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Biomedical subjects

T F Dagi

Publications and source records attributed to T F Dagi.

31 records · Page 2Linked to original sources
PubMed1986

Long-term, intermittent percutaneous administration of epidural and intrathecal morphine for pain of malignant origin.

Eight patients with intractable pain of malignant origin were treated by the surgical implantation of externalized catheters for percutaneous injection of morphine into the spinal epidural or the cerebral intraventricular space. Follow-up ranged from 48 hr to 1 yr. Four catheters (50%) malfunctioned mechanically and were repaired. Two were imputed in systemic infection and were removed. One patient developed paradoxical responses and discontinued catheter use. Every patient enjoyed excellent relief for a significant time with full preservation of mental capacities. The attractive simplicity of this morphine delivery system deserves further study.

Adult↗
PubMed1986

Ocular and endocrine function in patients with pituitary tumors. Operative results following transnasal, transsphenoidal approach with marsupialization of the sella turcica.

Thirty-one patients with pituitary tumors underwent transphenoidal operation via a unilateral, trans-nasal technique preserving the nasal septum and marsupializing the sella turcica unless CSF leak could be demonstrated. These two modifications neither detracted from exposure nor predisposed to delayed complications and significantly facilitated the procedure.

Adult↗
PubMed1983

Reformulation of the Papez circuit: absence of hippocampal influence on cingulate cortex unit activity in the primate.

Cingulate cortex (CC) unit responses to hippocampal volleys and afterdischarges were studied in 4 awake unsedated squirrel monkeys using extracellular microelectrodes. Stimuli were delivered via bipolar electrodes chronically implanted bilaterally in anterior and posterior hippocampus. A total of 412 units in 21 tracks were studied and tested to single and multiple shock stimulation. Spontaneous firing rates were approximately equally distributed among slow (0.25 spikes/s), medium (2.5-10), and fast (10-25). Only 2% of cingulate units (9/412) responded orthodromically to hippocampal stimulation: 5 with initial excitation; 4 with initial inhibition. Eight responses had initial latencies from 100-200 ms; one unit a latency of 25 ms. Three units displayed periodic, almost cyclical, excitation. All unit response thresholds were 1 shock, 0.25 mA or less. Hippocampal afterdischarge activity influenced the firing pattern of 17 units: 16 showed intraictal excitation and 1 inhibition. In comparison with the preceding studies in the same model these results indicate that the influence of hippocampal stimulation on cingulate cortex is not nearly as prominent as either the fornix or non-fornix hippocampal influence on hypothalamic, preoptic, and basal forebrain structures. It is proposed that the cingulate cortex is not a prominent link in the Papez circuit.

Animals↗
PubMed1983

The incidence and prevention of meningitis after basilar skull fracture.

The survey of 1,077 consecutive skull fractures admitted to the Massachusetts General Hospital between July 1, 1969 and July 1, 1979 were reviewed. One hundred sixty-eight basilar skull fractures (15.6%) were diagnosed according to clinical and radiological criteria. In 128 patients with basilar skull fracture but without CSF leak, two out of 65 patients (3.1%) who received prophylactic antibiotics developed meningitis in contrast to none of 63 patients who were treated. Nine of 15 patients with otorrhea developed meningitis regardless of treatment. Of 18 patients with rhinorrhea, 13 were treated with prophylactic antibiotics and were free of meningitis but 2 of 5 patients not treated (40%) did develop meningitis. The overall incidence of CSF leak was 20.8%. There is no clear evidence to demonstrate that prophylactic antibiotics are effective in general in reducing the incidence of meningitis after basilar skull fracture with active rhinorrhea. However, the difference in the incidence of meningitis between the treated and the untreated group was noteworthy though not statistically significant. Meningitis can develop despite antibiotic prophylaxis. Additional investigation and therapy should be considered whenever the clinical situation warrants.

Adolescent↗
PubMed1980

Villonodular synovitis in the spinal canal: case report.

Villonodular synovitis is believed to be an inflammatory, proliferative reaction of synovial tissues. The case of a 65-year-old woman with a cervical epidural mass is presented in which histological examination showed that the lesion was villonodular synovitis, an extremely rare occurrence. Because of its cellularity and occasional multinucleated giant cells, villonodular synovitis may be confused with metastatic malignancies or giant-cell tumor of bone.

Aged↗
PubMed1980

Metastatic trophoblastic disease presenting as a subarachnoid hemorrhage: report of two cases and review of the literature.

Trophoblastic tumors may present as subarachnoid or intracerebral hemorrhages in women of childbearing age. Although uncommon in Western countries, they constitute a significant percentage of metastatic lesions to the nervous system among Oriental women and usually follow molar pregnancies. Malignant transformation may occur at any time, but most frequently within a year of pregnancy. For this reason, close follow-up of women with molar pregnancies and subsequent prevention of pregnancy for one year is mandatory. Persistent serum human chorionic gonadotropin elevations are seen at some stage. Eighty percent of hydatidiform moles remit spontaneously, and the prognosis for persistent molar disease treated with chemotherapy and irradiation is good. The prognosis for choriocarcinoma, however, is less favorable. Subarachnoid hemorrhage may be the first and only sign of intracerebral bleeding into a metastatic lesion or leakage from a damaged vessel in which trophoblastic tissue has lodged. The triad of menstrual abnormalities, recent or remote pregnancy or abortion, and an acute cerebrovascular event with evidence of a mass lesion should suggest the diagnosis of metastatic trophoblastic disease in a woman of childbearing age.

Adult↗