Biomedical subjects
Publications and source records attributed to T E Allen.
A case of an asymptomatic posterior mediastinal thoracic duct cyst diagnosed with fluoroscopically guided needle aspiration is reported. Previously, the diagnosis of thoracic duct cyst was established surgically and more recently was established by lymphangiography. To the authors' knowledge, diagnosis using needle aspiration has not been reported.
While having no antitumor effect per se, caffeine substantially enhanced the antitumor effects of the phleomycins PLM-CHP and PLM-PEP, and the bleomycins BLM-CHP and Blenoxane in rats carrying Walker 256 carcinosarcoma and/or mice carrying Ehrlich ascites tumor, even at doses of phleomycin and bleomycin below the minimum effective level. Positive but less conclusive results were also obtained with PLM-A4A4G and PLM-G.
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Significant and often substantial enhancement of the antitumor properties of several individual phleomycins , by co- administration via intraperitoneal injection of a number of purine analogues, is demonstrated in rats and mice having three diverse tumors. It is evident that the dose levels of both the phleomycin and the amplifier are very significant and that optimal levels vary widely with the actual agents used. Constant serum levels of amplifier can be maintained for several days by administration via silastic-pellet implantation rather than injection, and this route of administration is an effective alternative for amplifiers of low solubility.
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Prenatal factors known to be associated with delivery of an infant with low birth weight (LBW) were studied in 165 women who were delivered of infants of 25,000 gm or less, as well as 154 women who were delivered of term infants with normal birth weights (greater than 2,500 gm). Data included information related to th clinical course of the pregnancy through 24 weeks' gestation. Of 25 characteristics measured prenatally, 10 variables were identified with indicated differences between the LBW and normal birth weight groups sufficient to make them suitable for a discriminant analysis. Following further analysis and attribute reduction, eight variables were selected as the final set of discriminating attributes. These are: maternal age, height, and weight, the patients's perception of her own parental treatment as a child, presence of uterine anomalies, bleeding during pregnancy, suspected multiple gestation, and number of previous pregnancies ending with a gestational age of 13 through 36 weeks. On the basis of coefficients derived for each of these variables, an equation was developed to derive a discriminant score for each patient. With the use of such equations, 73.5% of the known cases were correctly classified into groups with low and high birth weight. A similar high correct classification of cases was made when suspected multiple gestation was excluded as a variable.
Cardiac output (Q), heart rate (HR), stoke volume (SV), and arteriovenous oxygen difference (AVD) were measured in 16 high school wrestlers during submaximal work (65%Vo2 Max) at normal weight (T1), after a four or five percent weight loss (T2), and following one hour of rehydration (T3). Weight losses were accomplished over 48 hours by fluid and food restriction as well as intermittent exercise. An ad libitum volume and commercial glucose-electrolyte solution was used to rehydrate the subjects. At T2 the mean weight loss was 4.6%, with the average plasma deficit estimated to be 4.9%. Under these conditions significantly higher HR and lower SV were observed during standardized exercise. Although Q was 7.8% lower and AVD was 7.3% higher after dehydration, neither change was statistically significant. Following rehydration all dependent variables returned to near T1 levels. It was concluded that despite a short rehydration period, the cardiovascular dynamics of these high school wrestlers rapidly returned to normal during moderately heavy work because of the small plasma changes that accompanied the 48-hour weight loss.
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