Biomedical subjects

T Falco

Publications and source records attributed to T Falco.

6 recordsLinked to original sources

PubMed2004

Elimination of ghost markers during dual sensor-based infrared tracking of multiple individual reflective markers.

The accuracy of dose delivery in radiotherapy is affected by the uncertainty in tumor localization. Motion of internal anatomy due to physiological processes such as respiration may lead to significant displacements which compromise tumor coverage and generate irradiation of healthy tissue. Real-time tracking with infrared-based systems is often used for tracking thoracic motion in radiation therapy. We studied the origin of ghost markers ("crosstalk") which may appear during dual sensor-based infrared tracking of independent reflective markers. Ghost markers occur when two or more reflective markers are coplanar with each other and with the sensors of the two camera-based infrared tracking system. Analysis shows that sensors are not points but they have a finite extent and this extent determines for each marker a "ghost volume." If one reflective marker enters the ghost volume of another marker, ghost markers will be reported by the tracking system; if the reflective markers belong to a surface their "ghost volume" is reduced to a "ghost surface" (ghost zone). Appearance of ghost markers is predicted for markers taped on the torso of an anthropomorphic phantom. This study illustrates the dependence of the shape, extent, and location of the ghost zones on the shape of the anthropomorphic phantom, the angle of view of the tracking system, and the distance between the tracking system and the anthropomorphic phantom. It is concluded that the appearance of ghost markers can be avoided by positioning the markers outside the ghost zones of the other markers. However, if this is not possible and the initial marker configuration is ghost marker-free, ghost markers can be eliminated during real-time tracking by virtue of the fact that they appear in the coordinate data sequence only temporarily.

Algorithms↗

PubMed2002

Ultrasound imaging for external-beam prostate treatment setup and dosimetric verification.

Ultrasound (US) image-guided patient positional verification was performed daily on four prostate cancer patients using the BAT system (NOMOS Corporation, CA). The BAT system has shown that the prostate can shift by as much as 1 cm from its intended position in any direction. Furthermore, the daily shifts measured by the BAT system were included into the treatment planning system to assess changes in prostate dose coverage. Dose volume histograms were used to compare the dosimetry between the ideal patient set-up situation (prostate always positioned correctly) and that taking all patient daily shifts into consideration. Daily patient shifts on the order of magnitudes measured, can significantly and adversely affect dosimetric coverage, therefore an US-based patient positioning system is required for improving the therapeutic ratio.

Humans↗

PubMed1999

Setup verification in linac-based radiosurgery.

A semi-automatic technique for the direct setup alignment of radiosurgical circular fields from an isocentric linac to treatment room laser cross-hairs is described. Alignment is achieved by acquiring images of the treatment room positioning laser cross-hairs superimposed on the radiosurgical circular field image. An alignment algorithm calculates the center of the radiosurgical field image as well as the intersection of the laser cross-hairs. This determines any alignment deviations and the information is then used to translate the radiosurgical collimator to its correct aligned position. Two detectors, each being sensitive to the lasers and ionizing radiation, were used to acquire the radiation/laser images. The first detector consists of a 0.3-mm-thick layer of photoconducting a-Se deposited on a 1.5-mm-thick copper plate and the second is film. The algorithm and detector system can detect deviations with a precision of approximately 0.04 mm. A device with gyroscopic degrees of freedom was built in order to firmly hold the detector at any orientation perpendicular to the radiosurgical beam axis. This device was used in conjunction with our alignment algorithm to quantify the isocentric sphere relative to the treatment room lasers over all gantry and couch angles used in dynamic stereotactic radiosurgery.

Algorithms↗

PubMed1998

Preliminary study of a metal/a-Se-based portal detector.

A feasibility study has been performed on metal/amorphous selenium detectors for megavoltage portal imaging. The metal plates of the detectors were positioned facing the incident 6 MV and Co-60 photon spectra. The detectors consist of various thicknesses (0.15 mm, 0.30 mm, and 0.50 mm) of amorphous selenium (a-Se) deposited on metal plates of varying thicknesses: aluminum (2.0 mm), copper (1.0 mm and 1.5 mm), stainless steel (0.9 mm), or glass (1.1 mm). The detectors were charged prior to irradiation by corona methods, and the portal images were subsequently digitized after irradiation with a noncontact electrostatic probe. The sensitivity of the detectors to dose, electric field across the a-Se layer, metal plate type and a-Se thickness, was studied. The electrostatic voltage remaining on the a-Se layer was found, both theoretically and experimentally, to exhibit a cubic relationship with respect to dose. An increase in electric field increases the sensitivity (gradient of the a-Se surface voltage vs dose curve) and dynamic range of the resultant image. An increase in a-Se thickness, however, although also increasing the sensitivity, decreases the dynamic range. The metal plate types and thicknesses within the range studied do not have a significant effect on detector sensitivity. Image quality and contrast resolution of the detector were evaluated with a contrast-detail phantom and compared to commercially available film based and electronic portal imaging devices. Image quality of the metal/a-Se detector as a function of dose was studied by discharging the a-Se to various fractions of its initial charge, and as expected, increases with dose due to a decrease in quantum noise. Contrast-detail images obtained by metal/a-Se detectors are superior to those obtained at higher dose levels by other commercial systems.

Biophysical Phenomena↗

PubMed1998

Characteristics of metal-plate/film detectors at therapy energies. I. Modulation transfer function.

Measurements of modulation transfer function (MTF) for front and back metal-plate/film portal detectors are reported for the Cobalt-60 and 10 MV spectra. The detectors consist of a double-emulsion portal film secured between plates of Al, Cu, brass, or Pb with thicknesses varying from 0 to 4.81 mm. Secondary electrons produced within the front plate generate the main signal, but the MTF decreases with an increase in front plate thickness greater than the maximum range of electrons Rmax because of photon scatter in the front plate. Because the decrease of MTF with backplate thickness ceases for backplate thickness greater than Rmax, the MTF is influenced more by the backscatter electrons than the backscatter photons.

Biophysical Phenomena↗

PubMed1998

Characteristics of metal-plate/film detectors at therapy energies. II. Detective quantum efficiency.

Noise power spectrum (NPS) and detective quantum efficiency (DQE) for metal-plate/film portal detectors are reported for the Co-60 and Linac 10 MV spectra. The detectors consist of a double-emulsion portal film secured between plates of aluminum, copper, brass, or lead. The NPS was found to be independent of the detector sensitivity demonstrating that the film grain noise dominates over the quantum noise. Although the detector signal increases with density of the backplates, the resultant electron-backscatter increases detector blur, thus decreasing the DQE. The lowest DQEs are therefore produced with the lead backplates, irrespective of the front plates. For a given backplate and for front-plate thicknesses less than the maximum electron range, the DQE increases with density of the front plate.

Biophysical Phenomena↗