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Biomedical subjects

T Fujimoto

Publications and source records attributed to T Fujimoto.

At least 811 records · Page 45Linked to original sources
PubMed1977

The origin, migration and fine morphology of human primordial germ cells.

Human primordial germ cells (PGCs) were observed ultrastructurally in stages from their endodermal to gonadal locations. Primitive PGCs in the hind-gut epithelium of the 4-week embryo, were recognized as well demarcated cells from the neighboring cells. At the time fo separation, the basal lamina of the epithelium was broken, then, through the gap so opened, the PGCs started to escape into the outer mesenchyme. In embryos at five weeks, PGCs were in the migration stage, and were found in the dorsal mesentery, at the coelomic angle and in the forming germinal ridge. In embryos at six weeks or later, almost all PGCS were accumulated in the gonad. The PGC was characterized by its large size and the large and round nucleus with conspicuous nucleolus, and by the presence of abundant glycogen particles and a considerable number of lipid droplets in the cytoplasm. Alkaline phosphatase activity was demonstrated selectively on the plasma membrane of the PGC. The shape of PGC was irregular, often had pseudopodia in PGCs in the separation and migration stages, suggesting their amoeboid movement in vivo, but was generally round or elliptic in PGCs in the settlement stage. The PGC was usually surrounded by and in close association with adjacent somatic cells.

Age Factors↗
PubMed1977

Pathology of lupus nephritis with special reference to the immunological bases of glomerular changes.

Glomerular changes, and cellular and tissue responses of antibody-forming organs in 37 cases (20 cases with nephrotic syndrome and 17 cases without the syndrome) of systemic lupus erythematosus (SLE) were described. The glomerular changes were classified into 3 types, i.e., proliferative glomerulitis, membranous transformation, and wire-loop lesion from the standpoint of glomerular functional structure and its alterations. As to the responses of antibody-forming organs, hypoplasia of myeloid tissue, atrophy of lymph follicles of spleen and lymph nodes, atrophy and decrease in numbers of lymphocytes of thymus, proliferation and infiltration of plasma cells and plasmocytoid basophilic mononuclears, and proliferation of basophilic reticulum cells at the cost of differentiated antibody-forming organ tissues of bone marrow, spleen, lymph nodes, etc. were noted. Immunological bases of glomerular changes were considered and discussed in the light of pathological findings of SLE presented here and suggestions from experimental pathological studies in this field. Pathogenic roles of antigen-antibody complexes as well as anti-glomerular basement membrane (anti-GBM) antibody were considered in relation to the histologic manifestations of glomeruli in SLE or lupus nephritis.

Adolescent↗
PubMed1977

[Indirect measurement of intracranial pressure, with special reference to its principles and experiments with animals].

A new technique for measurement of intracranial pressure was presented. By using this method a) absolute value of pressure, b) easy, simple and inexpensive long-term measurement and c) decrease in danger of infection are obtained. The apparatus consists of an external device which converts displacement of its membrane into quantitative change of beam and an internal chamber with two membranes that is implanted in a burr hole between scalp and dura mater. These devices have the same diameter and no direct connection each other. When a pressure in the external device is varied, a pressure-displacement curve of its membrane is resulted. The pressure of the external device at the point of inflexion of the curve is representative of the pressure in the internal chamber. In the animal experiment, satisfactory results were obtained.

Animals↗
PubMed1977

Effect of diltiazem on coronary blood flow of the heart with experimental coronary sclerosis and on regional myocardial blood flow of the heart with acute myocardial ischemia.

Effects of 3-acetoxy-2,3-dihydro-5[2-(dimethyl-amino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4 (5H)-one hydrochloride (diltiazem) on coronary circulation of the heart with experimental coronary sclerosis induced by i.v. allylamine (Group A), and on regional myocardial blood flow in acutely-induced ischemic myocardium (Group S) were studied in anesthetized open-chest dogs. Regional myocardial blood flow was continuously measured with heated cross thermocouple method and following results were obtained: 1. In Group A coronary blood flow and coronary flow resistance remained unchanged essentially after the injection of diltiazem, whereas coronary blood flow markedly rose and coronary flow resistance decreased in the normal heart. 2. Local blood flow in both of the inner and outer thirds of the ischemic myocardium was not affected by diltiazem in Group S. In the normal myocardium, however, it increased definitely. 3. From these findings it is concluded that the clinical effectiveness of diltiazem is independent of its vasodilator properties.

Acute Disease↗