The relationship of plasma amylase to pancreatic damage induced by ethionine.
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Biomedical subjects
Publications and source records attributed to T D KINNEY.
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Groups of rats were fed a diet of the purified type which was supplemented by dl-ethionine to produce pancreatic damage. It was shown that animals with pancreatic damage absorbed more iron from the gastrointestinal tract than control animals without pancreatic damage. When iron was added to the diet the animals with pancreatic damage absorbed even greater quantities of iron. These findings in rats were corroborated by similar findings in mice.
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The response of rats, chicks, mice, and guinea pigs to two diets containing various amounts of iron has been compared. With diets composed chiefly of corn grits animals of all these species absorb and store considerably more iron than those with normal diets of the same iron content. If sufficient iron is added to a normal diet, all species will absorb large amounts of iron. However, there appear to be great species differences in the level of iron which must be fed to cause the increase in absorption. Chicks and mice appear to have less effective control over iron absorption on high iron diets. Attention is called to large individual differences in ability to control iron absorption under the conditions of these experiments.
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