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Biomedical subjects

T Fukuda

Publications and source records attributed to T Fukuda.

At least 1,081 records · Page 60Linked to original sources
PubMed1984

Acute antihypertensive effect of nifedipine by sublingual route in cases with clinically severe systolic hypertension. A study up to 4 h after administration.

In a multi-center study, nifedipine (Bay a 1040, Adalat) (10 mg capsule) was administered, in liquid form and via sublingual route, to 22 cases who were diagnosed to have clinically severe systolic hypertension, and the depressor effect of the treatment was studied over a period of 4 h. In patients of "emergent" admission (cerebral hemorrhage n = 8, cerebral thrombosis n = 4, subarachnoid hemorrhage n = 1, renal failure n = 6, essential hypertension n = 3), 3 bouts of blood pressure measurement at intervals of 10-15 min during the control period were carried out. In case of systolic blood pressure higher than 200 mmHg, at least one time, nifedipine at a dose of 10 mg was sublingually administered. Thereafter, blood pressure and pulse rate were recorded at intervals of 15 min up to the end of the first one hour, then at intervals of 30 min up to the end of 4 h. Results were as follows. In terms of the average values for all cases, blood pressure fell to near lowest levels by the end of about 30 min after the administration and it stayed at near lowest levels up to the end of 120-240 min. During this period of time, pulse rate remained substantially unchanged. In terms of the pattern of the blood pressure fall, all cases could be classified generally into two types, namely (a) the "dip" group (7 cases) in which blood pressure fell to the lowest level to form a "dip" and remained below the control level, although it showed a trend to return to control level for 4 h and (b) the "flat" group (15 cases) in which blood pressure declined gradually for about 1 h and, then, remained low or below the control level, although it showed a trend to return to control level throughout the rest of the observation period of 4 h.

Administration, Oral↗
PubMed1984

[Effect of nizofenone (Y-9179) on experimental cerebral ischemia in Mongolian gerbils].

The cerebral protective action of nizofenone was compared with that of pentobarbital (PBT) in Mongolian gerbils in which an incomplete circle of Willis causes the development of ischemic damage in the cerebral hemispheres following common carotid arteries occlusion. The mean survival time following occlusion of both common carotid arteries which induced a mortality rate of 100% was 2.3 hr for the control group and 3.3 hr (P less than 0.05) and 4.1 hr (P less than 0.01) for the animals pretreated with nizofenone (10 mg/kg) and PBT (60 mg/kg), respectively. The mortality rate during a 1 month period following transient bilateral occlusion of the carotid arteries for 30 min was 100% for the control group and 41% (P less than 0.01) and 40% (P less than 0.01) for the animals pretreated with nizofenone (30 mg/kg) and PBT (60 mg/kg), respectively. No significant protective action was observed when administration of the drugs was carried out immediately after the onset of recirculation. These results suggest that nizofenone may be an effective cerebral protective agent.

Animals↗
PubMed1984

[Effects of nizofenone on ischemic cerebral edema in Mongolian gerbils].

The effects of nizofenone on ischemic cerebral edema in Mongolian gerbils were compared with those of pentobarbital (PBT). Water content, used as an index of cerebral edema, was calculated from the wet and dry weights of each hemisphere. In the sensitive gerbils subjected to permanent occlusion of the right common carotid artery, water content of the right hemisphere increased by about 6% at 24 hr after ischemia. In the animals treated with nizofenone (30 mg/kg i.p.) and PBT (60 mg/kg i.p.), water content was significantly lower than that of the control group at 24 hr and 1.5-24 hr after ischemia, respectively. In the sensitive gerbils subjected to temporary occlusion of the right common carotid artery for 60 min, water content of the right hemisphere increased gradually by about 5% at 72 hr after recirculation. In the animals treated with nizofenone (30 mg/kg i.p.) and PBT (60 mg/kg i.p.), water content was significantly lower than that of the control group at 24-72 hr and 1.5-72 hr after recirculation, respectively. Nizofenone became effective in lowering brain water content after 24 hr following ischemia. On the other hand, PBT was effective from an early stage of ischemic cerebral edema. Brain edema following an ischemic injury is considered to be initially of the cytotoxic type, subsequently changing into the vasogenic type. The above results suggest that nizofenone may be effective in ameliorating ischemic cerebral edema, particularly vasogenic edema, and that this may be partially related to its cerebral protective action.

Animals↗