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Biomedical subjects

T E Larsen

Publications and source records attributed to T E Larsen.

50 records · Page 3Linked to original sources
PubMed1975

Gastrointestinal investigations in dermatitis herpetiformis.

Thirty-seven patients with dermatitis herpetiformis (DH) have been investigated for gastric and small intestinal abnormalities. Evidence of an enteropathy was found in 86% of the patients who had IgA deposits in uninvolved skin. Villous atrophy of the small intestine was found in 29 patients. About one-half of the patients had reduced absorption of xylose and vitamin A. The Schilling test value was lowered in one-third. Serum B12 was too low in 5/28 patients whereas folic acid in serum and whole blood was too low in 14/29 and 5/19, respectively. Atrophic gastritis occurred in 14/28 patients and only about one-third of the whole patient material had normal gastric mucosal structure and secretion.

Adolescent↗
PubMed1975

Deposition of fibrinogen (FR-antigen) in skin diseases. II. Pustulosis palmaris et plantaris (with special reference to heparin-precipitable fraction).

Ten out-patients with pustulosis palmaris et plantaris were examined with direct immunofluorescence (IF) technique for deposition of fibrinogen, fibrin or its degradation products (FR-antigen) in affected and unaffected skin, together with heparin-precipitable fraction (HPF), cryoglobulin and total plasma fibrinogen in the blood. FR-antigen was found in all cases in affected skin as a uniform pattern of a continuous ramification below the dermo-epidermal junction. This IF picture was absent in unaffected skin, but in other parts of the dermis in affected and unaffected skin, scattered streaks of IF could be seen. In one case, however, unevenly distributed IF was found in unaffected skin in the junction area. The scattered IF was also present in a minor degree in affected and unaffected skin in a control material of other dermatoses. Only one patient had slightly elevated values of HPF (0.33 mg/ml). Total plasma fibrinogen was insignificantly elevated, and no cryoglobulin could be found.

Adult↗
PubMedDate not supplied

The clinical importance of DNA synthesis and aneuploidy in bone and soft tissue tumours.

DNA flow cytometric analysis including the analysis of S-phase fraction was performed on 46 bone and soft tissue tumours. Histologically, 24 lesions were benign, 11 were low grade and 11 were high grade malignant tumours. The percentages of aneuploidy in these groups were 29, 54 and 82, respectively. The S-phase fraction was smaller than 14% in all benign tumours. High S-phase fraction (> or = 14%) was found in 3 out of 11 low-grade tumours (27%) and in 9 out 11 high-grade tumours (82%). Seven of nine patients who died of metastatic disease during the average 5 year follow-up had aneuploid stemlines with S-phase fraction higher than 14%. Histologically, these were all high-grade tumours. Three patients with high S-phase in low-grade tumours survived. We conclude that high DNA synthetic activity in an aneuploid population, more than the DNA aneuploidy alone, has prognostic significance in musculoskeletal tumours.

Adolescent↗