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Biomedical subjects

T Fukuda

Publications and source records attributed to T Fukuda.

At least 1,225 records · Page 68Linked to original sources
PubMed1979

Effects of pentylenetetrazol, pentobarbital and lidocaine on pallidal unit activities in rats.

In anesthetized immobilized rats, pallidal unit activities were recorded extracellularly through glass microelectrodes. Spontaneous activities were converted to an interspike interval histogram and an autocorrelogram by a medical computer and a correlator. Following pentylenetetrazol injection (20 mg/kg i.v.), burst discharges increased remarkably and the bursts tended to synchronize with repetitive spikes in electrocardiogram. Following administration of liocaine (5 mg/kg i.v.) the bursts increased by pentylenetetrazol were facilitated in approximately 70% neurons, whereas pentobarbital showed obvious reduction of the bursts in 80% neurons, although both drugs reduced the firing rate. Facilitation of burst discharges was also observed with high doses of lidocaine alone. These results indicate that lidocaine, as compared with pentobarbital, may block more easily inhibitory rather than excitatory neurons.

Action Potentials↗
PubMed1979

[Epidemiological studies on the symptoms due to strawberry culture in the vinyl-house. 1. An analysis of subjective symptoms by working conditions and constitution of the farmers (author's transl)].

An epidemiological survey focused on farmers engaged in vinyl-house culture of strawberry was carried out among the inhabitants of a farming village. For avoiding residential and habitual factors, all residents (851 in number) over 12 years of age in the area were inquired about symptoms, personal and family histories. There were no marked difference in age and sex among three groups, i.e. farmers with and without vinyl-house culture and people with no relation to farming in this area. Incidence of one of the inquired symptoms were 54% and 45% in farmers with and without strawberry culture in vinyl-house respectively, and 34% in the non-farming people. This difference became more larger up to 83% in the strawberry farmers of allergic constitution. Symptoms found more in the farmers than the other were headache, dizziness, conjunctivitis, rhinorrea, sneeze, palpitation and neuralgia, and the last four symptoms were more marked among farmers in charge of strawberry culture. Incidence of the allergic symptom consisting of conjunctivitis, rhinorrea and sneeze was more marked among the persons of allergic constitution . In conclusion, health effects of strawberry culture in vinyl-house in farmers can be look upon from three aspects; overwork, a particular stance during the work and allergic responses to the dust in the vinyl-house.

Adolescent↗
PubMed1979

[Epidemiological studies on the symptoms due to strawberry culture in the vinyl-house. 2. An analysis of clinical examinations with emphasis on allergic response (author's transl)].

Clinical mass surveys were carried out on the residents to whom questionnaires on symptoms with reference to strawberry culture in the vinyl-house had been delivered. Two hundred and eleven persons attended at the first survey in September, 1976 (off the season of strawberry culture) and the 58 attended at the second survey in March, 1977 (within the season). The participants of the first survey consisted of three groups, i.e. farmers with and without strawberry culture and people without farming. The participants of the second survey consisted only of farmers with strawberry culture. Results are summarized as follows. 1) There were no difference of incidence of various clinical findings detected by an ophthalmologist and otolaryngologists among the three groups. 2) There were also no difference of incidence of abnormal findings in urine tests, liver functions, respiratory test, blood examinations and blood pressure test among the three groups. However, the comparison of persons in charge of strawberry culture and attended at both tof the first and the second surveys, such changes were detected as increases in the value of GOT (within normal limits), of stab neutrophiles, lymphocytes and of monocytes within the season of strawberry culture. 3) Increases of positive rates in skintest by extracts of house dust and Candida sp. were observed in the farmers with and without strawberry culture. Positive rates of skintest by strawberry pollen and honey bee extracts among the farmers with strawberry culture were markedly higher than the allergic patients in Dokkyo Hospital having no relation to this culture. This positive rate was markedly elevated among the persons who complained the symptom of rhinorrea within the season.

Adult↗
PubMed1979

Effect of eye movement on perception of flicker.

With 3 experienced subjects CFF during eye movements was higher than that obtained by fixing a line of sight. CFF increased with a moving line of sight. With additional subjects CFF during eye movements was related to various factors such as target size and conditions of eye movement. More thorough study is required.

Adult↗
PubMed1979

Relation between flicker fusion threshold and retinal positions.

The critical flicker frequencies (CFF) were determined for various locations on the retina. Under the conditions in which pupil size varies little with target luminance and size for a retinal location, two findings were obtained. First, the relation between the CFF value and the retinal location depends basically upon the density distribution of the receptor cells (cones and rods) on the retina. Second, when a large test field is employed, the peripheral area shows a maximal CFF value. These characteristics are explicable in terms of the retinal structure and by assuming some functions for it.

Adaptation, Ocular↗
PubMed1979

[Electrical pacing in the gastroduodenal junction area of conscious dogs (author's transl)].

To determine whether the electric activities of the stomach and duodenum are related, the gastroduodenal junction area of the stomach of dogs was paced through implanted bipolar silver electrodes. It was found that the pacing rate of the basic electrical rhythm (BER) in the antrum of the stomach could be increased to a maximum of 8.9 cycles/min, without affecting the BER frequency in the duodenum. Conversely when the pacing rate of the BER in the duodenum was increased to a maximum of 24 cycles/min, the BER frequency in the antrum remained unaffected. These results show that the BER in the stomach and duodenum are independent, and imply that the BER cycles in the stomach and duodenum are due to the presence of two independent pace-maker areas.

Animals↗
PubMed1979

Effect of aging on the development of gastric cancer in rats induced by N-methyl-N'-nitro-N-nitrosoguanidine.

This experiment was carried out to see the effect of aging on the induction of gastric carcinoma in rats by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Three groups of rats of 3 different ages, 6, 20, and 40 weeks old, were used. Comparison of incidence of gastric carcinoma in these groups revealed a significant difference. Tumor incidence of the gastrointestinal tract of rats were 94.7, 73.8, and 48.8%, resepctively, at 6, 20, and 40 weeks of age. The incidence of adenocarcinomas of glandular stomach was also significantly decreased with the advance in age. However, there was a significant difference in the intake rate of MNNG per gram body weight between the young (6 weeks of age) and old rats for the first 25 weeks during the experiment which may account for the difference in tumor incidence between young and old rats. However, even when the young rats were administered a decreased amount of MNNG, same as that in old rats, they also showed higher incidence. From these results, it was concluded that the amount of MNNG ingested was not responsible for the decreased incidence of gastric adenocarcinoma in older rats. Aging might be the primarily the cause of low incidence.

Adenocarcinoma↗