Biomedical subjects

T Elbert

Publications and source records attributed to T Elbert.

At least 55 records · Page 3Linked to original sources

PubMed1998

Plasticity of plasticity? Changes in the pattern of perceptual correlates of reorganization after amputation.

We report a follow-up study on seven arm amputees in whom magnetic source imaging had originally revealed a strong correlation between the amount of cortical invasion of the deafferented cortex and the amount of pain evoked sensation mislocalized to the phantom limb. This re-examination was performed in order to corroborate the phenomenon of mislocalization. On follow-up examination for mislocalization 4 weeks later, a close correlation had remained between the original amount of cortical representational reorganization of the amputation zone (at the first examination) and the number of sites from where painful stimuli evoked sensations referred to the phantom limb, i.e. the amount of perceptual mislocalization, at the second examination. However, contrary to our expectation, the topography of referred sensation had completely changed in every patient. These results suggest that while the overall extent of reorganization is a rather stable phenomenon, the concomitant changes in the pattern of sensory processing are not. This may be due to the fact that alterations of sensory processing are not hardwired, but are rather mediated by an extensive and interconnected neural network with fluctuating synaptic strengths. This mechanism may be of importance for neurological rehabilitation.

Accidents↗

PubMed1997

Dynamical aspects of the EEG in different psychopathological states in an interview situation: a pilot study.

Dynamical brain states can be characterized by non-linear measures of EEG. The present study shows that critical transitions, i.e., abrupt changes from one dynamic pattern of neural mass activity to another one, may be detected by abrupt variations in local chaoticity. Using an ambulatory device, EEG was recorded from 10 patients with a schizophrenic and two patients with an affective disorder during a series of 25-min interviews. Dynamical aspects, in particular, phase transitions in the EEG-dynamics of the EEG were characterized by means of a measure that continuously estimates the chaoticity of the EEG signal and is thus related to its predictability. Results indicate simpler dynamics of the EEG time series in paranoid-hallucinatory patients, while at the same time these patients tended to exhibit more abrupt transitions/unit of time between different dynamical EEG states. Such sudden phase transitions in brain activity were significantly enhanced prior to expressions of thought disorders that were detected by the interviewer and an observer in the conversation, compared with time periods during the interview without such symptoms.

Adult↗

PubMed1997

Visually induced gamma-band responses to coherent and incoherent motion: a replication study.

The present study was based on earlier findings that the observation of a coherently moving long bar induced gamma-band activity in humans. The power in the EEG-gamma-band was reduced during the presentation of two incoherently moving short bars. The present study demonstrates the replicability of this cortical activity pattern and illustrates intersubjective variability in its topography. In addition, cortical alpha-activity was examined to test whether gamma-band activity might reflect changes in harmonics of alpha waves. Results indicate that induced gamma-band activity cannot be secondary to changes in the amplitude of alpha waves, since the latter would require both a similar time course of both frequency bands while stimuli are in motion and an identical topographical pattern. The present results suggest that oscillations in the gamma- and the alpha-bands are two different brain activities, with different functional implications.

Adult↗

PubMed1997

Differential outcomes from magneto- and electroencephalography for the analysis of human cognition.

Theoretical considerations show that magnetoencephalography (MEG) and electroencephalography (EEG) provide different information about ongoing human brain activity. The paper presents simultaneously measured MEG and EEG data showing that these measures may lead to different conclusions about cognitive models under investigation. This was demonstrated for amplitude results of the P300/N400 complex in a study of the secondary processing of lexical and non-verbal information in visual stimuli. As both methods provide different information about ongoing brain activity, their combined analysis is valuable. This seems particularly true for studies of higher order cognitive processing.

Analysis of Variance↗

PubMed1997

Magnetic brain imaging of extinction processes in human classical conditioning.

By recording neuromagnetic events during aversive classical conditioning, we examined the extinction of a previously described conditioned response. Averaging over non-reinforced exposures to the conditioned stimulus revealed magnetic activity in the secondary somatosensory and insular cortices, appearing between 110 and 140 ms after the omitted unconditioned electric shock. We suggest this activity to be elicited by the discrepancy between shock expectancy and perceptual processes associated with the omission of the unconditioned stimulus, reflecting one of several brain processes in extinction.

Adult↗

PubMed1997

Extensive reorganization of primary somatosensory cortex in chronic back pain patients.

