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Biomedical subjects

T C Spoor

Publications and source records attributed to T C Spoor.

At least 55 records · Page 3Linked to original sources
PubMed1986

Treatment of optic neuritis with megadose corticosteroids.

Difficulty in distinguishing between monosymptomatic optic neuritis due to autoimmune disease or to intrinsic demyelination in young adults prompted a trial administration of megadose corticosteroids in a series of patients. Treatment with 1 g daily of intravenous methylprednisolone (Solu-Medrol) for 2 to 5 days led to the rapid resolution and restoration of visual function in five patients. Two untreated patients suffered irreversible loss of vision. One patient with known autoimmune disease required a higher dose. The author suggests a trial of megadose, intravenous corticosteroids in patients between the ages of 21 and 45 years with optic neuropathies of uncertain or suspected autoimmune etiology after appropriate neuro-ophthalmologic evaluation.

Adrenal Cortex Hormones↗
PubMed1984

Complications of continuous-wear soft contact lenses in a nonreferral population.

Serious corneal complications occurred in an otherwise successful experience with continuous-wear soft contact lenses (SCLs) for aphakic correction. One hundred twenty eyes were fit, and 92% attained visual acuity of 20/40 or better. Severe corneal complications were observed in 13 eyes, including bacterial ulcers (six), apical erosions (three), and severe superficial vascularization (four). Corneal ulcers occurred in nondiabetic as well as diabetic subjects. Continuous-wear SCLs are not innocuous; as for any other drug or device, continuous, long-term medical supervision is necessary to minimize potentially severe complications and visual loss.

Adult↗
PubMed1983

Orbital myositis.

We report five cases of presumed orbital myositis mimicking extraocular muscle motility disturbances and manifesting clinical signs of active inflammation over the involved muscles. Computed tomographic evidence for extraocular muscle enlargement is helpful in confirming the diagnosis. If not present or atypical, another etiology should be sought. All patients responded rapidly and dramatically to systemic corticosteroids. Anterior inflammation may be accompanied by iritis and respond to topical corticosteroids. We believe the diagnosis of orbital myositis may be made on clinical grounds with confirmation by computed tomographic evidence for extraocular muscle enlargement and clinical response to corticosteroids. Biopsy is unnecessary except in atypical cases.

Adolescent↗
PubMed1983

Ocular syphilis. Acute and chronic.

We describe our experience over the past 2 years with the ocular manifestations in 32 patients with acute and chronic syphilis. We urge that syphilis be considered in evaluating those patients with recurrent iritis, chorioretinitis, papillitis, optic atrophy, or abnormal pupillary findings. Specific serologic testing (FTA-ABS) must be obtained. Screening serologies (VDRL) are inadequate. We suggest that patients with evidence for CSF involvement or active ocular disease be treated by continuous intravenous infusion of 24 million units penicillin G daily for 10 days.

Acute Disease↗
PubMed1982

Retinal embolism following percutaneous femoral cerebral angiography.

A 35-year-old female without evidence of atherosclerotic vascular disease underwent percutaneous femoral cerebral angiography. Perifoveal retinal infarction by exogenous arteriolar emboli produced a permanent absolute pericentral scotoma. Strict adherence to meticulous angiographic technique may prevent such an angiographic complication.

Adult↗
PubMed1982

Aspergillosis presenting as a corticosteroid-responsive optic neuropathy.

A case of orbital aspergillosis presenting as a steroid response of optic neuropathy is presented. The invasive and aggressive nature of this infection in the presence of systemic corticosteroids is documented by serial CT scans and necropsy examination. The authors urge inclusion of aspergilloma in the differential diagnosis of a steroid responsive optic neuropathy.

Adrenal Cortex Hormones↗
PubMed1982

Progressive visual loss, diabetes mellitus, and associated abnormalities (DIDMOAD syndrome).

