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Biomedical subjects

T Fekete

Publications and source records attributed to T Fekete.

78 records · Page 5Linked to original sources
PubMedDate not supplied

Microalbuminuria, as predictor of late diabetic complications. A prospective study.

To assess the predictive value of microalbuminuria (M) for diabetic macro- and microangiopathy, neuropathy and some related risk factors studies were carried out in 105 diabetic subjects. All examinations were repeated after one year. Microalbuminuria was found to parallel all late diabetic complications, at the beginning of investigations and also after a one-year evolution. It also positively correlated with some risk factors for angiopathy, such as plasma lipid parameters, blood pressure, body mass index and duration of disease.

Adolescent↗
PubMedDate not supplied

Vascular risk factors in the obliterative peripheral arteriopathy of diabetic patients.

To estimate the role of some vascular risk factors in the obliterative arteriopathy of diabetic patients, 71 subjects have been investigated: diabetics without arteriopathy, diabetics with arteriopathy and non-diabetics with arteriopathy. Age, sex, body weight, smoking habits, blood pressure, sedentary life style, diabetes therapy, plasma glucose, cholesterol, triglycerides, total lipids, HDL-cholesterol, uric acid, and fibrinogen have been assessed, the parameters investigated. The results show that the risk factors studied maintain their role even in the obliterative peripheral arteriopathy of diabetic patients; however, there are differences in the relative importance of some of them.

Age Factors↗
PubMedDate not supplied

Fibrinolysis in diabetes mellitus. Role of overweight and hypertriglyceridemia.

The variations of dilute blood clot lysis time (DBCLT) in 103 diabetic patients were investigated in terms of insulin dependency, body weight, serum lipids and presence of diabetic vascular diseases. The results showed that DBCLT was significantly longer in the 34 overweight diabetic patients (437 +/- 68 min) than in the 69 diabetics at or below the ideal body weight (240 +/- 28 min) or in the 76 normalipidemic normal weight control subjects (253 +/- 12 min). DBCLT was also longer in the hypertrigliceridemic diabetic patients than in the normolipidemic ones. The mean lysis time was similar in diabetic patients with and without retinopathy. However, a higher level of fibrinolytic inhibitors was found in patients with diabetic small vessel disease. In vitro inhibition of plasma factor XIII by p-chlormercuribenzoate (PCMB) caused an acceleration of DBCLT and the differences between lysis time in the overweight diabetics and in the controls were attenuated. These results suggested that deficient thrombolysis is rather due to overweight and to disturbances of lipid metabolism than to diabets and/or its vascular complications and that enhanced fibrin crosslinking is at least partially responsible for delayed clot lysis.

Adolescent↗
PubMedDate not supplied

Arterial hypertension in diabetic patients. Role of obesity.

In order to assess the role of obesity and to correlate it with other possible factors which cause the well-known higher prevalence of arterial hypertension in diabetic patients without nephropathy, 829 non-proteinuric diabetic outpatients and 856 controls have been investigated. A significantly higher prevalence of arterial hypertension was found in obese patients than in normal-weight subjects. Likewise, hypertensive diabetic patients were more frequently obese than those with normal blood pressure. Arterial hypertension was more often encountered in female diabetics, since women were more obese. The duration of diabetes and age-related increase of arterial hypertension was augmented by the presence of obesity. The practical implications of the observations are emphasized.

Adult↗
PubMedDate not supplied

Serum pseudocholinesterase activity during experimental fattening.

The exact role of serum pseudocholinesterase (PSCE) is not known. Its main role probably consists in the degradation of butyril-choline, an intermediate of lipid metabolism. Decreased values have been described in liver cirrhosis as an index of diminished proteosynthetic function. An increased activity of this enzyme was reported in obesity, diabetes mellitus, nephrosis, hyperthyroidism and in hyperlipemic subjects without obesity. A significant correlation was found between serum cholesterol, triglycerides and PSCE, as an expression of lipid metabolism. In view of assessing the possible change of this enzyme during fattening, the authors investigated PSCE activity during fattening in pigs (the same breed). The results indicate a statistically significant increase of PSCE during fattening, from 30.4 +/- 1.7 to 43.6 +/- 1.7 (p less than 0.001). These results together with those reported in a previous paper concerning blood lipids and cholesterol, show a positive correlation between these parameters and PSCE during fattening in pigs, which might be due to an adaptative increase of the hepatic synthesis of this enzyme in response to the increased lipid metabolism.

Age Factors↗