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Biomedical subjects

T Fuchs

Publications and source records attributed to T Fuchs.

At least 127 records · Page 7Linked to original sources
PubMed1987

Application of the first international standard of Dermatophagoides pteronyssinus (house dust mite) in the evaluation of allergen extracts produced from two different source materials.

The first international standard (IS) of the house dust mite Dermatophagoides pteronyssinus was used to compare side-by-side two allergen extracts prepared from two different house dust mite sources, namely whole mite cultures (WMC) and purified mite bodies (PMB), by employing several biochemical and immunochemical methods. In most methods employed, IS and WMC resembled more to each other than to PMB. These similarities comprehend protein contents, protein patterns, antigen and allergen patterns as well as total in vitro activity obtained in RAST inhibition (RI). The differences between WMC and PMB could be reproduced in different batches. Standardization in relation to IS of D. pteronyssinus yields activity ratios ranging from 2.4 to 70.1 between WMC and PMB depending on the variation of RI employed, indicating quantitative differences between the two preparations. When coupled to BrCN activated paper disks and employed in direct RAST, both preparations yielded almost identical binding values of specific IgE. Also in skin prick test, WMC and PMB produced very similar results in 12 mite-allergic patients. It was not possible to differentiate between the two preparations when used in concentrations which are usually employed for diagnostic purposes. These findings demonstrate the diversity of allergens in mite extracts derived from different sources and reveal the problems which are involved with the use of the WHO D. pteronyssinus IS.

Allergens↗
PubMed1987

A prospective study of Chlamydia trachomatis infection following legal abortion.

In a prospective study, 288 women were tested for Chlamydia trachomatis (CT) in the cervix prior to legal abortion. In the control group (n = 259), CT culturing was carried out only when postoperative infection was suspected. CT was isolated in 14.2% of asymptomatic women. These patients were treated preoperatively with Doxycycline. In this group, no cases of postoperative infection were detected. Among those cases where CT was not detected, 4.9% contracted the infection, while in the control group the rate of infection was 9.7%. In the control group all the infections due to CT gave late symptoms after the operation (1-4 weeks).

Abortion, Induced↗
PubMed1984

[Dirt tattooing following an explosion in a chemistry class].

Traumatic tattooing following an explosion can generally be removed by rubbing with a hard-bristle handbrush within 48 h after the accident occurs. This measure failed, however, in the case of a pupil with extensively dispersed granular material in the face. The patient had mixed approximately 5 g of potassium permanganate and red phosphorus together during a chemistry lesson (!), thereby causing an explosion. A conservative treatment of applying compresses moistened with a sodium bicarbonate solution led to healing without scars.

Adolescent↗
PubMed1983

The A-rod--a new possibility for cervical dilation and/or induction of uterine contractions for abortion or delivery by combined pharmacological and mechanical action.

A hydrogel compound (Sauflex, Special Polymers Ltd., London) which has the capacity to swell by absorbing surrounding fluid, was found to be capable of absorbing prostaglandins (PGE1, PGF2 alpha) in alcohol or saline during this process. After evaporation of the hydratized hydrogelic compound which restored its initial proportions and stiffness, rehydratization of the hydrogelic compound caused it to release the respective prostaglandin to the surrounding medium or tissues. The endocervical canal of first-trimester abortions was dilated by plain mechanical action of a rod-shaped hydrogel body (A-rod) inserted in the cervical canal. By loading the A-rod with PGF2 alpha (2-110 mg) the cervical canal was additionally widened and abortive contractions were elicited in the uterus. Further implications of the medical use of the A-rod are discussed.

Abortion, Induced↗
PubMed1983

Human leukocyte antigens group A in couples with unexplained infertility.

The human leukocyte antigen (HLA) frequencies and antigen sharing were studied in 14 couples with unexplained infertility. There were no significant differences in the frequency of HLA-A, B, C, or DR antigens, as compared with normal control subjects. Furthermore, the degree of HLA sharing did not deviate from that theoretically expected. An increased frequency of HLA-DR sharing, as compared with the expected frequency, was observed in a control group consisting of parents of children with leukemia. When infertile spouses were tested for mixed lymphocyte culture reactivity, there were no indications of an altered reactivity, as compared with control subjects.

