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Biomedical subjects

T Doi

Publications and source records attributed to T Doi.

At least 433 records · Page 24Linked to original sources
PubMed1987

[Clinical observation of bacterial isolates from urine specimens of outpatients].

Changes of bacterial isolates from urine specimens of outpatients with urinary tract infections (UTI) from 1977 through 1984 were studied. Organisms which were isolated from patients with bacteriuria of over 10(3) bacteria per ml of urine regardless of grade of pyuria were studied. The incidence of UTI, especially that of acute cystitis was decreased during the recent 8 years. E. coli was the most predominant isolate in acute UTI with an isolation frequency of over 70% every year, followed by S. epidermidis nearly every year. Citrobacter spp., Klebsiella spp., P. mirabilis and S. aureus were also isolated steadily every year. Bacterial isolates in acute UTI were generally composed of these six species of bacteria. Although many kinds of bacteria were isolated in chronic UTI, E. coli was the most frequent species with an isolation frequency of 17-37%, followed by E. faecalis except in 1981 and 1982. The tendency of gram-negative rods to increase in acute and chronic UTI was observed except in 1981 and 1982. A slight decrease in sensitivity of E. coli and P. mirabilis against ampicillin (ABPC) and sulbenicillin (SBPC) was observed in acute UTI. In chronic UTI, the tendency of the sensitivity of E. coli against ABPC, SBPC and nalidixic acid to recover and the tendency of the sensitivity of P. aeruginosa against dibekacin to decrease were observed. E. faecalis was estimated to be sensitive to gentamicin, cefazolin, minocycline and fosfomycin. However, unlike those species mentioned above, many strains of E. faecalis showed a positive disc sensitivity to these drugs.

Acute Disease↗
PubMed1986

[Disease structure of day-labourers from clinical records of a clinic in Kitakyushu].

For the purpose of the observation of disease structure of day-labourers, clinical records of a private S-Clinic whose specialties was internal medicine and gastroenterology were adopted. This clinic stands in an area where there are many boarding houses for day-labourers in Kitakyushu. Disease structures of the persons insured with Day Labourers Health Insurance (D. L. H. I.) were compared to those of the persons insured with another medical insurance from clinical records in 1977, 1980 and 1983. In result, the followings were noted. 1) The persons insured with D. L. H. I. were 29 males and 11 females in 1977, 24 males and 5 females in 1980, and 10 males and 11 females in 1983. Proportion of the number of the persons insured with D. L. H. I. in S-Clinic was higher than that of Japan. 2) The mean age of the person insured with D. L. H. I. was slightly higher than that with another medical insurance. Especially there were many females in an age group of 65 to 69 years old. 3) In the observation for the persons insured with D. L. H. I. compared to those with another medical insurance, the mean number of first visits was relatively small in 1980 (both male and female) and in 1983 (male), but the mean number of diseases per first visit was relatively large. The most of all kinds of diseases of first visits was the digestive system, the second was the respiratory system and the third was the circulatory system, being similar to the persons insured with another medical insurance.

Adult↗
PubMed1986

[Obesity index and blood pressure of workers in Kitakyushu].

Relation between obesity index and blood pressure of male, 40-49 years old, workers (11,526 persons) were observed, classified by industry (total industry, construction, manufacturing, transport & communication) and by occupation (total occupation, field workers, office workers) from a source of periodic health examination (April to September in 1982) of establishments in Kitakyushu. In results, the followings were noted. Proportion of number of subjects with hypertension in office workers was higher than that in field workers, except transport & communication. Hypertension depended on abnormal diastolic blood pressure was more than abnormal systolic blood pressure. Proportion of the number of subjects with abnormal blood pressure was high in construction, in transport & communication and in manufacturing, in order. Classified by obesity index, proportion of number of subjects with hypertension was high in construction and in manufacturing, in order. There were significant positive correlations between obesity index and blood pressure (both of diastolic and systolic) in all industries and in all occupations. Both distributions of obesity index by the KATO method and the MINOWA method had high positive skewness. Proportion of the number of subjects with hypertension, classified by obesity index, increased with obesity index. Obesity indices by the KATO method and the MINOWA method were seemed to be appropriate for the observation of relations between obesity index and blood pressure.

