Torsade de pointes ventricular tachycardia associated with lidoflazine therapy.
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Biomedical subjects
Publications and source records attributed to T Fazekas.
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The case history of a mother and daughter with familial periodic paralysis serves to illustrate the features of the hypokalaemic form of this condition. The development of attacks in the child does not appear to be based on intermittent hyperaldosteronism as trigger mechanism. A good therapeutic response to the potassium-retaining preparation, triamterene is reported.
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In this case report, a congestive cardiomyopathy caused by long-term organic phosphoric acid ester exposure is described. The cardiotoxicity and the role of such poisons in the genesis of cardiomyopathy are also discussed.
168 cases of organophosphate poisonings are reviewed with special respect to frequent arrhythmias. In 134 cases toxic repolarisation with QT prolongation, ST- and T- anomalies were present. 56 patients had arrhythmias and the prevalence of ventricular arrhythmias was impressive. In five patients a transient picture of myocardial infarction was seen. The great incidence of ECG alterations and arrhythmias necessitate the permanent monitoring of patients with organophosphate poisoning in an intensive care unit.
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Authors have reported ECG signs of pulmonary embolism caused by lymphography injected contrast oil. Signs indicative of transitory right ventricular strain were observed in the ECG in 17 of 30 clinically symptom-free patients.
A case is reported of ventricular extrasystole occurring during Lidoflazin treatment. It is considered that Lidoflazin is an effective pharmacon, but that it may enhance the ventricular irritability. Attention is drawn to the necessity of the frequent control of Lidoflazin-treated patients.