Biomedical subjects
Publications and source records attributed to T Dzik.
The analysis of incorrect evaluation of permanent consequences resulting after hepatitis B has been conducted. False diagnostical and expert evidence in evaluation of permanent effects after hepatitis B influenced to disadvantage the decisions concerning disability and compensation payments.
Among 140 patients with acute leukemia (AL) diagnosed according to FAB criteria, pericarditis was diagnosed clinically in 5 of them. They were 2 women and 3 men with different types of AL (L2-in one, M2-in one, M3-in one and M4-in two persons). It occurred in one patient at the onset of the disease and was associated with hyperuricemia, in another one--in complete remission, in the third--during partial remission, and in remaining two patients--during induction therapy. In all patients pericarditis was manifested by fever up to 38-40 degrees C, tachycardia and pericardial friction, in 3-heart silhouettes were enlarged. The ECG revealed mainly depression of ST segments. In 1 case only ECG pattern was typical of pericarditis. Clinically the symptoms of right ventricle failure predominated in 3 and of septic shock--in 2 patients. The etiologic factors were: Pseudomonas aeruginosa 2 X, Enterobacter cloacae 1 X, tuberculosis infection 1 X and hyperuricemia and Enterobacter sepsis 1 X. Pericarditis was favourably influenced by treatment with antibiotics, cardiaca and diuretics in 4 patients. One patient died of a sepsis. In no case the patient's death was attributable to pericarditis. The results of postmortem examinations in 79 cases of AL has revealed three additional cases of pericarditis due to tuberculosis infection, Staphylococcus aureus sepsis and aspergillosis.
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In connection with extending the therapeutic application of colchicine to include its use in the treatment of liver fibrosis in cirrhosis and possible harmful effects of this drug on other organs, the pancreas in particular, the authors studied this problem experimentally. For this purpose a model of experimental cirrhosis in rats produced with chronic administration of carbon tetrachloride was used, and in the third and ninth months of the experiment the activity of alpha-amylase and gamma-amylase was determined in the serum and pancreatic homogenate. The results did not show any unfavourable effect of colchicine administered in their therapeutic doses for long time periods on the pancreas in experimental rats and in healthy controls.
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