A syndrome including juvenile-onset diabetes mellitus, optic atrophy, diabetes insipidus, and high-frequency sensorineural hearing loss, expressed completely or partially, is being identified with greater frequency. Visual loss may be progressive and accompanied by primary optic atrophy. Concurrent diabetic retinopathy has only rarely been reported. Visual acuity may deteriorate to less than 20/400. The etiology is unknown. However, histopathologic studies indicate that the diabetes insipidus, optic atrophy, and neurosensory hearing loss represent progressive degenerative conditions. Inheritance appears to be autosomal recessive with incomplete penetrance. The syndrome is rare; therefore, a complete neuroophthalmologic and neuroradiologic evaluation is imperative to rule out a mass lesion. This syndrome should be considered in young people with visual loss and optic atrophy of unknown etiology even if they are not known juvenile diabetics.

Adolescent↗
PubMed1981

Progressive visual loss due to glioblastoma: normal neuroroentgenorgraphic studies.

A case of progressive bilateral visual loss of abrupt onset an rapid course is described. Extensive neurorentgenographic evaluation was normal, and the results of exploratory craniotomy were unremarkable, except for a slight ovality of the left optic nerve. A biopsy of the left optic nerve showed a glioblastoma, apparently originating in the anterior optic pathways.

Blindness↗
PubMed1981

Orbital tuberculosis.

A 37-year-old man had epistaxis, headache, intermittent swelling of the periorbital region, proptosis, epiphora, and chronic sinusitis. X-ray films showed marked erosion of the midline facial bones, total opacification of both maxillary sinuses, and clouding of the sphenoid and left ethmoid sinuses. He also had a cutaneous-maxillary sinus fistula and a purulent discharge. A histopathologic examination disclosed areas of acute and chronic inflammation with occasional noncaseating granulomas. Biopsy specimens and postoperative sputum cultures grew Mycobacterium tuberculosis, although the patient had no obvious signs of systemic disease. Because tuberculosis of the orbit is rare in developed countries, it is often overlooked in the diagnosis of granulomatous inflammation of the orbit. This can lead to exacerbation of the disease by corticosteroid treatment.

Adult↗
PubMed1980

Traumatic hyphema. Failure of steroids to alter its course: a double-blind prospective study.

Forty-three patients with traumatic hypema were studied prospectively in a controlled, double-blind study. Twenty-three patients received prednisone and 20 received a lactose placebo. Secondary hemorrhages occurred in 16% of all patients. There was no significant difference in the incidence of secondary hemorrhage between the two groups (P = .85). There is no evidence that prednisone (40 mg/day) decreases the incidence of secondary hemorrhage. There was no significant difference in final visual acuities between the two groups. Patients with initially larger hyphemas do not appear to have worse final visual acuities. Hyphemas without secondary hemorrhage had a uniformly good prognosis. Although final visual acuities were worse in eyes with secondary hemorrhage, associated ocular injuries rather than blood-related complications accounted for the decreased visual acuity.

Adult↗
PubMed1980

Orbital fine needle aspiration biopsy with B-scan guidance.

In three patients we used B-scan ultrasonography to guide the placement of an aspirating needle, which allowed rapid and accurate cytologic diagnosis of retrobulbar orbital neoplasms. This technique spares the patient the greater costs, inconvenience, and morbidity of more invasive procedures.

Aged↗
PubMed1980

Malignant gliomas of the optic nerve pathways.

We compared the clinical course and histopathologic findings in five patients with malignant gliomas originating from the optic nerve pathways with those in previously reported cases to elucidate further the clinical features of this tumor and facilitate future diagnoses. Patients with malignant optic nerve pathway gliomas had unilateral or bilateral visual dysfunction, which was often accompanied by periorbital discomfort in an otherwise asymptomatic adult. Regardless of origin, the clinical course invariably was bilateral blindness rapidly followed by death. Occasionally, the diagnosis was made preoperatively and was confirmed by surgical exploration and biopsy.

Aged↗
PubMed1980

Dysthyroid and myasthenic myopathy of the medial rectus: a clinical pathologic report.

A patient with simultaneous involvement of the right medial rectus by dysthyroid and myasthenic myopathy is presented. These abnormalities were confirmed by a positive Tensilon test, computerized tomography demonstrating an enlarged right medial rectus, and a right medial rectus muscle biopsy demonstrating histopathology typical of both diseases.

Female↗