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Biomedical subjects

T Fanning

Publications and source records attributed to T Fanning.

24 records · Page 2Linked to original sources
PubMed1990

Fine-needle aspiration cytology and flow cytometry of intracystic papillary carcinoma of breast.

To define criteria for cytologic diagnosis of intracystic papillary carcinoma (ICPC), the authors retrospectively reviewed the fine-needle aspiration (FNA) cytologic specimens of eight cases of histologically proven ICPC of breast. The patients were five black and three white women, 56-87 years of age. The FNA specimen was cyst fluid in four cases (bloody in three, clear in one). All the aspirates showed cellular smears with small and large clusters of cells with papillary and/or cribriform configurations and numerous single epithelial cells. The cells were cuboidal to columnar with minimal atypia. ICPC was suggested by FNA in each case, and all the patients underwent surgical excision or mastectomy. Flow cytometry, performed on fresh FNA specimen in one case and on paraffin-embedded surgical tissue in all eight cases, showed seven tumors to be aneuploid and one to be diploid. The authors contend that ICPCs of breast have distinct cytomorphologic features that can be recognized by FNA. Because ICPC may present in cyst fluid, either bloody or clear, all breast cyst fluids from postmenopausal women should be examined cytologically. Flow cytometric demonstration of an aneuploid population may assist in confirming malignancy in this lesion.

Aged↗
PubMed1987

The LINE-1 DNA sequences in four mammalian orders predict proteins that conserve homologies to retrovirus proteins.

Recent work suggests that one or more members of the highly repeated LINE-1 (L1) DNA family found in all mammals may encode one or more proteins. Here we report the sequence of a portion of an L1 cloned from the domestic cat (Felis catus). These data permit comparison of the L1 sequences in four mammalian orders (Carnivore, Lagomorph, Rodent and Primate) and the comparison supports the suggested coding potential. In two separate, noncontiguous regions in the carboxy terminal half of the proteins predicted from the DNA sequences, there are several strongly conserved segments. In one region, these share homology with known or suspected reverse transcriptases, as described by others in rodents and primates. In the second region, closer to the carboxy terminus, the strongly conserved segments are over 90% homologous among the four orders. One of the latter segments is cysteine rich and resembles the putative metal binding domains of nucleic acid binding proteins, including those of TFIIIA and retroviruses.

Amino Acid Sequence↗
PubMed1987

Diagnostic electron microscopy using fine needle aspiration biopsies.

Electron microscopy can be a valuable aid to light microscopy in the interpretation of fine needle aspiration biopsies of tumors, but considerable care in procuring and processing the specimen is necessary to recover the tumor cells and avoid altering their fine structure. Fixation followed by filtration through a cloth screen is recommended. Experience with this technique is briefly reviewed.

Adult↗
PubMed1985

Expandable biliary endoprosthesis: an experimental study.

Expandable stents constructed of stainless-steel wire were inserted in the extrahepatic bile ducts of five animals to determine the effect of the endoprosthesis on the ductal wall. The stents were left in place 4-23 weeks, at which time the bile ducts were inspected. The bile ducts remained patent in all animals. Relatively mild reactive inflammatory changes observed in the wall of the bile ducts were more pronounced in animals with stents in place for the longest periods. A relatively small-caliber catheter (9 French) was necessary for the introduction of the stent, which acquired a much larger diameter once it was released from the catheter. This study suggests that expandable wire stents could be safely used to relieve biliary obstruction.

Animals↗