The hypothesis of reorganization of the primary somatosensory cortex in states of chronic pain was assessed in 10 low back pain patients and nine matched healthy controls. Intracutaneous electric stimuli were applied to the left back and index finger at a standard, a non-painful and a painful intensity. Magnetic fields were recorded by a 37-channel BTi biomagnetometer from the hemisphere contralateral to the site of stimulation. The power of the early evoked magnetic field (< 100 ms) elicited by painful stimulation of the painful back in very chronic patients was elevated relative to that elicited by painful back stimulation of healthy controls and showed a linear increase with chronicity (r = 0.74). The maximum activity elicited in primary somatosensory cortex was shifted more medially in the very chronic back pain subjects. These data suggest that chronic pain is accompanied by cortical reorganization and may serve an important function in the persistence of the pain experience.

Adult↗

PubMed1997

Mapping EEG-potentials on the surface of the brain: a strategy for uncovering cortical sources.

This paper describes a uniform method for calculating the interpolation of scalp EEG potential distribution, the current source density (CSD), the cortical potential distribution (cortical mapping) and the CSD of the cortical potential distribution. It will be shown that interpolation and deblurring methods such as CSD or cortical mapping are not independent of the inverse problem in potential theory. Not only the resolution but also the accuracy of these techniques, especially those of deblurring, depend greatly on the spatial sampling rate (i.e., the number of electrodes). Using examples from simulated and real (64 channels) data it can be shown that the application of more than 100 EEG channels is not only favourable but necessary to guarantee a reasonable accuracy in the calculations of CSD or cortical mapping. Likewise, it can be shown that using more than 250 electrodes does not improve the resolution.

Brain↗

PubMed1997

Input-increase and input-decrease types of cortical reorganization after upper extremity amputation in humans.

A plastic remodeling of regions in somatosensory cortex has previously been observed to occur in separate experimental paradigms in response to loss of somatosensory input and to increase in input. In this study, both types of cortical reorganization have been observed to occur concurrently in the same adult human nervous system as a result of a single intervention. Following upper extremity amputation, magnetic source imaging revealed that tactile stimulation of the lip evoked responses not only in the area of the somatosensory cortex corresponding to the face, but also within the cortical region that would normally correspond to the now absent hand. This "invasion" of the cortical amputation zone was accompanied by a significant increase in the size of the representation of the digits of the intact hand, presumably as a result of an increased importance of sensory stimulation consequent to increased dependence on that hand imposed by the loss of the contralateral extremity.

Adolescent↗

PubMed1997

Possibilities and limitations of magnetic source imaging of methohexital-induced epileptiform patterns in temporal lobe epilepsy patients.

The usefulness of MEG-based techniques in lateralizing and localizing the epileptogenic area was investigated in the present study. Spontaneous and methohexital-induced spikes were studied in a group of 15 patients with temporomesial epilepsy using a 37-channel neuromagnetometer. The accuracy of the magnetic source imaging was compared to the results of electrocorticographic (ECoG) recordings. Differences of drug-induced spike densities in the MEG recordings between both sides confirmed a similar lateralizing power of the MEG and ECoG recordings. Source location analyses based on a moving dipole model resp. a rotating dipole model were performed using a spherical head model. After subdivision of the volume of each patient's head, 8 cm3 cubicles containing at least 3 source locations were projected onto the individual MRI scan and resulted in source locations within or close to the presurgically defined primary epileptogenic area only in 3 of the 15 patients. Spike induction by methohexital has the advantage of shortening the recording period as compared to recordings of interictal epileptiform discharges. However, the correlation analyses of spike densities from MEG and ECoG recordings and the source location analyses from MEG recordings indicate that spike generated in deep temporomesial structures may escape the MEG registration.

Adolescent↗

PubMed1997

Methohexital-induced changes in spectral power of neuromagnetic signals: beta augmentation is smaller over the hemisphere containing the epileptogenic focus.

Previous research has suggested that methohexital, a short-term barbiturate, alters activity in the primary epileptogenic area. It can be assumed that drug-induced activation of the epileptogenic focus provides a rapid and safe method to obtain a sufficient amount of information relevant for the lateralization and localisation of the primary epileptogenic area. This study shows that methohexital changes spectral power in the beta band derived from magnetoencephalographic (MEG) signals over the hemisphere ipsilateral to the primary epileptogenic area. This effect was demonstrated for 10/13 of the investigated patients suffering from unilateral temporal lobe epilepsy (TLE). The side and location of the primary epileptogenic area of these patients (5 left TLE, 8 right TEL) was determined invasively during presurgical evaluation. During a 1-2 minute interval after intravenous bolus injection of 100 mg methohexital a clear lateralization effect in the beta band was observed, which differed marginally between fronto-central, fronto-temporal and temporo-parietal brain regions. In addition, bilateral spectral power changes were obtained in the theta, alpha and gamma bands that differed between brain regions. Analyses of simultaneously recorded scalp electroencephalographic (EEG) data revealed effects consistent with those of the MEG analysis. The reduced enhancement of beta band spectral power of MEG recordings provides a potential application for the non-invasive lateralization of the primary epileptogenic area.

