The familial nature of scrotal and geographic tongue was investigated in parents and siblings of 156 probands having these conditions. The prevalence in parents and siblings was significantly higher than that in the control populations. The prevalence in sibilings from families in which at least one parent was also affected was significantly higher than that in siblings from families in which neither parent was affected. The prevalence of scrotal tongue alone in siblins was similar irrespective of the condition in the proband. The prevalence of geographic tongue alone was highest in siblins of probands having only geographic tongue. A polygenic mode of inheritance with some genes common to both conditions is suggested.

Adolescent↗

PubMed1976

Leg ulcers in a family with both beta thalassaemia and glucose-6-phosphate dehydrogenase deficiency.

A family is presented in which the proposita, affected with thalassaemia major, developed a chronic leg ulcer at the age of 14 years. Her eldest brother, not affected with thalassaemia, had a transient leg ulcer at the age of 18 years and a second brother, affected with thalassaemia minor, developed leg ulcers when aged 15 years. Al three siblings were glucose-6-phosphate dehydrogenase deficient.

Adolescent↗

PubMed1976

The karaite community of Iraq in Israel: a genetic study.

Ninety-eight of 136 (72%) individuals at least 6 years of age from a small isolate of the Karaite community, known to have lived in Iraq since the tenth century, were examined. In Iraq this group maintained a highly inbred existence but married Karaites from Egypt after their immigration to Israel in 1951. Observations of several unique gene frequencies for blood group and isoenzyme markers, not described among other Jewish groups, are explicable by isolation and genetic drift in a very small community.

ABO Blood-Group System↗

PubMed1975

Letter: Alpha-fetoprotein during mid-trimester induced abortion.

Explore the source record for details and available documents.

Abortion, Induced↗

PubMed1975

Familial scoliosis. A clinical report.

Scoliosis appeared in fifteen members of a family in three generations. The eight members examined showed an idiopathic type of scoliosis. Father-to-son transmission occurred more than once. Although at first appearance transmission of the scoliosis is as an autosomal dominant trait, the concept of polygenic inheritance, as has been shown in previous population studies, could also explain the inheritance in this family.

Adolescent↗

PubMed1974