Lyme disease and antibiotic prophylaxis.
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Anti-Bacterial Agents↗
Biomedical subjects
T Fabrizio
Publications and source records attributed to T Fabrizio.
About the residents' working conditions in the USA.
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Employment↗
Medico-legal and ethical aspects of new methods of treatment for infertility using donor gametes.
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Ethics, Medical↗
Topical administration of tetrasodium-meso-tetraphenylporphinesulfonate (TPPS) and red light irradiation for the treatment of superficial neoplastic lesions.
In photodynamic therapy, systemic administration of photosensitizing agents induces cutaneous photosensitization in patients. This side-effect can be avoided by topical administration of the agents when only surface lesions are involved. A hydroalcoholic solution of tetrasodium-meso-tetraphenylporphinesulfonate (TPPS) containing Azone, a percutaneous penetration enhancer, was investigated to evaluate its photosensitizing potential in the treatment of 33 primary and recurrent neoplastic lesions of the skin. A complete remission was obtained of lesions with clinical thickness of less than 2 mm. Treatment effectiveness depends on both light and drug penetration through skin. Further studies are in progress to optimize treatment parameters.
Administration, Topical↗
Known viruses, new dangers.
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Acquired Immunodeficiency Syndrome↗
Free to total prostatic specific antigen ratio as a new diagnostic tool in prostatic carcinoma.
One hundred seventy-one patients with clinical suspicion of prostate cancer were initially selected and underwent total and free PSA determination, digital rectal examination and transrectal ultrasonography. Sixty-five had total PSA values between 4 to 20 ng/ml. In these patients in addition to the free to total PSA ratio, the sensitivity, specificity, positive predictive value, true and false negative predictive value were evaluated, comparing these findings with histopathological characterization. Receiver Operating Characteristic Analysis was also performed. No statistically significant differences were evidenced between benign and neoplastic prostates comparing total PSA values, while significant differences were found by comparing both free PSA and the free to total PSA ratio (p < 0.01). Our experience demonstrates that using a 0.20 free to total PSA ratio cut-off, it is possible avoid 44.4% of following clinical tests, and biopsies could be saved in almost 40% of patients with a considerable cost-benefit ratio.
Aged↗