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Biomedical subjects

T Frank

Publications and source records attributed to T Frank.

At least 73 records · Page 4Linked to original sources
PubMed1987

Accuracy of a 40 dB HL Audioscope and audiometer screening for adults.

This study determined the accuracy of an AudioScope (AS) and pure-tone audiometer (PTA) screening at 40 dB HL from 500 to 4000 Hz in reference to a pure-tone threshold (PTT) test on 1210 ears of adult subjects 20 to 96 yr old. The overall results (averaged over age group and frequency) indicated that the AS and PTA screenings were equally accurate in reference to the PTT test. Averaged over the screening tests, the sensitivity was 91.4% with a false negative rate of 8.6% and the specificity was 93.5% with a false positive rate of 6.5%. As a function of age (averaged over frequency), the AS and PTA screenings had similar accuracy and decreased as age increased to about 60 yr old and then remained stable. As a function of frequency (averaged over age), each screening test had similar accuracy for each frequency. It was concluded that the results of a 40 dB HL AS or PTA screening are very accurate in reference to a PTT test.

Adult↗
PubMed1987

Repeatability of high-frequency bone conduction thresholds.

The purpose of this study was to determine the repeatability of high-frequency, bone conduction thresholds and to increase the data base concerning high-frequency, bone conduction threshold levels. Bone conduction thresholds were obtained on 30 subjects having normal, low, and mid frequency (0.25 to 8 kHz) hearing thresholds within and across five test sessions using a Pracitronic KH 70 bone vibrator referenced to a Brüel and Kjaer 4930 mechanical coupler at 1, 4, 8, 10, 12, 14, and 16 kHz. Within and across sessions, the bone conduction thresholds were not significantly (p greater than 0.05) different at each frequency indicating that repeated testing without replacing the bone vibrator (within session) and with replacing the bone vibrator (across session) did not influence the threshold measurements. Clinical implications concerning high-frequency, bone conduction audiometry are discussed.

Adult↗
PubMed1986

Random-clone strategy for genomic restriction mapping in yeast.

An approach to global restriction mapping is described that is applicable to any complex source DNA. By analyzing a single restriction digest for each member of a redundant set of lambda clones, a data base is constructed that contains fragment-size lists for all the clones. The clones are then grouped into subsets, each member of which is related to at least one other member by a significant overlap. Finally, a tree-searching algorithm seeks restriction maps that are consistent with the fragment-size lists for all the clones in each subset. The feasibility of the approach has been demonstrated by collecting data on 5000 lambda clones containing random 15-kilobase inserts of yeast DNA. It is shown that these data can be analyzed to produce regional maps of the yeast genome, extending in some cases for over 100 kilobases. In combination with hybridization probes to previously cloned genes, these local maps are already useful for defining the physical arrangement of closely linked genes. They may in the future serve as building blocks for the construction of a continuous global map.

Chromosome Mapping↗
PubMed1986

Coupler output level differences resulting from repeated transducer placement.

Coupler output levels were obtained for six repeated placements of a TDH-49 earphone in a P/N 51 cushion on a NBS 9A coupler and a B-71 and B-72 bone vibrator on a mechanical coupler from 250 to 4000 Hz using experienced (N = 9) and untrained subjects (N = 9) who were later trained. The largest minus the smallest coupler output levels across the repeated placements were determined for each subject and transducer at each frequency. The coupler output level differences were similar across subject group for each transducer at each frequency and were not reduced by training. The median and mean differences for the TDH-49 were less than 1 dB, consistent across frequency, and the highest range score never exceeded ANSI tolerance levels. The median and mean differences for the B-71 and B-72 were higher than for the TDH-49 but did not exceed ANSI tolerance levels and were frequency dependent corresponding to the high frequency resonance slope of the vibrator. However, for some subjects, the differences exceeded ANSI tolerance levels for both vibrators, especially for the B-72 at 250, 2000, and 4000 Hz.

Audiometry↗
PubMed1986

Acoustic radiation produced by B-71, B-72, and KH 70 bone vibrators.

The amount of acoustic radiation produced by two samples of a Radioear B-71, B-72, and Pracitronic KH 70 bone vibrator was determined for 30 normal-hearing subjects at 4000 Hz. The mean amount of acoustic radiation was very similar for both samples of each vibrator type but significantly (p less than 0.05) different between the bone vibrator types. The mean amount of acoustic radiation averaged over both samples was 8.3 dB for the B-72, 4.3 dB for the B-71, and -0.3 dB for the KH 70. Individual subject data indicated that the B-72 produced excessive acoustic radiation (greater than 5 dB) for 80% of the subjects, the B-71 for 38% of the subjects, and the KH 70 for 8% of the subjects which could cause an invalid high-frequency air-bone gap. Precautions should be taken during bone conduction audiometry to eliminate the possibility of acoustic radiation produced by bone vibrators. A need for additional standards in this area is stressed.