Adult↗
PubMed1986

Combination of cefmenoxime and cefsulodin in the treatment of complicated urinary tract infections caused by Pseudomonas aeruginosa.

The clinical efficacy of the combination therapy with cefmenoxime plus cefsulodin was studied in patients with complicated urinary tract infections caused by Pseudomonas aeruginosa. Patients received 1 g of CMX and 1 g of CFS concomitantly twice a day by 1-hour intravenous drip infusion. Of a total of 127 patients who received medication, 82 patients were evaluated on the 5th day. The overall clinical efficacy of treatment was evaluated by the criteria proposed by the UTI Committee, Japan, as excellent, moderate or poor. It was excellent in 15%, moderate in 55% and poor in 30%. Of the 143 strains isolated from 82 patients, 115 strains (80%) were eradicated. The eradication rate of P. aeruginosa was 83%. Subjective side effects were observed in 3 (2.4%) of the patients. Drug-related aggravations in laboratory test results were observed in 8 (7.5%), but most of them were minimal and reversible. The results of this study suggest that a combination of cefmenoxime and cefsulodin might be useful in the treatment of complicated urinary tract infections caused by P. aeruginosa.

Candidiasis↗
PubMed1986

[Effects of ipriflavone (TC-80, an anti-osteoporotic drug) on acute and chronic pain].

The effects of TC-80 on acute and chronic pain in rats and mice were examined. Single oral administration of TC-80 at 50-300 mg/kg was not analgesic in the phenylquinone writhing, acetic acid writhing, and hot plate tests in mice or the tail flick test in rats. Three-weeks administration of TC-80 in a dose of 100 mg/kg/day, p.o., to rats had no analgesic action in the acetic acid writhing and tail flick tests. When TC-80 was given orally in a dose of 100 mg/kg/day for 3 weeks to rats with adjuvant arthritic chronic pain, analgesic effects were observed 2 weeks after the start of administration in males and in ovariectomized estrone-supplemented females; the effect seen in the females was statistically significant. Changes in the bones of the hind paws were examined radiologically, and synovitis, periosteal new bone formation and bone destruction were examined histopathologically in the females. These variables were improved by treatment with TC-80 for 3 weeks. It is concluded that TC-80 has no analgesic effect, but may inhibit chronic pain by anti-osteoporotic action on bone disease.

Administration, Oral↗
PubMed1986

[Clinical studies on doxycycline in the treatment of nongonococcal urethritis by Chlamydia trachomatis].

Twenty-one nongonococcal urethritis patients by Chlamydia trachomatis infection were treated with doxycycline (DOXY, Vibramycin) 200 mg/day orally for 2 weeks. The age of these patients were ranged from 17 to 52. C. trachomatis was eradicated 8(89%) of 9 cases on 3rd day and never reisolated on 7th day after treatment. Ten (83%) of 12 patients on 7th day and any patients on 14th day were not suffered from symptoms after treatment. Urethral discharge was not seen macroscopically, 11 (92%) of 12 patients on 7th day and any patients on 14th day. According to the criteria for urethritis requiring at least 4 WBC per high power field in urethral smear and/or first voided urine, the overall clinical efficacy rate was 44% (4/9) on 3rd day, 83% (10/12) on 7th day and 100% (9/9) on 14th day. No side effects were recognized in any cases. In conclusion, DOXY was thought to be useful and safe drug in the treatment of nongonococcal urethritis by C. trachomatis.

Adolescent↗
PubMed1986

[A case of leiomyosarcoma of the urinary bladder].

A case of leiomyosarcoma of the urinary bladder in a 33-year-old female is reported. She was admitted with the complaint of gross hematuria. Cystoscopic examination showed a thumb-tip sized mass, located at the dome. CT showed a wide-based tumor at the dome (CT number was 60.2 H.U.). Segmental resection of bladder was performed, followed by radiation and chemotherapy (VCR, ACT-D, CPM and ADM). She is alive without evidence of disease 13 months after surgery. A case report and review of the literature are presented.

Adult↗
PubMed1986

[Subdural hematoma associated with dural carcinomatosis of gastric cancer and DIC].

We report a rare case of subdural hematoma associated with dural carcinomatosis of gastric cancer and DIC. Such subdural hemasma is supposed to be caused by tumor cell embolism in the dural vessels and DIC. Most cases show acute clinical symptoms such as consciousness disturbances, and their prognosis is extremely poor.

