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Biomedical subjects

T Chiba

Publications and source records attributed to T Chiba.

At least 721 records · Page 40Linked to original sources
PubMed1975

The synaptic structure of catecholaminergic axon varicosities in the dorso-medial portion of the nucleus tractus solitarius of the cat: possible roles in the regulation of cardiovascular reflexes.

The study was performed on adult mongrel cats to investigate synaptic structures of nerve terminals in the dorso-medial portion of the nucleus tractus solitarius (NTS), where majorities of the cardiovascular afferent fibers terminate and a dense plexus of the catecholaminergic nerves exists. In normal control groups, axo-dendritic and axo-somatic contacts were commonly observed but no axo-axonic contacts were seen. Synaptic vesicles were almost exclusively spherical (97%) and less frequently flat (3%). Small cored vesicles were not observed in animals with formalin-glutaraldehyde and osmium tetroxide fixation. Two or three days after denervation of IXth and Xth cranial nerves, degenerated axon varicosities occupied about 15-20% of total population. Quantitative analysis after intracisternal injection of 5-hydroxydopamine revealed 3 different types of the varicosity: varicosities with spherical clear vesicles (85%), flat clear vesicles (3%) and small cored vesicles (12%). Axon varicosities with small cored vesicles predominantly exhibited axo-dendritic synapses and occasionally showed the closed apposition with those containing spherical clear vesicles. 6-Hydroxydopamine produced a minimal degree of degenerative changes in some axon varicosities (less than 5%). Treatment with 5-hydroxydopamine after IXth and Xth cranial nerve section gave intact axon varicosities with small cored vesicles. In conclusion, there is a relatively dense innervation of catecholaminergic nerves in the dorso-medial portion of the NTS, which apparently does not stem from the IXth and Xth cranial nerves. Possible roles of catecholaminergic nerves are discussed.

Animals↗
PubMed1975

Differentiation of biliary atresia from neonatal hepatitis by routine clinical examinations.

After analysis of 33 cases of neonatal hepatitis and 90 cases of biliary atresia, a score test from history, physical findings and daily laboratory examinations was studied for the differential diagnosis of these two diseases. The biliary atresia takes plus score, whereas the neonatal hepatitis takes minus score. The score test is of great value for the differential diagnosis between these two diseases.

Alkaline Phosphatase↗
PubMed1975

An attempt to determine surgical indication for biliary atresia by laboratory examination.

To determine the surgical indication of biliary atresia, we analyzed the history, physical findings and laboratory examinations of 90 cases of biliary atresia operated upon at the Second Department of Surgery, Tohoku University Hospital during the past 10 years, from 1963 through 1972 inclusive. A score table from the data of these examinations was made for the determination of surgical indication. According to this score table, all of the patients who showed good excretion of bile took plus score, whereas a half of the patients who showed poor or no excretion of bile took minus score. Although the remaining patients who showed poor excretion of bile took plus score, these cases had some elements for good excretion of bile. From these results, the patients who takes plus score is considered to be a good indication for operation. The score test is of great value for determination of the surgical indication of biliary atresia.

Age Factors↗
PubMed1975

Reconstruction of intrahepatic bile ducts in congenital biliary atresia.

Macroserial reconstruction of the main intralobular bile ducts was made in 7 cases of biliary atresia; 2 cases of type I, 1 case of type II and 4 cases of type III according to Kasai's classification. From the results of these reconstruction studies, it was confirmed that the main interlobular bile ducts are usually patent through the liver regardless of the type of atresia of the extrahepatic bile ducts. A microserial reconstruction of bile ducts and ductules of a small portal tract performed in one case disclosed that a number of ductules make a network around the main duct and have some communications with the main duct. These results were compatible with the fact that active excretion of bile was obtained in many postoperative patients with biliary atresia. As observed in one case of the present series, postoperative complication of severe ascending cholangitis seemed to be an important cause of destruction or disappearance of intrahepatic bile ducts, which has also seen in older infants with this disease without complicaion of cholangitis. In view of these facts the operation of an early stage of life is recommended in biliary atresia.

Autopsy↗