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Biomedical subjects

T Friis

Publications and source records attributed to T Friis.

At least 91 records · Page 5Linked to original sources
PubMed1975

Treatment of osteoporosis of ageing with 1alpha-hydroxycholecalciferol.

Seven patients with osteoporosis of ageing were treated with synthetic 1alpha-hydroxycholecalciferol (1alpha-H.C.C.) for 3-4 months. The compound was given at a daily oral dose of 2 mug together with an oral supplement of 1 g of calcium. Clinically there was a striking improvement in the patients' physical fitness. Increased bone formation and mineralisation were seen on iliac-crest bone biopsy, and this was supported by an increased osteoblastic activity demonstrated by histochemical measurement of alkaline-phosphatase activity. Bone histology furthermore showed a reduced bone resorption, which was supported by a reduced urinary excretion of total hydroxyproline. Photon absorptiometry of the forearm accorded with the histological findings, showing a significant increase in the bone mineral content. Serum-calcium rose in all patients, one developing a severe transitory hypercalcaemia. The urinary excretion of calcium and magnesium increased significantly. The serum concentrations of 25-hydroxycholecalciferol and parathyroid hormone were not significantly affected by the treatment. It is concluded that 1alpha-H.C.C. is an effective tool in the treatment of senile osteoporosis.

Administration, Oral↗
PubMed1975

Stimulation with thyrotrophin-releasing hormone (TRH) during antithyroid treatment.

During antithyroid treatment a total of 88 TRH tests was performed in 56 clinical euthyroid patients. 56% had negative response to TRH (i.e. delta TSH smaller than 2 muU/ml) after being treated in average 12.6 months and no relation between the duration of treatment and the outcome of the TRH test was found. In the group with positive TRH tests (i.e. delta TSH greater than 2 muU/ml) the mean T4 value was slightly decreased (5.8 plus or minus SD 2.5 mug/100 ml) while the mean T3 value was normal (121 plus or minus SD 32 ng/100 ml). The group with negative TRH tests had quite normal serum T4 values (9.3 plus or minus SD 3.1 mug/100 ml) but in general high normal or elevated serum T3 values (175 plus or minus SD 31 ng/100 ml). Our results seem to indicate that serum T3 is of greater importance than serum T4 with regard to the outcome of the TRH test. The majority of the cases with negative TRH tests, however, had serum T3 and T4 values within normal range. In almost all patients with a negative TRH test a negative T3 suppression of 131I uptake in the thyroid gland was found while a positive TRH test was not correlated with suppressibility of 131I uptake.

Adult↗
PubMed1975

Fine needle and open biopsy in thyroid disorders.

The diagnostic value of cytological, serological and scintigraphical examination was evaluated in 20 histologically verified cases of thyroid disorder. The predictive values of specificity as to malignancy, thyroiditis and thyroid autoantibodies were respectively 0 percent (0-71), 80 percent (28-99) and 75 percent (19-99), and the predictive values of sensitivity were 88 percent (64-99), 100 percent (78-100) and 94 percent (70-100). Cold nodules were malignant in 40 percent. Fine needle biopsy can be used as a supplementary test without any risks and is a valuable aid in the diagnosis of Hashimoto's thyroiditis, but not in the diagnosis of malignant lesions. If any clinical or scintigraphical (cold nodule) suspicion of malignancy exists, a surgical biopsy must be done.

Adult↗
PubMed1975

Normal response to thyrotrophin releasing hormone (TRH) in familial thyroxine-binding globulin deficiency.

The response in serum thyrotrophin (TSH) to thyrotrophin releasing hormone (TRH) has been studied in 5 euthyroid patients with familial thyroxine-binding globulin (TBG) deficiency. Total serum thyroxine (T4), serum triiodothyronine (T3) and free T4 index and free T3 index were significantly and equally decreased, but in spite of these findings the serum TSH and response to TRH was normal. The TRH test seems to be a better indicator of the euthyroid state in familial TBG deficiency than the measurement of free T4 and free T3 in serum.

Adult↗