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Biomedical subjects

T F Yü

Publications and source records attributed to T F Yü.

At least 37 records · Page 2Linked to original sources
PubMed1969

Plasma and urinary amino acids in primary gout, with special reference to glutamine.

Measurement of the plasma free amino acids by column chromatography (AutoAnalyzer) in 32 patients with primary gout showed statistically significant increases or decreases in several components when compared with the spectrum in 18 control subjects, but the absolute amounts involved were small and the mean total plasma amino acid concentrations in both groups were the same. In the urine all major amino acid components, notably glutamine, serine, threonine, and leucine, were lower in our gouty than in our nongouty subjects, as were also the corresponding renal clearance ratios. These deficits could be reproduced by restricting dietary protein, so appear to be due largely to the some-what reduced mean dietary protein intake of our gouty subjects. However, the low renal clearance of glutamine, the most striking and consistent of the deficits in urinary amino acids noted, could not be accounted for by dietary or other relevant factors, and is interpreted as indicating increased tubular reabsorption of glutamine in primary gout. This interpretation was supported by the results of glutamine loading. The possible compensatory relationship of the abnormality in renal handling of glutamine to the deficiency in renal production of ammonia previously reported is discussed.

Adolescent↗
PubMedDate not supplied

Rheumatoid nodulosis: an unusual variant of rheumatoid disease.

A middle-aged man developed multiple subcutaneous nodules associated with palindromic rheumatism. There was little evidence of synovitis; however multiple cyst-like intraosseous radiolucencies were noted. Nodules from two sites were histologically typical rheumatoid nodules. Subjective and objective improvement occurred during penicillamine therapy. This clincial presentation seems sufficiently distinctive to warrant characterization as a variant of rheumatoid disease termed by us: rheumatoid nodulosis.

Arthritis↗
PubMedDate not supplied

Pharmacokinetic and clinical studies of carprofen in gout.

Carprofen, a carbazole derivative, has been found to be highly potent as anti-inflammatory agent. After a single dose of 100 mg, plasma caprofen peaked in 1 to 2 hours, and t 1/2 was estimated to be 4.4 +/- 1.4 hours, based on a monoexponential fit of the data. Cumulative urinary excretion of total carprofen in 24 hours was almost 30% of the dose, chiefly as glucuronide conjugate. With simultaneous administration of carprofen and probenecid, peak plasma carprofen doubled. The t 1/2 was somewhat prolonged, and urinary excretion was significantly reduced. The t 1/2 of probenecid was not changed, and probenecid uricosuria was unaffected. Carprofen was found to be quite effective for acute gouty arthritis. The drug was well tolerated. Some mild diarrhea developed in one of the 14 patients. No other side effects were observed. The efficacy of carprofen for acute gouty arthritis deserves further trial.

Carbazoles↗