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Biomedical subjects

T Furuse

Publications and source records attributed to T Furuse.

48 records · Page 3Linked to original sources
PubMed1977

Comparative study on radiosensitivities of cultured cell lines derived from several human tumors under hypoxic condition.

Three human cell lines, Burkitt lymphoma cells (P3HR-1), epidermoid carcinoma cells (HeLa S3-1), and melanoma cells (HMV) were irradiated with 200 kV X-rays under three different oxygen conditions. The values of D0 and D10(-2) were estimated for survival curves, and then the dose-modifying factors (DMF) were calculated, for the oxygenated and hypoxic irradiations. These DMF values for oxygenation were not different for each cell line, but those for hypoxia revealed considerable difference for cell lines. From the comparison of modifications due to variable oxygen concentrations on the survival curves of Burkitt lymphoma cells with those of other resistant cells, it is concluded that the shoulder of the survival curves becomes larger primarily with lowering of the oxygen tension, and then D0 value increases followed by a decrease in n value, while in oxygenation, the decrease in D0 value takes place after n value becomes close to 1.

Burkitt Lymphoma↗
PubMed1976

Recovery in Burkitt lymphoma cells after X-ray irradiation.

The radiation response of cultured Burkitt lymphoma cell, known as a particular cell line of high radiosensitivity, was studied by the colony formation method. The values of n, Dq, and Do derived from the survival curve after a single dose X-irradiation resulted in small values as 1.1, 10 rad, and 125 rad. The maximum recovery of about 5% was observed 3 hr after the irradiation by a split-dose experiment. In the survival curve derived from a split-dose irradiation, n and Dq increased while Do remained unchanged. The reason for these increases in n and Dq may be attributed to the nonhomogeneous or mixed population response.

Burkitt Lymphoma↗
PubMed1976

Linear energy transfer-dependent radiosensitivity of Burkitt lymphoma cells, with special references to human melanoma HMV, HeLa-S3, and L5178Y cells.

Dependence of the survival curves of Burkitt lymphoma cells, which were featured by their small n or Dq values, on linear energy transfer (LET) obtained for different quality of radiation was revealed markedly in the change of D0 value, together with a small change in n value. Relative biological effectiveness (RBE) compared with Dq, n and D37 values of Burkitt lymphoma cells for high LET radiation was smaller than that of other cell lines. This finding supports the hypothesis that in Burkitt lymphoma cells the recovery capacity from sublethal damage (Dq) is so small even after low LET irradiation that LET does not modify the suppression of recovery. Similar survival curves with n value closely equal to 1 were obtained for four different mammalian cell lines (Burkitt lymphoma p3HR- 1, human melanoma HMV, HeLa-S3, and L5178Y) after 2 MeV neutron irradiation. This fact may suggest that the radiation which has an LET value at which n value of the survival curve is to be 1 will be optimum for therapeutic purpose to the radioresistant tumors.

Animals↗
PubMedDate not supplied

Characteristics and variability of vertical phoria adaptation in normal adults.

We evaluated the characteristics of phoria adaptation for vertically induced retinal disparity. An adaptive change in the fusion-free ocular alignment, phoria adaptation, was measured with a computer-aided mirror haploscope at 10, 30, and 60 minutes after the start of wearing of a 3-prism-diopter base up prism by 35 normal subjects ranging in age from 21 to 67 years (mean: 37 years). The relationships between phoria adaptation and the subjects' age, the vertical fusional amplitude, the amount of heterophoria, and the starting time of the examination were evaluated. All subjects showed phoria adaptation, with the mean (+/- SD) degree of 0.78 +/- 0.28 degree, 0.96 +/- 0.26 degree and 1.02 +/- 0.30 degrees at 10, 30, and 60 minutes, respectively, after wearing the prism. The repeatability (95% confidence interval) for the measurements was less than +/- 0.24 degree. There was a significant correlation between the vertical fusional amplitude and the gain of phoria adaptation (at 10 and 60 minutes, P < 0.05). The gain of phoria adaptation measured at 60 minutes showed a significant decrease with age (P < 0.01). The results indicate that the time course of phoria adaptation in the vertical direction is similar to that in the horizontal direction and its gain differs considerably among subjects.

Adaptation, Ocular↗