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Biomedical subjects

T E Welty

Publications and source records attributed to T E Welty.

23 records · Page 2Linked to original sources
PubMedDate not supplied

A comparison of phenytoin dosing methods in private practice seizure patients.

In an attempt to evaluate the accuracy of phenytoin (PHT) pharmacokinetic dosage adjustments in a private practice setting, three single dose-concentration pair methods and three multiple point PHT pharmacokinetic dosing methods were studied. Dose and concentration data from 28 patients seen in a private neurology practice were utilized for the study. From a comparison of these methods in private practice seizure patients, it appears that the Bayesian feedback method may be the most accurate in making routine PHT dosage adjustments, perhaps by minimizing the contribution of unknown variables within the Bayesian approach.

Humans↗
PubMedDate not supplied

Progabide-induced changes in carbamazepine metabolism.

Carbamazepine (CBZ) and carbamazepine 10,11 epoxide (CBZ-E) concentrations were measured during a safety and efficacy trial of progabide. The average CBZ and CBZ-E serum concentrations were calculated from serial measurements during placebo and active treatment periods. Significant decreases in CBZ and significant increases in CBZ-E were observed after the first dose of progabide, and these changes persisted during 3 months of active treatment. Ninety-five percent of the patients had increases in the epoxide/CBZ ratio at the end of 3 months of treatment. These changes are consistent with displacement of CBZ from protein binding sites and inhibition of CBZ-E metabolism induced by progabide and are analagous to the interaction between valproate and CBZ.

Adolescent↗
PubMedDate not supplied

Intramuscular tobramycin pharmacokinetics in geriatric patients.

Twelve elderly institutionalized patients (mean age of 81 years) received intramuscular injections of tobramycin for infections at regular dosage intervals. The subjects had stable renal function but had limited mobility. Periodic blood specimens were collected for eight hours and analyzed for tobramycin by an immunofluorescence technique. The procedure was repeated in each patient one day later to detect day-to-day variability in the absorption kinetics. The absorption of tobramycin occurred primarily within two hours, although peak concentrations in some patients were indicative of a sustained plateau and exhibited intrapatient variability from one dose to the next. The time to peak and slowly declining concentrations suggest that the absorption process is extended in this population as compared to younger adults. Our data suggest that peak tobramycin concentrations following intramuscular injections to geriatric patients may be slightly delayed, though the extent of absorption appears to be consistent.

Aged↗