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Biomedical subjects

T F Meaney

Publications and source records attributed to T F Meaney.

88 records · Page 5Linked to original sources
PubMedDate not supplied

The special environmental needs of magnetic resonance.

The addition of a magnetic resonance (MR) unit to a hospital radiology environmental poses many unique considerations. Large magnetic fields present health and safety considerations as well as a hostile environment for data recorded magnetically. Radio-frequency shielding is necessary to eliminate a source of background signal that interferes with patient examinations. Magnetic shielding may be necessary in some instances to prevent low-level magnetic field exposure of persons with artificial cardiac pacemakers. Superconducting magnets are heavy and large and may give off large amounts of helium which can temporarily replace the air in the magnet room. Possible solutions to these environmental requirements are presented.

Environment, Controlled↗
PubMedDate not supplied

Gd-DISIDA--a potential contrast agent for magnetic resonance imaging of the hepatobiliary system.

Gadolinium (Gd) labeled diisopropyliminodiacetic acid (DISIDA) was prepared by mixing a Gd solution and a DISIDA solution in appropriate proportions and at controlled pH. Optimal complexation was obtained at a Gd:DISIDA molar ratio of 1:2.5 and the pH of the final solution was 7.3 to 7.5. The complex was found to be stable both in vitro and in vivo. Gd-DISIDA (12.5 mumol/kg) was injected into mice, and T1 and T2 relaxation times of various tissues were measured and compared with those of normal tissues. Only the T1 values of the blood and the liver markedly decreased after Gd-DISIDA administration and also the reduction in T1 values depended on the dose of Gd-DISIDA. Magnetic resonance imaging of the rabbit liver showed considerable contrast enhancement at 30 minutes after administration of 12.5 mumol/kg of Gd-DISIDA.

Animals↗