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T F Sandeman

Publications and source records attributed to T F Sandeman.

At least 37 records · Page 2Linked to original sources
PubMed1990

Accuracy of death certificates and mortality statistics in Victorian testis cancer deaths 1950-1977.

426 death certificates relating to testicular cancer in Victoria, from 1950 to 1977, were examined for inaccuracies in cause of death narrative and coding for cause of death statistics. the narrative was inaccurate in major diagnosis in 33 certificates (21 false positives and 12 false negatives) and 17 accurately written certificates were mis-coded (12 false positives and 5 false negatives). Review of the pathological terms used revealed 10 lymphomas incorrectly ascribed to germ cell malignancy. The term "seminoma" seems to have been employed as a generic term for testis tumour, only 50 per cent of the tumours so designated being confirmed as seminoma. It is concluded that although Victorian figures relating to mortality from testis cancer are reasonably accurate (for 337 cases for which relevant records were available the detection rate was 95%, the confirmation rate 96% and concordance 91%), little reliance can be placed on the recorded pathological sub-type.

Cause of Death↗
PubMed1989

Primary malignant mediastinal germ cell tumors: a study of eleven cases and a review of the literature.

From 1957 to 1988 eleven cases of primary mediastinal germ cell tumor were referred to the Peter MacCallum Cancer Institute (PMCI). Four were seminomas, three were mixed germ cell tumors, two were embryonal carcinomas and two were teratocarcinomas. Two of the eleven patients were female. For seminoma, surgical debulking and post-operative irradiation produced the best results. Mediastinal doses ranged from 30 to 37.5 Gy. Local control was achieved in all cases; two patients survive disease-free. The non-seminomatous germ cell tumors showed a significantly poorer survival with only one of seven patients remaining alive in remission at 15 months. One other case of non-seminomatous tumor remains alive but in relapse at 23 months. Attention is focused on the anterior position of primary germ cell tumors in the mediastinum. A review of the literature is presented.

Adult↗
PubMed1988

Results of adjuvant chemotherapy for low-stage nonseminomatous germ cell tumors of the testis with vascular invasion.

Vascular invasion has been well established as one of the prime prognostic indicators in nonseminomatous germ cell tumors of the testis (NSGCT). In a retrospective series of node negative or minimally involved patients by radiology, only eight of 28 (28.6%) survived when vascular invasion was detected, compared with 50 of 72 (69%) without vascular invasion. In 1977 a policy of adjuvant cytotoxics (vinblastine and bleomycin) was added to the radiotherapy which was standard postorchidectomy treatment at the Peter MacCallum Cancer Institute. When platinum-based combination regimens were found to be effective, the radiotherapy was discontinued. Only two relapses with the original treatment occurred with one death 10 years later. The modified Einhorn protocol used as primary postorchidectomy treatment has prevented relapse in all six cases in whom it was used. The overall survival rate at 2 to 10 years is 94%. There are important implications in these findings for the "watch policy" which is becoming increasingly popular. In our opinion patients should not be merely watched when histologic sectioning of the primary reveals invasion of the vessels, of whatever type, by the tumor. Instead they should be treated.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1988

Accurate English.

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Terminology as Topic↗
PubMed1985

Foreskin facts.

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Circumcision, Male↗
PubMed1985

Thymic seminoma and myasthenia gravis.

Computed tomography detected an enlarged thymus in a 27-year-old man with myasthenia gravis of recent onset. Pathological examination of the thymus revealed lymphoid hyperplasia and a thymic seminoma (or germinoma), which was arising as an intramural nodule in a thymic cyst. This is the first reported association of thymic seminoma, lymphoid hyperplasia, and myasthenia gravis.

Adult↗
PubMed1981

Constitutive heterochromatin (C-banding) studies in patients with testicular malignancies.

The heterochromatic index [qh/(p + q) X 100] is a quantitative measure of variations in the heterochromatic regions of C-banded cells which minimizes differential contraction of heterochromatic and euchromatic areas. Heterochromatic indices of the homologues of chromosomes #1, #9, #16, and Y were studied in the genotypes of 48 patients with germinal tumors and in 30 controls. The heterochromatic indices of chromosome #9 in patients showed statistically significant heteromorphism compared with controls. In addition, the heteromorphism was found to increase from the lower malignancy seminoma to the highly malignant teratoma. A similar but statistically nonsignificant pattern was seen in chromosome #16. No statistical difference in the mean of the heterochromatic indices was found in chromosomes #1 and Y. The difference in the mean heterochromatic index in chromosome #9 appeared to be due to an increase in the mean heterochromatic index in chromosome #9 appeared to be due to an increase in the amount of constitutive heterochromatin and not to a decrease.

Adult↗
PubMed1980

Radiation injury of the anorectal region.

The mechanisms of radiation damage to the lower bowel are reviewed. Acute, chronic and late sequelae are described. Considering the number of pelvic malignancies treated primarily by intracavitary and external beam radiotherapy, serious morbidity is comparatively rare. Technical factors leading to ill effects and the contribution of current and future trends in radiotherapeutic technique are briefly mentioned.

Anal Canal↗
PubMed1979

Symptoms and early management of germinal tumours of the testis.

The symptomatology and delay in diagnosis in a series of 502 germinal tumours of the testis were surveyed. Pain is much more commonly a feature than is usually appreciated and often leads to the condition being treated as inflammatory for much longer than it should be. Most surgical textbooks are not helpful in this regard. Delay in exploring the testis, and, particularly, delay in initiating follow-up therapy after orchidectomy, were associated with a higher stage of disease and poorer results, most clearly seen in nonseminomatous tumours. As the incidence of testicular tumours seems to be rising, a high index of suspicion in any abnormality of the testis in a post-pubertal male is advocated. Exploration through an inguinal incision for any mass or enlargement of the body of the testis not associated with dysuria and pyuria is essential. If a tumour is found, supplementary treatment must be given without delay. Judicious X-ray therapy, surgery and cytotoxic drugs can save most patients. Seminoma, in particular, can be cured, even in the advanced case.

Adult↗