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Biomedical subjects

T F Williams

Publications and source records attributed to T F Williams.

84 records · Page 5Linked to original sources
PubMed1968

Sudden deafness.

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Adult↗
PubMed1967

Metabolism of vitamin D3-3H in vitamin D-resistant rickets and familial hypophosphatemia.

The fate of an intravenous dose of tritiated vitamin D(3) was studied in seven normal subjects, four children with vitamin D-resistant rickets, and four adults with a familial history of vitamin D-resistant rickets and persistent hypophosphatemia. An abnormal metabolism of vitamin D in vitamin D-resistant rickets was defined and characterized by a decrease in the plasma fractional turnover rate, a marked increase in plasma water-soluble metabolites, and a relative decrease in the conversion of vitamin D to a polar, biologically active metabolite. Alterations in vitamin D metabolism in the adults with persistent hypophosphatemia were similar but less severe than those of affected children with vitamin D-resistant rickets. It is tentatively concluded that the abnormalities in vitamin D metabolism documented in patients with vitamin D-resistant rickets and familial hypophosphatemia may account for the observed osseous and biochemical changes.

Adolescent↗
PubMedDate not supplied

Assessment of mobility and hand function in the elderly.

Assessment of mobility and of hand function is essential in evaluating the health status of older persons and enters into all decisions concerning the extent of supportive care needed and possible environments for safe and comfortable living. Elements of generally accepted assessment protocols, such as the Katz activities of daily living and others, include some measures of mobility and hand function. Until recently, most measures used have been relatively general and nonspecific and, although very useful in overall decision-making, have not been readily related to underlying pathophysiological processes, nor to more precise care plans. Recent and ongoing studies are addressing this issue. Technologies for determining mobility and hand function have now been developed and appraised for a number of uses. It has been shown that relatively simple but more precise measurements of hand function correlate highly with overall function and with the long-term care needs of older persons; risk factors for falls and related mobility problems can be explicitly identified and used as a basis for preventive efforts; and mobility and hand function measurements can play an important role in the assessment of patients with arthritis.

Activities of Daily Living↗