Biomedical subjects
T F DeMaria
Publications and source records attributed to T F DeMaria.
Immunobarriers of the tubotympanum.
The tubotympanum is protected by an immune system in addition to the mucociliary, secretory (antibacterial substance), and phagocytic defense systems. The immune protection is provided by innate and adaptive immune systems. With the latter, the tubotympanum is protected by both the local (humoral and cellular) and the systemic immunity. The major immunoglobulins involved are IgG, IgM (SIgM), and SIgA, although IgE and IgD may also be involved.
Experimental otitis media in chinchillas. II. Comparison of the middle ear immune responses to S pneumoniae types 3 and 23.
The present study shows that two different serotypes of Streptococus pneumoniae (type 3 and 23) when inoculated through the bulla elicit distinctly different immune responses in chinchillas. The passive hemagglutination assay shows that type 3 is a better immunogen than type 23 and that type 3 primarily elicits immune responses in the middle ear. When class-specific antibody activity was measured with the red cell linked antigen-antibody reaction test, antibody activities of serum IgG to type 3 slightly declined and of effusion IgM and IgA to type 3 increased following type 3 infection, whereas following type 23 infection antibody activities of serum IgG to type 23 increased and no antibody activities of IgA and IgM to type 23 were present in the effusions.