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Biomedical subjects

T Cooke

Publications and source records attributed to T Cooke.

77 records · Page 5Linked to original sources
PubMed1979

Oestrogen receptors and prognosis in early breast cancer.

In a study of the role of oestrogen-receptor analysis in early breast cancer the oestrogen-receptor content of the tumour was estimated in 286 patients undergoing mastectomy. These patients were followed for up to 39 months, and the recurrence of disease was noted in relation to the presence or absence of oestrogen receptor.Recurrence-rates were significantly higher in patients whose tumours did not contain receptors than in those whose tumours did. This same relationship was seen when women with and without axillary metastases were considered separately. The highest rates of recurrence were in women with axillary lymph-node involvement whose tumours lacked oestrogen receptors. Women without axillary-node involvement whose tumours lacked oestrogen receptors showed the same high rate of recurrence as all women with axillary-node involvement. The oestrogen-receptor content of a primary breast cancer appears to be an independent guide to early recurrence of the disease.

Breast Neoplasms↗
PubMed1978

A microsurgical technique for the creation of arteriovenous fistulas.

A new method for creating arteriovenous fistulas employing microvascular techniques is described. It is proposed that this method should be used in problem cases where conventional means have failed or as a first procedure in cases in which technical problems are envisaged. A two-stage microvascular procedure has been used to create adequate fistulas in these difficult cases. Satisfactory fistulas have been formed in 15 out of 16 patients in whom these techniques have been used.

Adolescent↗
PubMedDate not supplied

Cholesterol and lipoprotein (a) levels in psoriasis.

Psoriasis is a common condition in the western world, but is uncommon in populations with a low prevalence of atherosclerosis such as Japanese, Blacks and indigenous North Americans. Psoriasis appeared to be more prevalent amongst patients attending our lipid clinic compared to the general population. Lipoprotein (a) (Lp(a)) is elevated in conditions such as coronary heart disease and protein loosing nephropathies. Psoriasis is a condition of increased epidermal protein turnover and loss and thus it might be postulated that increased levels of Lp(a) may be found in patients with psoriasis. The aim of this study was to explore an association between psoriasis and Lp(a) and lipid profiles. No association was found between Lp(a) concentrations and psoriasis. Although six of 36 patients were found to have a cholesterol greater than 7.5 mmol L-1, the mean cholesterol for this group was not elevated.

Adult↗