Biomedical subjects
Publications and source records attributed to T D Healing.
Etomidate, a new nonbarbiturate short-acting hypnotic agent, was effective in anaesthetizing laboratory mice at a dose of 23.7 +/- 1.5 mg/kg bodyweight ip. Surgical anaesthesia developed which permitted the performance of operations upon the animals for at least 20 minutes after induction. In these mice (LACA-2 and C57-BL strains), doses up to 33 mg/kg were tolerated. Recovery from anaesthesia was uncomplicated.
Four populations of small wild British rodents were studied by capture--re-capture methods over a period of three years. Samples of blood were taken from these animals and tested for antibodies to nine viruses. Animals were removed from another 11 sites around the UK, and immunosuppressed. Samples of tissue from these animals were tested for the presence of viruses by passage in laboratory mice and serum samples from some of them were tested for antibody to the nine viruses. Indications were found of the possible influence of epizootic outbreaks of certain diseases on animal populations.
Over a four-year period 878 samples of faeces were collected from five species of small wild rodents and two species of shrews at sites in England, Scotland and Wales. A search was made for Salmonella in these samples but no isolations of this genus were made. Several other genera of Enterobacteriaceae were identified.
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