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Biomedical subjects

T Datta

Publications and source records attributed to T Datta.

At least 19 recordsLinked to original sources
PubMed2000

Clinical spectrum of Glanzmann's thrombasthenia.

Glanzmann's thrombasthenia is a well defined inherited disorder of platelet function characterized by qualitative and qualitative defect in cytoadhesive membrane protein, glycoprotein IIb-IIIa (the platelet fibrinogen receptor). From January 1990 to October, 1999, five patients who presented with mucocutaneous bleeding were detected to have Glanzmann's thrombasthenia. Clinical and laboratory spectrum of this rare disorder was studied which revealed heterogeneity of disease with respect to nature and severity of bleeding unpredictable by laboratory findings.

Adolescent↗
PubMed1997

Longitudinal study of human milk creamatocrit and weight gain in exclusively breastfed infants.

OBJECTIVE: To determine the creamatocrit values of breastmilk at different lactational periods during the first 6 months after delivery and its relation to infant growth. DESIGN: Prospective follow-up study. SETTING: Maternity and well baby clinics of a metropolitan teaching, a rural teaching and a suburban municipal hospital. SUBJECTS: 1322 exclusively breastfed infants and their mothers. There were 160 preterm, 281 term low birth weight (LBW) and 881 term appropriate for date (AFD) babies. METHODS: Creamatocrit of breastmilk and infant's body weight were recorded at 4,8,12,16,20 and 24 weeks after birth. RESULTS: Creamatocrit values of breastmilk in all mothers increased upto 16 post partum weeks and then declined. There were no significant differences in creamatocrit values of breastmilk of mothers of preterm, term LBW and term non-LBW infants. Preterm and term LBW infants showed a catch up in body weight with the term AFD group by 20 weeks post-partum. CONCLUSIONS: The breastmilk creamatocrit progressively rises upto the fourth month of lactation but is not influenced by gestation or intra uterine growth retardation. There is no relationship between breastmilk creamatocrit and infant growth. Exclusive breast feeding adequately supports growth of LBW infants in comparison to their normal peers during the first 6 months of life.

Body Weight↗
PubMed1991

Chromosome analyses in chronic lymphocytic leukemia and related B-cell neoplasms.

Chromosome analyses were performed by routine G-banding in 29 patients with B-cell chronic lymphocytic leukemia (B-CLL), six with immunocytoma (IC), three with centroblastic-centrocytic (cb-cc) lymphoma, and one with hairy cell leukemia (HCL). Ages of the patients were between 46 and 81 years (mean, 63 years). 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was used as a mitogen to stimulate leukemic B-cells in 72-hour cultures. Twenty-one patients had one or more chromosomal abnormalities; and in 13 patients, they were clonal; 18 patients had a normal karyotype. Seven patients had trisomy 12 (three B-CLL, two IC, two cb-cc lymphoma); two (B-CLL) had it as the sole abnormality. One patient with B-CLL had trisomy 18 as the sole abnormality, and one with IC had trisomy 18 in combination with trisomy 19. One patient with B-CLL had t(1;6)(p36;p21) as a clonal structural abnormality. A t(11;14)(q13;q32) was consistently observed in one patient with cb-cc lymphoma together with inv(1) (p22p36), der(4)t(4;?)(p16;?), del(6)(q13) and other variable changes. One patient with morphologically atypical B-CLL had t(1;11)(p36;q13) together with der(X)t(X;?)(q26;?), der(3)t(3;?)(q29;?), der(8)t(4;8)(q12;q24.1) and additional variable changes. Both patients with these complex karyotypes were in an advanced stage of disease (Binet stage C) and died within 3-6 months after chromosome analysis.

Aged↗