Adult↗

PubMed1997

Confidence interval of single dipole locations based on EEG data.

Noise in EEG and MEG measurements leads to inaccurate localizations of the sources. A confidence volume is used to describe the amount of localization error. Previous methods to estimate the confidence volume proved insufficient. Thus a new procedure was introduced and compared with previous ones. As one procedure, Monte Carlo simulations (MCS) were performed. The confidence volume was also estimated using two methods with different assumptions about a linear transfer function between source location and the distribution of the potential. One method used variable (LVM) and the other fixed dipole orientations (LFM). Finally, the confidence volume was estimated through a procedure in which there was no linearization of the transfer function. This procedure scans the confidence volume by varying the dipole location in multiple directions. Confidence volumes were calculated for simulated distributions of the electrical potential and for experimental data including somatosensory evoked responses to stimulation of lower lip, thumb, and little finger. Results from simulated data indicated that confidence volumes calculated with the MCS method were largest, and those calculated with the LFM method were smallest. For dipole locations close to the brain surface, the confidence volume was smaller than for a central deeper source. An increase in electrode density resulted in smaller confidence volumes. When the noise was correlated, only the method using the MCS produced acceptable results. Since the noise in experimental data is highly correlated, only the MCS method would appear to be useful in estimating the size of the confidence volume of the dipole locations. Thus, using real data with the MCS method, we easily distinguished separate and distinct representations of the thumb, little finger, and lower lip in the somatosensory cortex (SI). It was concluded that adequate estimation of confidence volumes is useful for localizing neural activity. On a practical level, this information can be used prior to an experiment for determining the conditions necessary to distinguish between different dipole sources, including the required signal to noise ratio and the minimum electrode density.

Brain↗

PubMed1997

[Visually-induced gamma band responses in human EEG- expression of cortical stimulus representation?].

The features of a visual stimulus are processed in different regions of the visual cortex with no direct axonal connections. Therefore, neurons in the distributed processing areas must be connected in some way to form the physiological substrate of the percept. On the basis of theoretical considerations and animal experiments, it has been proposed that synchronization of neuronal oscillatory firing patterns in the gamma band range (above 30 Hz) might be essential in linking the anatomically distant cell assemblies that represent the various features of the stimulus. The present work reports on three experiments in which the functional relevance of induced gamma band responses were investigated in the human EEG. Using an identical stimulation design, as used in animal studies, it was demonstrated that human induced gamma band responses resembled those reported from intracortical recordings from animals. It was further shown that alpha and gamma band activities differed in temporal characteristics as well as in topographical features, indicating the representation of different cortical functional states. In accordance with previous animal and human experimental findings, a complex moving stimulus was related to a suppression of induced gamma band activity as opposed to a standing complex stimulus.

Animals↗

PubMed1996

Tonotopic organization of the sources of human auditory steady-state responses.

Steady-state responses (SSRs) or steady-state fields (SSFs) show maximum amplitude when tone pulses are presented at repetition rates near 40 Hz. This result has led to the hypothesis that the SSR/SSF consists of superimposed transient 'middle latency' responses which display wave periods near 40 Hz and summate with one another when phase locked by 40 Hz steady-state stimulation. We evaluated this hypothesis by comparing the cortical sources of the 40 Hz auditory SSF with sources of the middle latency Pa wave which is prominent in electrical and magnetic recordings, and with the cortical sources of the familiar N1 wave, at different carrier frequencies between 250 and 4000 Hz. SSF sources determined for the different carrier frequencies were found to display a 'medial' tendency tonotopy resembling that of the N1m (sources for the higher frequencies represented more deeply within the supratemporal sulcus), opposite the 'lateral' tendency tonotopy of the middle latency Pam (sources for the higher frequencies situated more laterally). A medial SSF tonotopy was observed in each of the subjects investigated, including three subjects for whom Pam and N1m maps were also available. These findings suggest that the 40 Hz SSF may not consist of summated or entrained middle latency responses, as has previously been proposed. Alternative mechanisms for the SSR are discussed.

Acoustic Stimulation↗

PubMed1996

Modulation of auditory responses during oddball tasks.