Adenocarcinoma↗
PubMed1986

[Detection of polyamines by a new enzymatic differential assay. (4). Fundamental study on a new enzymatic differential assay of blood].

The enzymatic method for isolation and determination of urinary polyamines was modified to measure the polyamines in the blood. High recovery rates of polyamine in blood by enzymatic hydrolyzation were obtained, namely, 101.9 +/- 4.4% for diamine, 96.0 +/- 5.4% for spermidine and 104.1 +/- 3.3% for spermine. Furthermore excellent linearity was demonstrated. Within-run precision of polyamine in blood was excellent, namely, in C.V., 1.15% for Reaction 1, 2.11% for Reaction 2 and 2.79% for Reaction 3. This method was compared with high pressure liquid chromatography (HPLC), and a close correlation was demonstrated for all the fractions: diamine r = 0.8824, y = 1.367x+0.0417 (n = 15); spermidine r = 0.9878, y = 0.806x+5.218 (n = 15); spermine r = 0.9764, y = 1.068x-0.9195 (n = 15).

Chromatography, High Pressure Liquid↗
PubMed1985

Obesity indices and their interrelationships when applied to workers.

Using results of periodic health examinations of middle or small size establishments in Kitakyushu-City conducted by an occupational health service from April to September in 1982, the relationships among ten obesity indices of 30-59 years old male workers (27,376 persons) were investigated classified by age groups (30-39, 40-49 and 50-59 age groups) and by occupations (total occupation, field workers and office workers). Obesity indices adopted here are those derived from weight and height and are used mostly in Japan. Though the means of obesity values were various, the means in the 40-49 age group were higher than those in other age groups through all the indices and all the occupations. And those for office workers were higher than those for field workers through all the indices and all the age groups. The percentage of workers whose obesity values were 20+ in the Minowa index was about 14% and this percentage was attained almost by 20+ in the Katsura and the Kato indices, by 15+ in the NK, the Matsuya, the Matsuki and the CN indices, by 5+ in the Broca index, by 25+ in the Quetelet index and by 156+ in the Rohrer index. Though the percentage of hypertensive office workers was higher than that of hypertensive field workers in the 40-49 age group, proportion adjusted by any obesity index was similar and there were scarcely any differences of adjusted proportions between office workers and field workers.

Adult↗
PubMed1985

Interaction of methionine-specific tRNAs from Escherichia coli with immobilized elongation factor Tu.

The interaction of three different Met-tRNAsMet from E. coli with bacterial elongation factor (EF) Tu X GTP was investigated by affinity chromatography. Met-tRNAfMet which lacks the base pair at the end of the acceptor stem binds only weakly to EF-Tu X GTP, while Met-tRNAmMet has a high affinity for the elongation factor. A modified Met-tRNAfMet which has a C1-G72 base pair binds much more strongly to immobilized EF-Tu X GTP than the native aminoacyl(aa)-tRNA with non-base-paired C1A72 at this position, demonstrating that the base pair including the first nucleotide in the tRNA is one of the essential structural requirements for the aa-tRNA X EF-Tu X GTP ternary complex formation.

Chromatography, Affinity↗
PubMed1985

Modification of the amino acid acceptor stem of E. coli tRNAMetf by ligation of chemically synthesized ribooligonucleotides.

The single-stranded region of the amino acid acceptor stem corresponding to the 3'-end of E. coli tRNAMetf was replaced by ligation of chemically synthesized ribooligonucleotides, in order to change the length of the single-stranded CCA terminus. The chemically synthesized ribooligomers, CCA, ACCA, AACCA and CAACCA, were ligated to nuclease-treated E. coli tRNAMetf, which lacked the ACCA sequence at the 3'-end. The methionine acceptor activities of these modified tRNAs were examined using E. coli methionyl-tRNA synthetase. Ligation of the chemically synthesized pentamer (AACCA) to the acceptor terminus restored the methionine acceptor activity, whereas ligation of the hexamer (CAACCA) or trimer (CCA) to the acceptor terminus did not Modification of the acceptor terminus had no effect on the formylation of accepted methionine.

Amino Acids↗