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T C Wei

Publications and source records attributed to T C Wei.

At least 55 records · Page 3Linked to original sources
PubMed1987

Small hepatocellular carcinoma: intratumor ethanol treatment using new needle and guidance systems.

Intratumor injection of absolute ethanol to treat small hepatocellular carcinoma sometimes results in incomplete necrosis of the tumor. Causes of this include inhomogeneous distribution of the ethanol and difficulty in identifying the tumor after previous ethanol injections. To solve these problems, the authors designed a multiple-side-hole needle for ethanol injection and implanted one or more small steel coils into the tumor before treatment to serve as a landmark. Six patients thus treated all showed adequate necrosis on follow-up computed tomography, biopsy, and angiography studies; initially elevated serum alpha-fetoprotein levels present in five patients were decreased. A resected surgical specimen obtained in one patient showed extensive necrosis of the tumor as well as of the surrounding healthy liver; only a small locus of equivocally viable cancer cells remained in the tumor margin.

Aged↗
PubMed1987

Intratumor injection of absolute ethanol under ultrasound guidance for the treatment of small hepatocellular carcinoma.

For the treatment of small hepatocellular carcinoma, intratumor injection of absolute ethanol under ultrasound guidance was performed in 27 tumors in 23 patients, with a tumor diameter of between 1.0 and 3.3 cm. The initially elevated serum alpha-fetoprotein levels in 15 patients decreased during treatment, with 13 returning to normal after this regimen. In the 6 patients who finally received surgical resection, 4 had complete necrosis of the tumor, while the other 2 had a small peripheral residual cancer nest. In the remaining non-resected 17 cases, follow-up CT, multiple biopsies and angiography revealed evidence of viable tumor in only 3 cases. After additional ethanol injections, these 3 cases were successfully treated. Inhomogeneous distribution of the injected ethanol and difficulty in identifying the tumor after previous injections accounted for the incomplete necrosis of the tumor. To cope with these problems, a steel coil was implanted in the tumor before treatment, and a needle with multiple side holes was used in the last 3 cases, with satisfactory results. Ethanol injection is promising and may even be curative in the treatment of small hepatocellular carcinoma.

Adult↗
PubMed1986

Histologic assessment of resected hepatocellular carcinoma after transcatheter hepatic arterial embolization.

Ten cases of large hepatocellular carcinoma (HCC) (largest diameter, 6.5-15 cm) were surgically resected from 3 to 19 days after transcatheter hepatic arterial embolization (TAE) for histologic assessment of the effectiveness. Another two patients, including one with a small HCC (3.5 X 3 X 3 cm) who died of complications, were also studied. The patients' ages ranged from 20 to 64 years, 11 were men and 1 was a woman, and all positive for serum hepatitis B surface antigen. All 11 cases with large HCC were symptomatic before the HCC was clinically diagnosed. Alpha-fetoprotein levels were elevated in ten cases but immediately dropped to normal levels after TAE and resection in eight cases. An effective massive tumor coagulative necrosis of 99% already occurred 3 days after TAE. A necrosis involving more than 95% of the whole tumor mass was demonstrated in eight cases: one was a large HCC taken from an autopsy specimen, and TAE was done three times. This strongly indicates the effectiveness of TAE on the destruction of HCC. However, the presence of viable residual tumors in 11 cases also strongly argues for the necessity for surgical resection whenever it is possible. The failure of a complete necrosis was related to the extracapsular extension, liver invasion, satellite nodules, and portal vein involvement, and probably related to collateral and portal vein blood supply.

Adult↗
PubMed1985

Percutaneous transsplenic balloon dilatation for stenotic distal splenorenal shunt.

A 27 year old cirrhotic male underwent stenosis of the distal splenorenal shunt to treat bleeding of esophageal varices. Percutaneous transluminal angioplasty was performed first by catheterization of the right femoral vein, but without success. Therefore, a direct puncture of the splenic vein through the spleen was made, under sonographic guidance, followed by balloon dilatation of the stenotic anastomosis. The pressure of the splenic vein before and after PTA was 35 and 29 cm H2O, respectively. Both the follow-up barium esophagogram and esophagoscopy showed marked regression of the esophageal varices.

Adult↗
PubMed1985

Effect of severe injury and critical illness on high-energy phosphates in human liver and muscle.

Changes in hepatic and muscle high-energy phosphates in varying degrees of resting hypermetabolism were studied. Fourteen severely injured and five critically ill patients with normal blood pressure were investigated: the results were compared with 14 normal controls. ATP and ADP levels in the muscle were significantly changed in acutely severe injury: lactate and pyruvate levels in the liver and muscle increased; glycogen level in the liver decreased. Meanwhile, high-energy phosphates in both liver and muscle were not significantly changed in ongoing severe injury. Lactate level increased and glycogen level decreased in both tissues. In critical illness, hepatic and muscle ATP and ADP decreased significantly. The energy charge potential dropped. AMP, lactate, and the lactate-to-pyruvate ratio increased. Hepatic, but not muscle, glycogen dropped markedly. The correlation coefficient between hepatic and muscle ATP was 0.61; between hepatic ATP and hepatic glycogen was 0.60. Alteration in the ATP-ADP-AMP system in the liver and muscle suggests a low-energy charge in acute, severe injury and critical illness. This indicates a decreased capacity for biosynthetic reactions and production of storage compounds. The changes in high-energy phosphate in the liver always paralleled similar changes in muscle.

Adult↗
PubMed1985

Gallstone ileus.

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Adult↗