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Biomedical subjects

T Carr

Publications and source records attributed to T Carr.

53 records · Page 3Linked to original sources
PubMed1986

Study of childhood renal tumours using antisera to fibronectin, laminin, and epithelial membrane antigen.

Using a peroxidase-antiperoxidase staining procedure, formalin fixed paraffin embedded sections of fetal and normal kidney; benign (mesoblastic nephroma); and malignant tumours (Wilms' tumour, clear cell renal carcinoma, rhabdoid renal tumour, and bone metastasising renal tumour of childhood (BMRTC] were examined for their reactivity with antisera to fibronectin, laminin, and epithelial membrane antigen. Mesoblastic nephroma contained fibronectin but no laminin. Most Wilms' tumours lacked both fibronectin and laminin; 50% of rhabdoid renal tumours were positive for fibronectin and laminin--rhabdoid tumours as recognised morphologically may, in fact, be two separate entities. BMRTC and clear cell renal carcinoma lacked both fibronectin and laminin. Epithelial membrane antigen was present in most of the tubular Wilms' tumour but absent in blastemal Wilms' tumours. The presence of epithelial membrane antigen in rhabdoid tumours was surprising, as histologically, this type of tumour shows no sign of epithelial differentiation. Epithelial membrane antigen antiserum stained clear cell renal carcinomas: epithelial membrane antigen is found in the distal and not the proximal tubules of fetal and normal kidneys. Thus an obvious interpretation is that clear cell renal carcinomas originate from distal rather than from proximal tubules, as has always been thought. On the basis of these results and data from other published findings some possible histogenetic origins of childhood renal tumours were proposed.

Adenocarcinoma↗
PubMed1986

Study of childhood renal tumours using peroxidase conjugated lectins.

Six peroxidase conjugated lectins were used to compare their ability to bind to formalin fixed paraffin embedded tissue sections of childhood renal tumours (Wilms' tumour, mesoblastic nephroma, renal carcinoma, rhabdoid renal tumour, and bone metastasising renal tumour of childhood (BMRTC) with fetal and normal children's kidney. Lectins were found to be helpful in the differential diagnosis of renal tumours. Another important finding was that the mesenchyme of renal tumours showed differences in its reactivity among various types of kidney tumours. The results of lectin binding were not helpful in establishing the origin of kidney tumours.

Child↗
PubMed1986

An unusual presentation of non-Hodgkin's lymphoma (NHL) in a child.

A rare case of a primary early T-cell non-Hodgkin's lymphoma (NHL) in the bronchus of a 10 year old boy is presented. Although histological examination of the biopsied material was compatible with the diagnosis of NHL or carcinoma, the use of monoclonal antibodies showed it to be an early T-cell NHL and not carcinoma. Accordingly the child was treated using a chemotherapy protocol of the UKCCG for NHL. The patient responded so well to his treatment regime that within 2 weeks of the initiation of chemotherapy there was re-expansion of the collapsed lobe. Six weeks later bronchoscopy was entirely normal with no evidence of residual tumour and now 15 months after the time of diagnosis he remains very well with normal chest X-ray.

Antibodies, Monoclonal↗
PubMed1986

Screening for antenatal and postnatal depressive symptoms in general practice using a microcomputer-delivered questionnaire.

One-hundred and eight women participated in a study which screened for depressive symptoms in the antenatal period. Of these women, 92 completed at least two further screenings during the postnatal year. The screening tool was the Hamilton Depression Rating Scale, adapted for self-rating, and administered by a microcomputer. It was found that mean scores and the prevalence of depressive symptoms rose throughout pregnancy, with a sharp peak in the third trimester. Following delivery there was an abrupt fall in the prevalence of depressive symptoms, followed by another rise, with a postnatal peak at six months.There were significant associations, at all levels of severity, between raised scores antenatally, and those developing postnatally in women completing the study. These were more marked in multiparae than primiparae. There was also a significant association between a past history of treated depression and the development of raised postnatal scores for depression.The routine use of a microcomputer to administer questionnaires to patients has proved feasible within general practice.

Depression↗
PubMed1985

Mesoblastic nephroma contains fibronectin but lacks laminin.

Non-metastatic mesoblastic nephromas from four young children were shown to contain fibronectin but not laminin using an immunoperoxidase staining procedure. In contrast, one metastasising spindle celled sarcomatous tumour from a neonate was laminin positive. During embryogenesis primitive nephrogenic mesenchyme contains only fibronectin and no laminin; metanephric blastema (permanent kidney) is positive for laminin. The staining for fibronectin and laminin may help to ascertain the histogenesis of different types of renal tumour.

Female↗
PubMed1984

A trial of faith.

Explore the source record for details and available documents.

Angina Pectoris↗
PubMed1984

A scoring system for Wilms' tumour: pathological study of the second Medical Research Council (MRC) trial.

The second MRC nephroblastoma trial was devised to determine whether more intensive chemotherapy in the early stages and multiple chemotherapy in the poorer prognosis groups would give improved results. As a separate study the pathological and clinical aspects were assessed to see whether information may be obtained concerning the behaviour of individual tumours of the 159 cases included, 142 were regarded as nephroblastoma. Significant features were the age of the patient, clinical stage at diagnosis, tubular status of the neoplasm and the presence or absence of anaplasia. A scoring system has been devised to take account of these factors.

Adolescent↗
PubMed1983

Human lung tumour cell line adapted to grow in serum-free medium secretes angiogenesis factor.

A human lung tumour cell line has been grown in serum-free medium for 12 months and during this period cells were subcultured every 4 days. The culture medium contained an angiogenesis factor which has been purified and shown to be similar to that isolated from other sources including solid tumours. This is the first report that demonstrates de novo synthesis and secretion of angiogenesis factor by a cell line adapted to grow in a serum-free medium.

Angiogenesis Inducing Agents↗
PubMed1983

Angiogenesis factor from human myocardial infarcts.

5 of 8 infarcted human myocardial tissues were shown to contain an angiogenesis factor which resembles that obtained from solid tumours. The concentration of angiogenesis factor, measured by radioimmunoassay, was similar to that in tumours. It is suggested that the myocardial-infarct angiogenesis factor modulates collateral enlargement or ingrowth of new blood vessels in the infarcted tissues.

Aged↗
PubMedDate not supplied

Nuclear magnetic resonance imaging, a new approach to the investigation of refractory temporal lobe epilepsy.

Nuclear magnetic resonance is a noninvasive technique of imaging the brain using signals produced by magnetic fields and radiowaves. Sixteen patients with refractory temporal lobe epilepsy (TLE) had magnetic resonance imaging (MRI) during investigation for possible surgical management. These images plus those of 10 normal controls, were interpreted blind and the results from the TLE patients compared to the EEG and computerized tomographic (CT) scan findings. Fourteen patients compared with one normal control had one or more of the following: small temporal lobe, small mesial temporal structures, small hemisphere, and focal mesial temporal prolonged spin-spin relaxation time. These findings correlated with the electrographically determined seizure focus in 11 patients. Enlarged or asymmetrical temporal horns were seen with equal frequency in patients and controls and did not correlate with the seizure focus. CT scans were less likely to show these changes than MRI. Correlation of the MRI changes with histopathology of resected temporal lobes was poor. MRI reveals structural and possibly functional alterations which may aid in the localization of the seizure focus in the temporal lobes of patients with refractory complex partial seizures.

Adolescent↗