Search PubMed⌕ Search

Biomedical subjects

T Egsmose

Publications and source records attributed to T Egsmose.

24 records · Page 2Linked to original sources
PubMed1966

A serological test in tuberculosis. A "blind" trial of the kaolin-agglutination test (KAT) for detection of tuberculosis antibodies.

Takahashi reported in 1962 that his kaolin-agglutination test (KAT), using the phosphatide fraction of Mycobacterium tuberculosis as antigen, was capable of detecting specific antibodies in sera from patients with pulmonary tuberculosis, and that the test could differentiate between active and inactive disease.The present study was designed to investigate the diagnostic efficiency of the KAT under conditions that prevail in Africa. Blood specimens were obtained from various categories of people, ranging from presumably healthy tuberculin-negative persons to patients with far-advanced pulmonary tuberculosis, and these specimens were submitted "blindly" for serological testing.The results showed that the KAT was less sensitive and also less specific in Kenya than it had been found in Japan by Takahashi. Some reasons for this discrepancy are discussed, but no final conclusion is reached.

Adolescent↗
PubMed1965

The use of isoniazid among household contacts of open cases of pulmonary tuberculosis.

A controlled and double-blind study to determine the efficacy of isoniazid in preventing the development of pulmonary tuberculosis among the household contacts of open cases of the disease has been carried out in a rural area of Kenya-a financially handicapped country-under realistic field conditions.A one-year course of isoniazid (5-10 mg per kg of body-weight in one daily dose) administered to the contacts of active cases gave a reduction in respect of the excretion of tubercle bacilli of the order of 90% at the end of the year. In the subsequent observation period (2-4 years) both the control and the isoniazid-treated group showed a low and similar rate of adverse findings.Previous studies by the Tuberculosis Chemotherapy and BCG Centre, Nairobi, had revealed that the risk of tuberculosis among household contacts, especially children, was high and, further, that the acceptability of the drug and the regularity of drug-taking were poor among these contacts. Even so, a very considerable prophylactic effect of isoniazid was demonstrated in the present study. It therefore seems justifiable to conclude that the treatment of household contacts with isoniazid could contribute to tuberculosis control in financially handicapped countries, particularly where a tuberculosis case-finding programme is reasonably well established.

Adolescent↗