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Biomedical subjects

T Emori

Publications and source records attributed to T Emori.

84 records · Page 5Linked to original sources
PubMed1984

[A case report of post-traumatic syringomyelia].

A case of posttraumatic syringomyelia which appeared 26 years after the injury was presented. A patient was 61 year old female, who sustained thoraco-lumbar spine injuries rendering her to paraplegic in 1954. Eleven months later she had an operation of T6-T9 and L1-L2 laminectomies and regained motor and sensory functions of the both lower extremities. She was ambulatory with crutches till 1979. In 1980, burning pain was noticed in the left scapular region, and thereafter, extended to the ulnar side of the left forearm. The pain became progressively worse and intractable. Analgesics were ineffective. Two years later muscle atrophies and weakness in the left finger intrinsic muscles appeared. Absent deep tendon reflexes in the left upper extremity, dissociated sensory loss (in the left C2-S1 and right T5-T12 dermatomes) and paraparesis were also documented. Metrizamide CT scan performed 24 hours after the intrathecal injection disclosed an intramedullary syrinx between C2 and L1 vertebral levels. No communication with the fourth ventricle was seen. A syringoperitoneal shunt with low pressure valve was placed. The pain subsided immediately after this procedure. However, no improvement in motor and sensory functions were observed. Pathophysiological mechanisms involved in post-traumatic syrinx formation and its development were discussed. We prefer hypothesis proposed by Ball and Dayan to Gardner's hydrodynamic theory regarding to development of the syrinx secondary to spinal cord injury.

Female↗
PubMed1983

Tryptophan metabolism in analbuminemic rats.

Studies were made on tryptophan metabolism in Nagase analbuminemic rats (NAR), a mutant strain established from Sprague-Dawley rats that is characterized by lack of plasma albumin and hyperlipidemia. The total tryptophan concentration in NAR plasma is one fifth of normal, but the plasma free tryptophan concentration and liver and brain tryptophan levels are normal. Radioimmunoelectrophoresis showed that the tryptophan binding protein in NAR plasma is alpha 2-macroglobulin. The effect of oral tryptophan loading on plasma tryptophan and urinary excretion of tryptophan and its metabolites were examined. Differences between the values for NAR and normal rats were not significant except that the disappearance rate of tryptophan from NAR plasma was faster than in normal rats. The effects of several drugs that influence the concentration of non-esterified fatty acid (NEFA) or amino acids in the plasma of normal rats on NAR plasma tryptophan and NEFA concentrations and brain tryptophan metabolism were investigated. These drugs did not alter plasma NEFA and free tryptophan in NAR in the same direction as in normal rats. This difference may be caused by the difference of tryptophan binding proteins in the plasma of these two strains.

Amino Acids↗
PubMed1983

Age-related changes in plasma proteins of analbuminemic rats.

A mutant strain, Nagase analbuminemia rats (NAR), was established from Sprague-Dawley rats. Age-related changes in plasma proteins of NAR were investigated to obtain information of their abnormalities of protein metabolism. The total protein concentration in the serum of NAR of various ages was almost the same as that of normal rats of the same age. The albumin level of NAR was less than 0.05 mg/ml at all ages examined. The concentrations of serum alpha 1-antitrypsin, alpha-X protein, alpha 2-macroglobulin, transferrin, ceruloplasmin, IgG, IgA and IgM were higher in NAR than in normal rats except for the perinatal stage, but alpha 1-acid glycoprotein level in NAR was normal. The serum transferrin and ceruloplasmin levels were especially high in female adult NAR. The plasma fibrinogen concentration was also increased in NAR. These findings indicate that the normal total serum protein level of NAR was maintained by increase in the globulin concentration.

Aging↗
PubMed1983

[Moyamoya disease associated with persistent primitive trigeminal artery-Report of two cases].

Two cases of Moyamoya disease associated with persistent primitive trigeminal artery (PTA) are reported. Case 1: A 44 year-old man had sudden severe headache and found to have a subcortical hematoma in the left temporo-parietal lobe by CT-scans. Four vessel study revealed the right PTA and Moyamoya disease. Case 2: A 56 year-old woman suffered sudden severe headache and was diagnosed as subcortical hematoma in the right temporo-parietal lobe by CT scans. The left PTA and Moyamoya disease were revealed by four vessel study. In the previously reported 232 cases with PTA, we couldn't find out any case associated with Moyamoya disease. There are also no cases associated with Moyamoya disease in 93 cases of persistent primitive hypoglossal artery (PHA) whose vascular anomaly is essentially similar to that of PTA. In the 907 cases of Moyamoya disease collected by Japanese cooperative study, there were no cases in which PTA or PHA was associated by. The period when PTA or PHA disappears at the embryonic stage (5-14 mm) almost corresponds to the period (11-14 mm) in which the vascular state is similar to Moyamoya phenomena. From this point of view, two cases of Moyamoya disease associated with PTA suggest that there is a close relationship between Moyamoya disease and PTA. On the other hand, it seems that Moyamoya disease is associated with PTA by mere chance, because their combination is very rare and Moyamoya vessels changes frequently and dynamically, while PTA does not change.

Adult↗
PubMed1983

High incidence of renal tumors induced by N-dimethylnitrosamine in analbuminemic rats.

Analbuminemic rats were found to be highly susceptible to induction of renal tumors. Thirty-nine weeks after N-dimethylnitrosamine administration, the incidence of renal tumors and average weight of kidneys (including tumors) were 76.0% and 10.8 +/- 4.1 g in male analbuminemic rats, respectively, whereas they were 37.1% and 3.5 +/- 0.1 g, respectively, in normal male SD rats.