Female↗
PubMed1982

[Clinical importance of sampling method in leucocyturia (author's transl)].

The clinical importance of the method of obtaining a urine sample (spontaneous vs. catheter and midstream specimens) was investigated in 507 in-patients. Whereas leucocyturia was demonstrated with the Cytur-Test on spontaneous urine from 105 patients, only 30 out of 89 of these patients showed leucocyturia in catheter or midstream specimens one to three days later. All 30 positive cases were found to have a disease state which causes leucocyturia. A direct comparison between spontaneous urine and midstream or catheter urine taken at the same time in 68 patients showed a leucocyturia in 20 cases in spontaneous urine which could not be confirmed in the midstream or catheter urine. This drastic difference shows the importance of the method of obtaining specimens in estimating leucocyturia.

Diagnostic Errors↗
PubMed1982

Sex-dependent induction of human suppressor T cells by chorionic gonadotropin.

Human chorionic gonadotropin (hCG) in physiological retroplacental concentration has been shown to induce human female lymphocytes which suppress the proliferation and differentiation of B cells stimulated by purified protein derivative of tuberculin. To test whether the hCG-induced suppression was sex dependent parallel experiments using female and male peripheral lymphocytes were performed. hCG did not induce cells capable of suppressing purified protein derivative induced B cell proliferation in lymphocytes from males, which was in contrast to lymphocytes from females where a statistically significant suppression was found. A similar hCG-induced suppressive effect was found before menarche, after the menopause and in two patients with Turner's syndrome, suggesting that a gene(s) on the Y chromosome exerts a regulatory function and thus prevents the hormone from inducing suppressor T cells.

Aging↗
PubMed1981

In vitro induction of human suppressor T cells by a chorionic gonadotropin preparation.

Human chorionic gonadotropin (hCG) in physiological retroplacental concentration has been shown to possess the capacity of inducing human lymphocytes which are subsequently competent to depress an antibody response induced by purified protein derivative of tuberculin, phytohemagglutinin, lipopolysaccharide and pokeweed mitogen. These suppressor cells inhibited the T cell-dependent mitogen-induced activation of lymphocytes synthesizing IgM, IgG and IgA. No suppression by hCG-induced cells was observed in Epstein-Barr virus activated cell cultures, indicating a T cell origin of the target cell. It is suggested that this may represent a mechanism for the cellular basis of an hCG-induced immunosuppressive effect in pregnancy.

Adult↗
PubMed1980

In vitro induction of murine suppressor T-cells by human chorionic gonadotropin.

Human chorionic gonadotropin (HCG) has previously been considered to be immunosuppressive and, thus, by prohibiting maternal rejection of the fetal transplant, to be one of the factors responsible for the successful outcome of pregnancy. The mechanism by which HCG exerts its pregnancy retaining effect is, however, as yet unknown. The present study shows that HCG has the capacity in mice of inducing lymphocytes which are subsequently competent to depress a polyclonal antibody response induced by different B cell mitogens. It is therefore suggested that HCG may exert its feto-protective action by inducing suppressor T cells. These lymphocytes would thus prevent the activation of cells which are responsible for transplant rejection.

Animals↗
PubMed1980

[Surgery of carpal tunnel syndrome without interfascicular neurolysis].

198 operations of carpal tunnel syndrome demonstrated that the simple dissection of the ligamentum carpi transversum is followed by excellent results. One year after the operation among the hands with thenar muscle atrophy 82% returned to normal and 11% were improved. Among the cases with preoperative complete loss of function (axonotmesis) of the power grade 5 postoperatively. The capacity for regeneration is not different between the motor and the sensory fibers of the nerve. The restoration of the muscle power depends on the grade of the muscle fibrosis after long denervation. The comparison with the results of other authors demonstrates no advantage of the additional interfascicular neurolysis.

Carpal Tunnel Syndrome↗