Acoustics↗
PubMed1984

Comparison of the Auditec and Rintelmann recordings of the NU-6.

Word discrimination scores were obtained for 30 normally hearing listeners using Auditec and Rintelmann recordings of the NU-6 presented at 60 and 70 dB SPL in quiet and in a background of multitalker noise at signal-to-noise (S/N) ratios of +12, +6, 0, and -6 dB. This was done to obtain normative data and to determine whether these two recordings of the same word lists were equivalent at conversational levels in quiet and in a noisy background. The word discrimination scores for each recording in quiet and at each S/N ratio were not significantly different when presented at 60 and 70 dB SPL. However, the word discrimination scores were significantly poorer as the S/N ratio became more severe, and the scores obtained with the Auditec recording were significantly poorer than those obtained with the Rintelmann recording at each S/N ratio. These differences between word discrimination scores using the Auditec and Rintelmann recordings were primarily attributed to the recorded level of the test word and secondarily attributed to carrier phrase and talker differences.

Adult↗
PubMed1984

[Venous digital subtraction arteriography of the pelvic and leg area with step displacement].

By combining a 40 cm image amplifier, a DSA equipment, and the technique of step displacement, it became possible to demonstrate transvenously the arterial flow, beginning with the descent of the tibia, in four stages, using only two series of examinations. Venous digital subtraction arteriography of the pelvis/leg region was performed in 140 patients. The results were compared partly with arterial digital and analogue arteriographies as well as with surgical findings.

Angiography↗
PubMed1984

Single photon emission computerized tomography (SPECT) for estimates of liver and spleen volume.

A simple procedure is described for estimates of liver and spleen volume using the imaging data obtained during single photon emission computerized tomography ( SPECT ). In vitro studies were carried out to obtain correlation and regression coefficients for volume estimations. Using these regression coefficients, we estimated liver and spleen volumes in 50 patients. Phantom and organ volumes were also calculated from transmission computed tomography (TCT), whose results served as the reference procedure against which SPECT -determined volumes were compared. The influence of radiotracer uptake on scintigraphic volume predictions was also assessed. For the in vitro measurements, SPECT volumes predicted the true volumes with a coefficient of correlation of 0.997. When in vivo SPECT volumes were correlated with those obtained by TCT, a coefficient in excess of 0.9 was achieved. SPECT volume determinations proved to be influenced by organ uptake of tracer; high liver uptake and low spleen-to-liver ratios gave the best results. It is concluded that SPECT imaging offers access to rapid and exact volume estimation.

Humans↗
PubMed1983

Phagocytosis in the uterus: A review.

Phagocytosis is an important non-specific defense mechanism. Uterine phagocytosis is reviewed emphasizing factors which may alter the uterine phagocytic responses including the estrous cycle, pregnancy and the puerperium, and the presence of an intrauterine device. Implications of phagocytosis in therapy of and recovery from intrauterine infections are considered.

Journal Article↗
PubMed1983

Air-bone gap distributions in normal-hearing subjects.

Unmasked (UM) and masked (M) AC and BC thresholds were obtained on 48 normal-hearing young adults. The UMAC and MBC thresholds were in agreement with standardized reference levels. The mean air-bone gaps (A-B G's) were less than 1 db for the three comparisons (UMAC minus UMBC; UMAC minus MBC; MAC minus MBC). The distribution of the individual Ss' A-B G's for each AC minus BC threshold comparison resembled a slightly flattened normal curve showing that some Ss had a positive while some had a negative A-B G. Over the 3 comparisons per S, 34% of the Ss exhibited negligible A-B G's of +/- 2.5 db, while 17.4% exhibited A-B G's greater than or equal to 7.5 db. The common rule that Ss with a normal conductive hearing mechanism have an A-B G of 0 db can only be used for mean data and not be applied to individual Ss tested in clinical practice or used for subjective BC calibration.

Adolescent↗
PubMed1980

[Ultrasound in the diagnosis of thyroid disease (author's transl)].

The article reports on the technique of examination, on echo patterns and their pathomorphological classification, incorporation of sonography in the pattern of thyroid diagnosis based on nuclear medicine, differential diagnosis of echo patterns, and significance of sonography.

Diagnosis, Differential↗