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Biomedical subjects

T F Anderson

Publications and source records attributed to T F Anderson.

At least 37 records · Page 2Linked to original sources
PubMed1983

Pigmented purpuric lichenoid dermatitis of Gougerot-Blum mimicking Kaposi's sarcoma.

A case of pigmented purpuric lichenoid dermatitis of Gougerot-Blum is presented and the pertinent literature is reviewed. This case is unusual in that the lesions were unilateral and very limited in extent. The patient presented with a localized pigmented purpuric eruption of plaques on the dorsum of one foot which mimicked Kaposi's sarcoma. However, a biopsy confirmed the diagnosis of pigmented purpuric lichenoid dermatitis of Gougerot-Blum.

Adult↗
PubMed1982

Psoriasis.

Explore the source record for details and available documents.

Administration, Topical↗
PubMed1982

Etretinate therapy stimulates deposition of mucus-like material in epidermis of patients with psoriasis.

During therapy for psoriasis with the oral aromatic retinoid etretinate, a finely granular material was detected by electron microscopic examination of the epidermis of ten patients. Since this amorphous substance has some of the ultrastructural characteristics of mucin, it is called mucus-like material (MLM). MLM occurs occasionally in untreated psoriatic lesions; however, its deposition is enhanced by etretinate therapy. While MLM has not been fully characterized, evidence exists for the possibilities that it represents either cell products (such as mucin, or carbohydrates associated with the cell surface) or an exudate infiltrating the epidermis.

Etretinate↗
PubMed1982

Etretinate therapy causes increases in lipid levels in patients with psoriasis.

We investigated changes in serum triglyceride, cholesterol, and high-density lipoprotein cholesterol (HDLC) levels during etretinate administration in 21 patients with psoriasis. Mean serum triglyceride and cholesterol values showed a statistically significant increase during etretinate therapy compared with placebo treatment; mean HDLC levels did not change. During etretinate therapy, elevations out of the normal range occurred in 77% of the patients for serum triglycerides and 25% for serum cholesterol. Eight weeks after discontinuation of the drug regimen, patients' mean serum triglyceride and cholesterol levels were not statistically different from those found prior to therapy. Nevertheless, eight weeks after therapy had been stopped, six (32%) of 19 patients had cholesterol values that were still 20% or more above their baseline levels; the prolonged etretinate excretion time could have been responsible. The mechanisms for the etretinate-induced lipid elevations are unknown.

Adult↗
PubMed1980

Metabolic aspects of psoriasis: the basis for specific therapy.

Psoriasis, like diabetes, is a multifactorial genetic disease with complex interactions of deranged metabolism. Factors that affect epidermal differentiation and proliferation include cyclic nucleotide interactions, polyamine metabolism, cell surface--cytoskeleton interactions, and arachidonic acid--prostaglandin cascade. Evidence indicates that pharmacologic manipulation of the so-called critical metabolic systems not only may help us to understand the pathophysiology of psoriasis but also may yield improved treatments for the disease.

Arachidonic Acids↗
PubMed1978

Psoriasis and arthritis.

The relationship of psoriasis and arthritis is controversial. It has been reported that 7 percent of patients with psoriasis have arthritis. In approximately half of these cases, it is a sero-negative inflammatory polyarthritis, two-thirds of which clinically resemble rheumatoid arthritis. A distinctive peripheral arthropathy is displayed by 1 percent of psoriatics. One-fifth of this group, or less than 0.2 percent of psoriatics, suffer deforming arthritis multilans. The epidemiologic, clinical, radiologic, serologic, and genetic evidence for and against psoriatic arthropathy as a unique entity are reviewed. The prognosis of psoriatic arthritis appears to be better than previously suggested. Therapeutic measures are also reviewed.

Arthritis↗
PubMed1977

Glucocorticoid in inflammatory proliferative skin disease reduces arachidonic and hydroxyeicosatetraenoic acids.

Psoriasis is a prototype of several common, glucocorticoid responsive, inflammatory proliferative skin diseases. Within 28 hours, glucocorticoid reduced the increased concentration of free arachidonic acid in diseased tissue. This reduction was observed prior to visible improvement of disease and may be an important molecular mechanism for the therapeutic efficacy of glucocorticoids in psoriasis and similar inflammatory diseases.

Adolescent↗
PubMed1976

F' plasmids from HfrH and HfrC in recA- Escherichia coli.

We have isolated and characterized a number of clones resulting from matings of HfrH and HfrC cultures of Escherichia coli with auxotrophic recA- E. coli. As in Low's (1968) experiments, the recA- marker prevented integration of F' episomes into the vegetative chromosomes of the host. Both F'H F'C plasmids contained a great variety of non-selected nutritional markers. However, more F'H plasmids seemed to have expressed F+ characteristics than did F'C plasmids. These characteristics include (i) the presence of F-pili as determined by susceptibility to male-specific phages; (ii) fertility as determined by the merozygote's ability to transfer nutritional markers to an auxotrophic F- strain of E. coli; and (iii) a high degree of inheritability as estimated by the proportion of F' bacteria to F- bacteria in clones grown in a non-selective medium like broth. This proportion is seen to be affected by both factors that determine the probabilities that daughters of F' bacteria inherit the episome and from physiological factors that determine the rates of growth of F' and F- bacteria.

Coliphages↗
PubMed1975

Inheritability of plasmids and population dynamics of cultured cells.

The compositions of growing bacterial cultures containing F' plasmids are developed in theoretical terms that will be helpful in designating experiments to determine the genetic and physiological parameters involved. The genetic parameter is the inheritability of the plasmid defined as the probability, h, that a daughter bacterium will inherit the plasmid and thus be F' rather than F-. The value of h determines the chance that the plasmid will survive in a clone initiated by a single F' bacterium. If 0 less than or equal to h less than 0.5, the probability of plasmid survival is zero, whereas if 0.5 less than h less than 1 the survival is (2h - 1)/h2. While clone sizes are demonstrated to be erratic, the proportion of F' bacteria does converge to an equilibrium value if log2 h greater than alpha - 1, where the physiological factor, alpha, is the ratio between the division times of F' and F- bacteria. A general expression of this equilibrium is derived. The two cases of alpha = 0, implying that only the F' bacteria multiply on a selective medium, and alpha = 1, implying a completely nonselective medium, are analyzed in detail. It is shown that the above considerations apply generally to growing cultures of cells in which irreversible mutations occur.

Bacterial Physiological Phenomena↗