The modulation of auditory input processing in relation to slow event-related potentials was examined in two studies. A steady-state response (SSR) was evoked by a stimulus train delivered at 40 Hz. Slow potentials were elicited by an oddball task implemented as changes in the pitch of single stimuli within this 40-Hz train. In study 1, subjects responded to rare targets by means of a button press. In study 2, subjects responded to targets by means of a motor response in one session and by silent counting in another session. In both studies, the oddball task elicited a P300 to targets. SSR amplitude was reduced 100 ms following each stimulus, while a second amplitude reduction around 350-400 ms was discovered following targets, in particular, following a button press. Parallel to SSR amplitude reductions, the latencies between stimulus and subsequent SSR peak were reduced. Results indicate that processing of oddball stimuli and motor responding alters 'automatic' auditory processing at the level of the primary auditory cortex; the second SSR amplitude reduction which develops in parallel to P300 might support the hypothesis that slow positive potentials indicate widespread (disfacilitation) inhibition of cortical neural excitability.

Adult↗

PubMed1996

Magnetic imaging in human classical conditioning.

Magnetoencephalography (MEG) was recorded during aversive classical conditioning in an attempt to elucidate the temporal coding of primary somatosensory cortex (SI) activation previously found with positron emission tomography. Four healthy volunteers participated in the experiment. The reinforced conditioned stimulus was displayed on a screen for 2 s, and as it disappeared an unconditioned electric shock to the right middle finger followed. A control stimulus, not paired with a shock was also presented. With MEG, we observed a conditioned magnetic response located in the SI. The conditioned response predated the shock presentation and is interpreted as evidence for functional control of nociception mediated by corticothalamic projections.

Conditioning, Classical↗

PubMed1996

The cortical representation of object motion in man is interindividually variable.

Cortical areas processing visual motion have been well investigated in monkeys, but comparatively little is known about these areas in man. In order to define such cortical areas in the brains of individuals, the magnetic field was recorded while subjects were watching motion-defined static and moving objects. The magnetic response showed a transient component with a clear dipolar magnetic field followed by a sustained component which exhibited some variation in magnetic field structure over time. For the transient component, the single equivalent current dipoles superimposed upon magnetic resonance images for individual subjects were clearly localized outside the primary visual areas. In most cases the neural generator was found in the region of the temporo-parieto-occipital junction of the lateral cortex. The results also suggest that the activated cortical area show interindividual variations in location.

Adult↗

PubMed1996

PRES- and orthostatic-induced heart-rate changes as markers of labile hypertension: magnitude and reliability measures.

Split-half and test-retest reliabilities of heart-rate responses to a baroreceptor manipulation and an orthostatic maneuver were compared between subjects with either normal or elevated blood-pressure. Ten subjects showing elevated resting blood-pressure and II normotensive subjects participated in two experimental sessions, each including heart-rate recordings during baroreceptor manipulation and orthostatic challenge. Carotid baroreceptors were manipulated by applying the baroreceptor-specific phase-related external suction (PRES) technique. The orthostatic stimulation procedure (OSP) was a change of body position from lying to standing. Heart rate responses evoked by OSP failed to discriminate significantly between the groups either in the magnitude or the (test, retest) reliability measure. The PRES procedure also failed to discriminate with the conventional magnitude measure, but the reliability measures showed significant differences. Paradoxically, the high-blood-pressure group manifested the higher baroreceptor reliability. The present findings are consistent with the view that operant conditioning produces phasic blood-pressure increases. In this view, blood-pressure increases activate the arterial baroreceptors which, in turn, dampen pain and/or stress sensitivity. Individuals showing high consistency (reliability) in their cardiovascular responses are more likely to learn this form of conditioning, and hence to eventually increase their tonic blood-pressure. High reliability of cardiovascular responses may therefore constitute a risk for hypertension. Aside from such theoretical considerations, the findings indicate that less conventional dependent variables like reliability may be worth exploring in the search for the etiology of essential hypertension, and that, in this search, specificity (relative to baroreceptor function) is more important than the magnitude of the heart-rate changes that are produced.

Adult↗

PubMed1996

Visually induced gamma-band responses in human electroencephalographic activity--a link to animal studies.

Visual presentation of an object produces firing patterns in cell assemblies representing the features of the object. Based on theoretical considerations and animal experiments, it has been suggested that the binding of neuronal representations of the various features is achieved through synchronization of the oscillatory firing patterns. The present study demonstrates that stimulus-induced gamma-band responses can be recorded non-invasively from human subjects attending to a single moving bar. This finding indicates the synchronization of oscillatory activity in a large group of cortical neurons. Gamma-band responses were not as apparent in the presence of two independently moving stimuli, suggesting that the neuronal activity patterns of different objects are not synchronized. These results open a new paradigm for investigating the mechanisms of feature binding and association building in relation to subjective perception.

Animals↗