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T Deutsch

Publications and source records attributed to T Deutsch.

40 records · Page 3Linked to original sources

Application of computers in diabetes care--a review. I. Computers for data collection and interpretation.

The paper reviews the contribution of information technology (IT) to diabetes care. An appraisal of this topic with respect to insulin-dependent (type 1) diabetic patients is carried out in view of the landmark findings of the Diabetes Control and Complications Trial (DCCT) which has demonstrated that maintaining tight blood glucose control can delay the onset and slow the progression of the later life complications of diabetes. The review starts with the clinical background and the main features of the control schema in which diabetic patients receive insulin therapy. An overview is then provided of recent IT initiatives in diabetes care, and the application of IT techniques to assist in the diagnosis and characterization of patients with diabetes mellitus is considered. The role of IT approaches for short-term glycaemic control is discussed and the utilization of computers for collecting, viewing and interpreting home monitoring blood glucose data is reviewed; both quantitative and qualitative techniques being considered. In the second paper the role of decision support tools for planning insulin therapy using clinical algorithms, hand-held devices, knowledge-based approaches, telemedicine techniques and interactive simulations is reviewed, and the validation and clinical evaluation of these tools is discussed. The likely impact of the routine clinical application of implantable/non-invasive blood glucose monitoring devices is also considered. Finally, the application of computers as teaching tools is reviewed and the ways in which such educational approaches might be applied for disseminating the benefits of the DCCT trial more widely are discussed.

Blood Glucose Self-Monitoring↗

Application of computers in diabetes care--a review. II. Computers for decision support and education.

This paper concludes a review of the contribution of information technology to diabetes care. The role of decision support tools for planning insulin therapy using various clinical algorithms, knowledge-based approaches and interactive simulations is discussed, and certain telemedicine approaches to therapy are considered. The validation and clinical evaluation of these tools is reviewed, as is the likely impact of the routine clinical application of implantable/non-invasive blood glucose monitoring devices. Finally, the application of computers as teaching tools is considered, and ways in which such educational approaches might be applied for disseminating the benefits of the Diabetes Control and Complications Trial more widely are discussed.

Artificial Intelligence↗

UTOPIA: a consultation system for visit-by-visit diabetes management.

UTOPIA (UTilities for OPtimizing Insulin Adjustment) is a prototype computer system proposed to support home data analysis and therapy recommendations for the individual patient. The paper describes methods of analysis and their incorporation into an overall system design that matches the iterative practices at the physician-patient consultation from visit to visit. Four modules support home data display and comparison with clinical measurements; extraction of blood glucose trends and daily cycles using time series analysis, learning relationships between insulin adjustments and changes in time series patterns via a parametric, linear systems model; and advice generation by solving the linear equation for candidate insulin adjustments. Concepts and methods are placed in context, with a discussion of comparable and related research.

Algorithms↗

Properties of the melanin binding of p-bromo-methylamphetamine (V-111).

The aim of the present study was to obtain detailed information on the binding properties of p-bromomethylamphetamine (V-111) to melanins under in vitro and in vivo conditions. The results obtained by the methods of both equilibrium and dynamic dialysis revealed that the binding of V-111 to bovine eye melanin was reversible, at least for the part of the binding sites, whereas the dissociation of V-111-melanin adduct was slow. The binding capacity of two different classes of binding sites of bovine eye melanin and dissociation constants of the drug-melanin complexes have been determined. The in vivo melanin binding of V-111-1-14C was studied by the method of whole body autoradiography. Extensive accumulation and retention was observed in the eyes of the pigmented mice while in the albino animal uptake was low in the corresponding tissues. In conclusion, V-111 may most probably be accumulated and retained for long periods in the pigmented cells of intact animals. Our data also imply that melanin in the pigmented cells serves as a depot, which gradually releases p-bromo-methylamphetamine resulting in a prolonged local effect of this compound.

Animals↗