O3 or flyash was determined.
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