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Biomedical subjects

T Fujino

Publications and source records attributed to T Fujino.

At least 379 records · Page 21Linked to original sources
PubMed1980

Entrapment mechanism and ocular injury in orbital blowout fracture.

The entrapment mechanism of the orbital blowout fracture is due to the phase difference of the movement of solid, bony, and elastic, soft orbital structures. The mechanism is enforced secondarily by the increased hydraulic pressure of the orbital contents that results from the orbital and periorbital edema that occurs shortly after the trauma. In addition, according to our concept, the primary causative factor in the mechanism of the orbital blowout fracture is the buckling force, confirmed by our clinical analysis of 101 cases of pure blowout fractures.

Biomechanical Phenomena↗
PubMed1980

Effects of domperidone on serum prolactin levels in human beings.

Effects of domperidone, a dopaminergic antagonist, on serum prolactin levels were studied in 6 normal men and 6 normal cyclic women at the different phases of their menstrual cycles (i.e., the follicular, the preovulatory and the luteal phases). Domperidone (10 mg, i.v.) caused significant increases in serum prolactin in all cases within 15 min after the injection. The prolactin response was significantly (p < 0.01) higher in women than in men, and there was no significant difference in the prolactin responses among the three phases of the menstrual cycles. These results indicate that domperidone may be an effective stimulator of serum prolactin secretion in human beings.

Adult↗
PubMed1980

Antagonistic action of alpha- and beta-agonists on the bullfrog atrium.

Action of alpha- and beta-agonists on the membrane potential, current and tension components on the bullfrog atrial muscle were studied by means of the single or double sucrose-gap technique. Isoproterenol (10(-9)-10(-5) M) as well as adrenaline (10(-7)-10(-4) M) produced a dose-dependent positive inotropic effect, while methoxamine (10(-8)-10(-4) M) and phenylephrine (10(-8)-10(-3) M) with propranolol (10(-6) M) elicited a negative inotropic effect. The positive inotropic effect was accompanied by slight hyperpolarization and marked increase of over-shoot and plateau level of action potential, and the negative inotropic effect, by opposite changes. Under voltage clamp, isoproterenol and adrenaline produced enhancement of slow inward current (Is), delayed outward current (Ix) and Is-dependent phasic tension, while Is-independent tonic tension was inhibited. Contrarily, methoxamine and phenylephrine depressed these currents and elicited beta-antagonistic inotropic actions, especially when isoproterenol was present. Specific feature of alpha-agonist action in the presence of isoproterenol was an inward shift of the semi-steady I-V relationship. It is thus suggested that, in the bullfrog atrium, alpha-agonists produce a strong beta-receptor blocking action and an inward shift of the background current. A possible relationship between the latter effect and inhibition of the Na-K pump is also suggested.

Action Potentials↗
PubMed1979

Tumor antigen of human cervical squamous cell carcinoma: correlation of circulating levels with disease progress.

A double-antibody radioimmunoassay method was used for serial determinations of a tumor-antigen (TA-4) of cervical squamous cell carcinoma, and the correlation of serum antigen levels with the disease progess was investigated in 23 patients with cervical squamous cell carcinoma. Ten cases with widespread metastases received radiotherapy and/or chemotherapy. Nine of these cases who showed progression of the disease had a corresponding increase in serum antigen levels, while one case who had regression of the disease showed a corresponding decrease in serum antigen levels. Thirteen patients received radical surgery, and in all of these, high pretreatment antigen levels declined to undetectable levels 1 or 2 weeks after surgery. A panel of coded sera from the NCI-Mayo Clinic Serum Bank was also studied for evaluating the specificity of the assay. Thirteen of 25 patients (52%) with cervical squamous cell carcinoma showed positive serum antigen levels, while only one of 58 control cases (1.7%) showed false-positive result. These results suggest that serial TA-4 determinations may provide a useful method for evaluating regression or progression of the disease.

Adult↗
PubMed1979

The ultrastructural characterization of the tegument of Clonorchis sinensis (Cobbold, 1875) cercaria.

The tegumental ultrastructure of the cercaria of the liver fluke, Clonorchis sinensis (Cobbold, 1875), was studied by scanning and transmission electron microscopy. The body surface is almost encircled by many rows of regularly arranged spines. The tegumental syncytium of the body contains many rod-shaped dense granules and central electron-lucent bodies, neither of which are present in the tail tegument. There are four rows of hooked teeth and modified spines on the oral cone. These teeth are differentiated morphologically and probably functionally from the other body spines. Disc-shaped papillae with long or short cilia are distributed on the body in a bilaterally symmetrical pattern dorsally and ventrally. There are 30 to 37 papillae with much longer cilia laterally. Four pairs of papillae were found on the tail. From their structure and location these papillae appear to have a mainly tango- or rheoreceptive function. Another type of sheathed papillae is situated around the oral sucker. The cuticular tegument is expanded laterally at the base of the tail, forming a characteristic sac-like structure.

Animals↗
PubMed1979

Mutagens in Japanese pickle identified as flavonoids.

A kind of Japanese pickel was mutagenic to TA100 and TA98 with S9 mix. Its activity was one sixth that of the Chinese pickle from Linhsien County (China), reported previously. Mutagens in this Japanese pickle were isolated; the main component was identified as kaempferol, and a minor component as isorhamnetin. Flavonoids are ubiquitous and the principles identified, kaempferol and isorhamnetin, do not seem to be specific to the pickle vegetable, implying that the mutagenic substances responsible for the high incidence of human cancer in China remain to be identified.

Drug Evaluation, Preclinical↗
PubMed1979

Surface ultrastructure of the tegument of Clonorchis sinensis newly excysted juveniles and adult worms.

The tegumental structures of newly excysted juveniles and adult worms of Clonorchis sinensis were studied using scanning and transmission electron microscopy. After excystation the juvenile's tegumental surface is characterized by knoblike protuberances and is armed almost entirely with numerous rows of small spines encircling the body. These spines are double- or triple-pointed on the anterior portion of the body and become single-pointed posteriorly. Four types of presumed sensory structures were observed as follow: A) ciliated knoblike papillae and B) nonciliated platelike papillae, both of which are arranged in rougly a bilaterally symmetrical pattern dorsally, ventrally, and laterally; C) rounded swellings of nonciliated papillae on the lips of the ventral and oral suckers, which are characterized in the transmission electron microscope by a rounded dense body in the apical bulb; and D) a sensory receptor with a bulbous projection having the appearance of a modified cilium, which was not found with SEM likely owing to its being enclosed by an extension of the tegument. In full-grown adult worms, the tegumental surface is knobbed or lobulated in various forms without surface spines. The tegumental structures in the adults appear to be clearly differentiated from those in the juveniles. Upraised, buttonlike papillae, each topped by a short cilium, which are similar to the Type A papillae in the juveniles, are distributed thickly around the oral and ventral suckers, and are rather randomly scattered over the remainder of the body. Some nonciliated swollen papillae were found on the lip of the ventral sucker.

Aging↗