Animals↗
PubMed1982

Synthesis and secretion of plasma proteins by isolated hepatocytes of analbuminemic rats.

The synthesis and secretion of plasma proteins by isolated hepatocytes from the liver of Nagase analbuminemia rats (NAR) were investigated. NAR hepatocytes did not synthesize any albumin, but showed enhanced synthesis and secretion of several other plasma proteins, including transferrin, hemopexin, ceruloplasmin and fibrinogen. The lag period before the secretion of transferrin in NAR hepatocytes decreased. These findings indicate that the increased concentration of plasma globulins in NAR may be due to their enhanced synthesis and secretion in the liver.

Animals↗
PubMed1980

Absence of albumin in tissues of analbuminemic rats.

Nagase analbuminemic rats (NAR) are deficient in serum albumin. Extravascular regions of the tissues of NAR were tested for rat serum albumin by the immunofluorescence staining technique. Albumin was not detectable in any of the tissues of NAR tested (liver, kidney, muscle, skin, and small intestine), whereas it was clearly demonstrated in all these tissues of normal rats. Furthermore, extracts of NAR tissues, including the liver, contained no albumin detectable by the single radial immunodiffusion method. These findings indicate that albumin is not present in either the serum or extravascular regions of tissues of NAR, and suggest that the deficiency of serum albumin in NAR is not due to impaired albumin secretion from the liver or alteration of the tissue distribution of albumin in certain tissues, but to the absence of its synthesis in the liver.

Albumins↗
PubMed1979

[Comparative studies on release of enzymes from platelets during blood clotting in Rattus rattus flavitecus and Rattus norvegicus (author's transl)].

Increase of lactate dehydrogenase (EC 1.1.1.28) and creatine kinase (EC 2.7.3.2) in serum and plasma level during blood clotting was compared in R. rattus flavitectus (black rat) and R. norvegicus (albino rat). Both the enzyme level increased by the release from platelets in process of clotting in rat as previously described (Emori T., Takahashi M. and Nagase S. (1978) Exp. Animals, 27, 167), but the change in black rat was very slight. Owing to search for the reason to prove the difference in this phenomenon, physiological and chemical properties of blood from both the animals were compared, and it was demonstrated that the content of plasma fibrinogen in black rat is higher than that in albino rat, while the platelet number contained in each ml of blood and the enzyme activities in each platelet are not different between them. The analysis of the membrane proteins from platelets of both the animals by SDS-polyacrylamide gel electrophoresis showed that the fractional value of glycoproteins was found to be different between them.

Animals↗
PubMed1978

[Comparative studies on lactate dehydrogenase in serum and plasma of rats (author's transl)].

Values of serum and plasma LDH in rats were comparatively studied, and the following results were obtained: 1) The activity of LDH increased in serum with time during clotting, but no changes of LDH activity were found in plasma. 2) When platelet rich plasma (PRP) was recalcified and allowed to clot, LDH-release from platelets with a corresponding increase of serum LDH was observed, but addition of ADP or thrombin to PRP did not have an effect on LDH-release. 3) LDH-release from platelets by calcium was not inhibited by aspirin, and it was influenced by the quality of the test tube. 4) Values of serum and plasma LDH on experimentally induced liver-damaged or kidney-damaged rats and tumor-bearing rats were examined in relation to their tissue damages, revealing that plasma LDH activity represents the condition of a disease better than serum LDH activity.

Acute Kidney Injury↗
PubMedDate not supplied

Presence of two subcomponents in P9 far-field potential following stimulation of the median nerve.

Close scrutiny of scalp recorded P9 far-field potentials following stimulation of the median nerve often revealed dilobed wave forms. We observed that the P9 became 2 distinct peaks (P9a and P9b) when the arm was flexed 90 degrees forward at the shoulder and that it became a pointed single peak with 90-170 degrees lateral abduction of the arm. A simultaneously recorded stationary negative peak (N9), registered over the stimulated arm with the use of a distant reference, also showed similar changes, a dilobed configuration (N9a and N9b) with forward flexion and a single peak with lateral abduction. The latencies of the scalp recorded P9a and P9b and arm recorded N9a and N9b were close but not exactly the same. Nevertheless, the latencies of the scalp-positive and arm-negative peaks shifted in nearly a parallel fashion by changing the arm positions. These findings suggest that the change of axial orientation of the propagating nerve impulse plays an important role for the rise of P9a and that the change of volume geometry surrounding the nerve contributes to the P9b generation. Also, the scalp recorded P9 and arm recorded N9 are one and the same, and oriented with dipole fields extending from the arm, body and to the scalp.

Action Potentials↗
PubMedDate not supplied

Regional distribution of immunoreactive endothelin in rats.

By use of a specific radioimmunoassay for endothelin (ET), the regional distribution of ET-like immunoreactivity (LI) was studied in rats. The antiserum used cross-reacted equally with synthetic porcine and rat ET. Significant amounts of ET-LI are detectable not only in aorta, but also in kidney, lung, heart, liver and central nervous system. Gel chromatography of the tissue extracts revealed size heterogeneity of ET-LI; one major component eluting close to, but slightly larger than standard rat ET and the other minor component with a larger molecular weight. These data indicate that ET-LI is widely distributed throughout the various rat tissues, suggesting its possible involvement in a variety of organ functions.

Animals↗