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Biomedical subjects

T D Seth

Publications and source records attributed to T D Seth.

33 records · Page 2Linked to original sources
PubMed1980

Effect of extent of myocardial damage on the behavior of myocardial zinc in albino rats.

The effect of the extent of myocardial necrosis on myocardial zinc was studied in albino rats. Varying degrees of myocardial necrosis were produced by subcutaneous injection of two different doses of isoproterenol (85 mg/kg body wt and 42.5 mg/kg body wt). Myocardial necrosis was confirmed by serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum lactate dehydrogenase (SLDH), ECG, and histology. Myocardial zinc was depleted after the administration of isoproterenol. This depletion was proportional to the extent of myocardial damage. There was an attempt by the heart for re-uptake of zinc. However, this re-uptake could not be sustained in hearts with more extensive cardiac damage.

Alanine Transaminase↗
PubMed1979

A temporal profile of changes in myocardial manganese after isoprenaline induced cardiac necrosis in albino rats.

Myocardial-necrosis was produced in two groups of albino rats by subcutaneous injection of isoprenaline in doses of 85 mg/kg and 42.5 mg/kg. The necrosis was confirmed by ECG changes, increased serum activities of AspAT, AlAT, GPT and LDH, and by histological examination. Myocardial manganese after isoprenaline administration was estimated over a period of 5 days. The decrease in myocardial manganese was proportional to the extent of cardiac damage. The possible mechanisms and the importance of these changes are discussed.

Animals↗
PubMed1978

Dopamine and noradrenaline levels in the brains of lead and zinc poisoned rats.

Acute plumbism include recurrent seizures, cerebral palsy and mental retardations. The impairment of the central nervous system (CNS) with increased lead absorption is of paramount concern which remains unsolved because of the lack of specific and sensitive neurochemical/biochemical indicators of the effect of lead on the CNS. In our experimental acute lead-zinc poisoning, significant increase in noradrenaline and slight decrease in dopamine have been found in the brains of rats, which suggest that there is change in neurotransmitter metabolism in lead poisoning.

Animals↗
PubMed1978

A temporal profile of myocardial zinc changes after isoproterenol induced cardiac necrosis.

Changes in myocardial zinc level was followed up over a period of 5 days after producing myocardial necrosis in albino rats by subcutaneous injection of isoproterenol, 85 mg/kg body weight. Myocardial necrosis was confirmed by ECG (Lead II), histology and serum enzyme studies (SGOT, SGPT and LDH). A decrease in myocardial zinc level was observed on all the five days. The possible mechanism and the therapeutic implications of these changes are discussed.

Alanine Transaminase↗
PubMed1978

A temporal profile of changes in myocardial copper after isoproterenol induced cardiac necrosis.

The changes in myocardial copper were studied over a period of five days after producing myocardial necrosis in albino rats by subcutaneous injection of isoproterenol. Two different doses of isoproterenol (85 mg/kg & 42.5 mg/kg) were used to study the effect of variation in the extent of myocardial damage on the behaviour of myocardial copper. It was interesting to note that there was mainly an increase in myocardial copper with the lower dose of isoproterenol whereas there was mainly a fall in myocardial copper with the higher dose of isoproterenol. It has been hypothesized that this difference in behaviour of myocardial copper with respect to the different doses of isoproterenol is related to the extent of the myocardial tissue which escapes injury. Confirmation of myocardial necrosis was done by ECG, enzymes (SGOT, SGPT & LDH) and histology. Estimation of myocardial copper was done by atomic absorption spectrophotometry (Perkin Elmer 303).

Alanine Transaminase↗
PubMed1976

The effect of lead and cadmium on liver, kidney, and brain levels of cadmium, copper, lead, manganese, and zinc, and on erythrocyte ALA-D activity in mice.

Lead and cadmium were administered intraperitoneally, singly and jointly, to the mice. The levels of cadmium, copper, manganese, lead and zinc were determined in liver, kidney and brain by atomic absorption spectrophotometric technique and delta-aminolevulinic acid dehydratase (ALA-D) activity was determined in erythrocytes. The tissue levels of some of these metals were found significantly altered by cadmium and lead both, but cadmium was found to have no effect on blood on ALA-D activity.

Animals↗
PubMedDate not supplied

Organochlorine pesticides in specimens from women undergoing spontaneous abortion, premature of full-term delivery.

Organochlorine insecticides (BHC, aldrin, p,p'-DDE, p,p'-DDD, p,p'-DDT) were measured in the blood, placenta and fetus of women experiencing spontaneous abortions, preterm labor or full-term labor using an electron-capture gas chromatographic method. The following trend was found for insecticide concentrations in each of the specimens tested: spontaneous abortions greater than preterm greater than full-term. One conclusion of this work is that the organochlorine insecticides act as antagonists to pregnancy. A plausible explanation for the facilitory role of organochlorine insecticides in the initiation of preterm labor/abortion is hypothesized.

Abortion, Spontaneous↗
PubMedDate not supplied

Organochlorine pesticide residues in different Indian cereals, pulses, spices, vegetables, fruits, milk, butter, Deshi ghee, and edible oils.

A total of 244 samples of cereals (wheat flour, rice, and maize), pulses (arhar, moong, gram, lentil, and black gram), spices (turmeric, chili, coriander, and black pepper), vegetables (potato, onion, spinach, cabbage, brinjal, and tomato), fruits (mango, guava, apple, and grape), milk, butter, Deshi ghee, and edible oils (vegetable, mustard, groundnut, and sesame) collected from different cities of Northern Province (Utter Pradesh) were analyzed by gas liquid chromatography for the presence of organochlorine pesticide residues. Residues of hexachlorocyclohexane (HCH) and 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) were detected in about 85% of the total samples of cereals, spices, milk, butter, Deshi ghee, and edible oils analyzed in the present study. However, the residue levels were either very small (less than 0.06 ppm) or not detected at all in pulses, vegetables, and fruits as compared with very high concentrations in wheat flour (4.42 and 0.12 ppm), butter (1.19 and 4.85 ppm), mustard oil (1.26 and 2.42 ppm), Deshi ghee (1.10 and 3.84 ppm), vegetable oil (1.02 and 0.59 ppm), groundnut oil (0.51 and 1.49 ppm), and chili (0.48 and 1.92 ppm). The levels of HCH and DDT residues detected in rice, maize, turmeric, corlander, black pepper, and all the vegetables and fruits were also lower than those found in wheat flour, oil, and fat samples analyzed in the present study. These findings suggest that a restricted and controlled use of such persistent pesticides may be useful for decreasing their contamination levels in different food items.

Animals↗